COMPLEX HEAVY METAL SALTS' EFFECT ON GANGLION NUCLEI NEURONS MORPHOLOGICAL FUNCTIONS IN ADULT MALE RATS' CEREBELLAR CORTEX.

In order to analyze the dynamics of morphological and morphometric nuclear rearrangements of cortical cerebellar Purkinje cells under prolonged exposure (for 90 days) on the body of copper sulfate, zinc and iron experiment was conducted on 48 white adult male rats weighing 200-250g, aged 5 -8 months. We used anatomic, morphometric, statistical and common methods of micro anatomical research method. It was found that the combined effect of copper sulfate, zinc and iron on the body has nuclear device ganglion neurons in the cerebellar cortex sufficiently expressive toxicity, which affects the state of neurons. The degree of morphological rearrangements in the nuclear unit is in direct proportion to the duration of the experiment. In the nuclei of ganglion neurons develop nonspecific changes of polymorphic nature, which is reversible in the early stages of experience and irreversible, mainly necrobiotic character (chromatolysis, pycnosis and reksis) in most of the neurons within a timeline.

[MORPHOFUNCTIONAL ADJUSTMENT VASCULAR AND CELLULAR COMPONENTS OF THE CEREBELLAR CORTEX IN EXPOSURE TO BODY SULFATES OF COPPER, ZINC AND IRON].

In order to analyze the morphological and morphometric reconstructions of the vascular bed, and Purkinje cells of the cerebellar cortex of rats in long-term action (for 90 days) on the body of sulphates of copper, zinc and iron, an experiment was conducted on 48 adult white male rats weighing 200-250 g in age 5-7 months. We used anatomical, morphometric, statistical and common methods of microanatomical research. It was found that the combined effect on the body of sulphates of copper and zinc, and iron in the cerebellum has enough expressive toxicity, which affects the condition of the vascular bed, and Purkinje cells. The degree of morphological transformations is in direct proportion to the duration of the experiment. In the pathogenesis of violations leading role played by hypoxia, develop signs of swelling of the cerebellar cortex with signs hemorrhagic infiltration, the severity of which is maximum on the 60th day of the experiment.