RESUMO
During a 5-year follow-up of rescue party members exposed to radioactive effects of the Chernobyl accident no material changes were observed versus healthy donors in the content of calcium, cholesterol, atherogenic lipoproteins, dienic conjugates, insulin, thyroxin, triiodothyronine, thyroglobulin, IgA, IgG and fibrinogen. Inhibition of peroxidation and emergence of hypocoagulation are attributed to a reduced respiratory splash of the neutrophils. Concentrations of hydrocortisone, testosterone, IgM rose, while the activity of some antioxidant enzymes remained stable.
Assuntos
Acidentes de Trabalho , Contaminação Radioativa do Ar/efeitos adversos , Células Sanguíneas/efeitos da radiação , Sangue/efeitos da radiação , Reatores Nucleares , Centrais Elétricas , Adulto , Antioxidantes/efeitos da radiação , Células Sanguíneas/fisiologia , Fenômenos Fisiológicos Sanguíneos , Aberrações Cromossômicas , Humanos , Peroxidação de Lipídeos/efeitos da radiação , Masculino , Pessoa de Meia-Idade , Fatores de Tempo , UcrâniaAssuntos
Circulação Cerebrovascular/efeitos dos fármacos , Transtornos Cerebrovasculares/tratamento farmacológico , Hemostasia/efeitos dos fármacos , Peroxidação de Lipídeos/efeitos dos fármacos , Adulto , Transtornos Cerebrovasculares/sangue , Transtornos Cerebrovasculares/fisiopatologia , Avaliação de Medicamentos , Feminino , Hemodinâmica/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Nicergolina/uso terapêutico , Niacinato de Xantinol/uso terapêuticoRESUMO
Literary data on the morphogenesis of prelipid changes in the basal arteries of the brain are scarce. This concerns also data on the antiaggregation activity of the vessel wall in this location. It was established that the antiaggregation activity of the vessel wall depended on the grade of its involvement by the atherosclerotic process. It was found that the higher the prelipid changes the lower was the antiaggregation activity of the vessel wall while the atherosclerotic plaques possess even proaggregation properties.
Assuntos
Artérias Cerebrais/fisiopatologia , Arteriosclerose Intracraniana/fisiopatologia , Adulto , Idoso , Artérias Cerebrais/ultraestrutura , Transtornos Cerebrovasculares/fisiopatologia , Humanos , Metabolismo dos Lipídeos , Microscopia Eletrônica , Pessoa de Meia-Idade , Infarto do Miocárdio/fisiopatologia , Reação do Ácido Periódico de Schiff , Agregação Plaquetária/fisiologiaRESUMO
The process of blood coagulation was found to be activated in the peroxidation syndrome caused by the use of antioxidant-free diet. Vasonin prevents the development of hypercoagulation in rabbits at the peroxidation syndrome but fails to prevent the development of the latter.
Assuntos
Hemostasia/efeitos dos fármacos , Peptídeos/farmacologia , Peróxidos/metabolismo , Animais , Vasos Sanguíneos , Dieta , Avaliação Pré-Clínica de Medicamentos , Eritrócitos/metabolismo , Fibrinólise/efeitos dos fármacos , Fígado/metabolismo , Oxirredução/efeitos dos fármacos , Peptídeos/uso terapêutico , Agregação Plaquetária/efeitos dos fármacos , Coelhos , SíndromeRESUMO
In a group of volunteers of different age, engaged in health-improving running for various time, a level of antioxidants and a capacity of vascular wall to synthesize the antiaggregating substances were increased as well as blood coagulation parameters were decreased. These alterations were especially important for men because of the favourable effect of the running on blood rheology and microcirculation as well as on metabolism of cell and tissues.