[Potentialities of medicinal correction of cerebrovascular disturbances in patients with arterial hypertension].

The use of up-to-date diagnostic methods for the examination of 72 patients presenting with grade II-III arterial hypertension and high risk of cardiovascular complications made it possible to estimate the state of brachiocephalic arteries before and after combined antihypertensive therapy that continued during 14 days. The following variables were measured: blood flow rate, peripheral vascular resistance indices at the extra- and intracranial levels, metabolic indices of cerebrovascular responsiveness, and coefficient of variability as an indicator of the cerebrovascular reserve capacity under conditions of antihypertensive treatment. Three antihypertensive therapeutic regimens were employed, viz. lisinopril plus indapamide, bisoprolol plus indapamide, and amlodipine plus indapamide. It was shown that all the three regimen resulted in positive changes in the parameters of blood flow and peripheral vascular resistance. At the same time, the use of amlodipine plus indapamide ensured a more gradual reduction of peripheral vascular resistance and the most pronounced increase of cerebrovascular reserve capacity compared with the two remaining regimens. It is concluded that the parameters of peripheral vascular resistance and metabolic indices of cerebrovascular responsiveness are the most sensitive and informative end points for the pharmacotherapeutic treatment of cerebral hemodynamics in the patients presenting with grade II-III arterial hypertension and high risk of development of cardiovascular complications.

[Q-T interval dispersion in patients with coronary heart disease in various terms after angioplastic revascularization].

According to epidemiological researches data, in 75-80% of coronary heart disease (CHD) cases, the cause of sudden death is ventricular rhythm disturbances. Degree of coronary arteries lesion plays an important role in development of these disturbances. Study of Q-T interval dispersion is one of prospective methods of noninvasive assessment of risk of occurrence of dangerous for life ventricular arrhythmias. The authors studied indices of Q-T interval end its parts dispersion in patients with coronary atherosclerosis, and also estimated influence of angioplastic myocardial revasculization on electrical instability markers during 6 months after intracoronary intervention. It was proved that coronary atherosclerosis in patients with CHD contributes to increase of degree of myocardial depolarization and repolarization nonhomogeneity. Value of Q-T interval and its parts dispersion does not depend on number of affected coronary arteries. Revascularization of myocardium contributes to reliable decrease of Q-T interval and its parts dispersion. More marked its decrease is registered in 6 months after transcutaneous intracoronary intervention. Development of restenosis is accompanied by increase of indices of Q-T interval and its parts dispersion.