RESUMO
There are several excellent alternatives to warfarin on the horizon for atrial fibrillation. Results from the trials, as well as pharmacokinetic data from the edoxaban studies, suggest that dose selection, based on pharmacokinetic and pharmacodynamic properties, is a critical component in the development of novel anticoagulants. Greater flexibility in dosing with edoxaban and the opportunity for dose adjustment throughout the ENGAGE AF-TIMI 48 trial may be advantageous in the competitive field of novel oral anticoagulants.
Existen excelentes alternativas al tratamiento con warfarina en el campo de la fibrilación auricular. Los resultados de los ensayos con RE-LY, ROCKET-AF y ARISTOTLE, así como los datos fármaco cinéticos obtenidos en estudios con edoxaban, sugieren que la selección de la dosis, basada en propiedades fármaco cinéticas y fármaco dinámicas, es un componente crítico en el desarrollo de nuevos anticoagulantes. Una mayor flexibilidad en establecer la dosis de edoxaban y la oportunidad de ajustar la dosis mediante ENGAGE AF-TIMI 48, puede constituir una ventaja en el campo de los nuevos anticoagulantes orales.
Assuntos
Humanos , Anticoagulantes/administração & dosagem , Fibrilação Atrial/tratamento farmacológico , Administração OralRESUMO
There are several excellent alternatives to warfarin on the horizon for atrial fibrillation. Results from the trials, as well as pharmacokinetic data from the edoxaban studies, suggest that dose selection, based on pharmacokinetic and pharmacodynamic properties, is a critical component in the development of novel anticoagulants. Greater flexibility in dosing with edoxaban and the opportunity for dose adjustment throughout the ENGAGE AF-TIMI 48 trial may be advantageous in the competitive field of novel oral anticoagulants.