RESUMO
This study compared the efficacy and safety of etodolac, a new nonsteroidal anti-inflammatory drug of the pyranocarboxylic class, with that of diclofenac in patients with osteoarthritis of the knee. A total of 172 patients entered this double-blind, parallel study and were randomly assigned to receive etodolac 600 mg/day (n = 85) or diclofenac 150 mg/day (n = 87) for 8 weeks. Both treatment groups showed a statistically significant reduction in pain at the second week and significant improvement (P < or = 0.05) from baseline in all efficacy assessments for the remainder of the study. Seventeen (20%) patients in the etodolac group and 21 (24%) patients in the diclofenac group reported at least one adverse event. Seven (8%) patients treated with etodolac and eight (9%) of those receiving diclofenac withdrew prematurely from the trial. One diclofenac-treated patient had a significant increase in alanine aminotransferase at the final evaluation. The results of this study indicate that etodolac was well tolerated and as effective as diclofenac in relieving the signs and symptoms of osteoarthritis.
Assuntos
Diclofenaco/uso terapêutico , Etodolac/uso terapêutico , Articulação do Joelho , Osteoartrite/tratamento farmacológico , Adolescente , Adulto , Idoso , Método Duplo-Cego , Feminino , Humanos , Articulação do Joelho/fisiopatologia , Masculino , Pessoa de Meia-Idade , Osteoartrite/fisiopatologia , Medição da DorRESUMO
Verbal learning and forgetting were studied in patients one month after an episode of Transient Global Amnesia and in normal control subjects by means of a two-stage stochastic model, which allows independent measurements of encoding, storage and forgetting. We preliminarily ascertained both the necessity and the sufficiency of the model to account for several performance scores of the two experimental groups, and then compared the learning and forgetting functions between groups. In spite of the analytical power of the statistical method adopted. Transient Global Amnesia was not found to entail persistent impairment of encoding and storage, as well as of retaining memory traces and retrieval algorhythm.
Assuntos
Ataque Isquêmico Transitório/psicologia , Rememoração Mental , Retenção Psicológica , Aprendizagem Verbal , Córtex Cerebral/fisiopatologia , Feminino , Humanos , Ataque Isquêmico Transitório/fisiopatologia , Masculino , Rememoração Mental/fisiologia , Pessoa de Meia-Idade , Testes Neuropsicológicos/estatística & dados numéricos , Aprendizagem por Associação de Pares/fisiologia , Psicometria , Valores de Referência , Retenção Psicológica/fisiologia , Percepção da Fala/fisiologia , Aprendizagem Verbal/fisiologiaRESUMO
A brief introduction outlines the sources of radionuclides in the environment, their diffusion and transfer to different environmental compartments and their pathways to individuals; definitions of the main quantities and measurement units used in the study are included. A review is given on published data concerning the radioactive contamination of human milk after the Chernobyl accident. The authors' investigation on breast milk contamination in Italy in the same period is discussed together with an examination of the natural radioactive content. Finally, possible future developments and prospects of the research on this issue are explored.
