[[Elimination of toxins from the body using electrochemical oxidation]. / Udalenie toksinov iz organizma s pomoshch'iu élektrokhimicheskogo okisleniia.

Potentialities of electrochemical procedures were considered in simulation of liver monooxygenases functions directed to clearance of blood and tissues from toxic and ballast substances by means of hydroxylating oxidation. Electrooxidation of specific endogenous toxin bilirubin, catalyzed by platinum electrode, was studied in model physiological solutions, blood, lymph and blood plasma. Three problems developed during direct electrooxidation of toxins in blood: efficiency of electrochemical cell, "protein protection" of the toxin, compatibility of electrochemical cell and blood. Influences of electrochemical oxidation on various patterns of intact animal homeostasis were studied as well as efficiency of the oxidation in a body was shown. Artificial detoxicating system was elaborated for clinical purpose using these experimental data.

[Indirect electrochemical oxidation using active oxygen carriers in a model of detoxicating function of the liver]. / Nepriamoe élektrokhimicheskoe okislenie s ispol'zovaniem perenoschikov aktivnogo kisloroda v modeli detoksitsiruiushchei funktsii pecheni.

As development of the electrochemical model of liver tissue monooxygenase system met with a serious problem of compatibility between electrochemical unit and blood, a procedure of indirect electrochemical oxidation of blood was proposed where carriers of active oxygen were used. Blood did not contact with the electrochemical system and electrolysis occurred in solution of oxygen carrier (0.89% NaCl), which accumulated active oxygen in the form of sodium hypochlorite. Sodium hypochlorite, administered into patients, enabled to bypass "the effect of protein protection" of toxic metabolites; it simulated both liver tissue monooxygenase functions and phagocytosis molecular mechanisms.