[The cAMP system in the cerebral cortex of irradiated rats in increased exogenous K+ levels]. / Sistema cAMP v tkani kory golovnogo mozga obluchennykh krys pri povyshenii naruzhnoi kontsentratsii K+.

Treatment of grey matter of irradiated (0.21 Cl/kg) rats by 60 mM of KCl causing depolarization of cell membranes leads to the increase of the cAMP content and to the decrease of adenylatecyclase activity. Dynamics of the enzyme activity with an increase of the external KCl concentration in control is to a considerable extent similar to that after irradiation, though the latter is more pronounced and a time shift is observed for maximal increase of a cAMP content and cAMP phosphodiesterase activity.

[Metabolism of choline-containing phospholipids in microsome fractions of the rat brain in acute radiation injury]. / Obmen kholinsoderzhashchikh fosfolipidov fraktsii mikrosom golovnogo mozga krys v usloviiakh ostrogo luchevogo porazheniia.

A considerable increase in activation of CDP-dependent pathway of the phosphatidylcholine and sphingomyelin synthesis in the microsomal fraction of rat brain grey matter is established one hour after the acute radiation injury. The level of [14C] choline incorporation into phosphatidyl choline is twice as low under these conditions.

[Activity of Mg2+, Ca2+-ATPase and lipid concentration in the plasma membranes rat brain synaptosomes in the early stages of acute radiation injury]. / Aktivnost' Mg2+, Ca2+-ATP-azy i soderzhanie lipidov v plazmaticheskikh membranakh sinaptosom mozga krys na rannikh étapakh ostrogo luchevogo porazheniia.

It is established that an hour after total X-ray irradiation of animals in a dose of 0.21 C/kg the Ca2+ content increases in a homogenate and subcellular fractions of the nervous tissue. The activity of Mg2+, Ca2+-ATP-ase in synaptosome plasma membranes becomes 1.6 times as high as under normal conditions. Changes are also observed in the lipid composition of synaptosome plasma membranes: an increase of the phospholipids and cholesterol contents in the composition of total lipids. The cholesterol phospholipids ratio remains about 1.0. The activation energy of ATP hydrolysis by membrane preparations isolated from the brain tissue of irradiated animals increases as compared to the normal level. It is supposed that variations in characteristics of the lipid bilayer in synaptosome plasma membranes are one of the reasons of changes in the activity of Mg2+, Ca2+-ATP-ase caused by irradiation.