1.
Org Lett
; 12(19): 4328-31, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20795632
RESUMO
A convergent stereoselective synthesis of a C1/C14 bis-epimer of uprolide D is described in which an intramolecular Barbier-type reaction was employed for macrocyclization with concomitant introduction of the C1 and C14 stereocenters of a fused α-methylene lactone ring through an anti-Felkin-Anh transition state. Unlike previous examples of allyl chromium additions, none of the Felkin-Anh derived adduct could be detected.