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Bull Exp Biol Med ; 129(6): 556-8, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-11022248

RESUMO

Age-related and thymus-dependent regulation of telomerase activity was studied in the bone marrow of normal (physiological aging) and thymectomized (experimental aging) mice. There was no strong correlation between the age and telomerase activity in bone marrow cells of normal mice. We observed only small individual differences in telomerase activity. Thymectomy 2-fold increased telomerase expression in young (2-month-old) and old (24-month-old) animals. Individual differences in telomerase activity in the bone marrow of thymectomized mice were more pronounced and did not depend on the age. The role of the thymus in cell aging is discussed.


Assuntos
Envelhecimento , Células da Medula Óssea/enzimologia , Telomerase/metabolismo , Timectomia , Animais , Ativação Enzimática , Feminino , Humanos , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA
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