[ANALYSIS OF THE SIZE OF THE CEPHALOMETRIC VALUES OF THE FACE AND THE ODONTOMETRIC PARAMETERS OF THE JAWS DURING THE PERIOD OF OCCLUSION CHANGE OF THE DENTAL ROWS].

115 respondents aged 7-11 with occlusive pathology were examined anthropometrically and biometrically. The sizes of the craniofacial complex were studied using the parameters of the width and diagonal of the face. The jaw indices of the face were calculated. The mesio-distal, vestibulo-oral and vertical dimensions of the crowns of primary and permanent teeth were measured. The widths and lengths of dental arches during the period of tooth change were determined by the method of Pont and Korkhaus. Diagnosed mesognathic, dolichognathic and brachygnathic face types with normodont, macrodont and microdontic variants of dental arches. Regardless of the type of dental arches, the ratio of the width of the upper dental arch in the molar region to the similar parameters of the lower one was determined and is 1.02±0.05. The results of the study of the length of the anterior part of the dental arches also indicate that the odontometric indicators are commensurate with each other and this correlation is equal to 1.23±0.05. The correlation of the value of the sum of 14 upper teeth to the sum of 14 lower teeth is 1.15±0.05. The data obtained are used to predict the results of orthodontic treatment.

[IMPROVEMENT OF METHODS FOR THE PREVENTION AND HYGIENE OF THE ORAL MUCOSA OF STOMATHOLOGICAL PATIENTS UNDERGOING HIGH DOSAGE CHEMOTHERAPY].

Aim of the study- improving the methods of prevention and hygiene of the oral mucosa of dental patients receiving high-dose toxic chemotherapy. 55 patients aged from 30 to 65 years of oncological profile with a combined dental pathology were taken for clinical observation. Patients were divided into 2 groups according to the applied methods of oral hygiene: in group 1, a standard hygienic technique was used; group 2 additionally used the hygiene and prophylactic agent "CITO-STOP", adapted for patients undergoing high-dose chemotherapy. Measurement and comparison of the amount of methotrexate in the oral fluid in both groups was carried out according to a single scheme. The measurement was carried out by high performance liquid chromatography immediately before the introduction of methotrexate, then after the start of infusion at the following time intervals: 1 hour, 2 hours, 4 hours, 6 hours, 8 hours, 16 hours, 24 hours, 48 hours, respectively. The study of Candidaalbicans on sensitivity to the author's hygiene and prophylactic agent "CITO-STOP" was carried out in both groups. Means "CITO-STOP" has a declaration of conformity of the Eurasian Economic Union and is approved for clinical use and sale on the territory of the Russian Federation (Patent for invention No. 2607931 dated January 11, 2017). Statistical processing of the results was carried out in both groups according to a single technique. In samples of oral fluid in patients using the optional "CITO-STOP" for oral hygiene, the amount of methotrexate is significantly reduced. The effect of the drug on the Candidaalbicans culture leads to damage to the exocular matrix and subsequent lysis of the Candidaalbicans culture. The developed and tested author's remedy "CITO-STOP" is an effective tool for the prevention and oral hygiene of dental cancer patients. This tool has analgesic, epithelizing and antifungal properties. The amount of methotrexate in the oral fluid after the use of high-dose chemotherapy with the use of the hygienic prophylactic "CITO-STOP" has been proven to decrease. "CYTO-STOP" has a pronounced fungicidal activity Patients of the second group who used the "CITO-STOP" foam for additional oral hygiene and the prevention of post-cytostatic stomatitis noted an improvement in the quality of life by reducing the pain symptom, eliminating bleeding of the mucous membrane and halitosis (halitosis).