[Variants in the manifestations of the generalized form of yersiniosis]. / Varianty proiavlenii generalizovannoi formy iersinioza.

The clinical manifestations of generalized yersiniosis were studied in 61 patients. Primary generalized form was observed in 18 patients. Predecessors were gastroenteritis, appendicular syndrome. Clinical manifestations were polymorphous. All patients revealed fever and exanthema, 5%--catarrhal phenomena, 63.3%--lymphadenitis, 86%--arthralgia, 39.2%--gastrointestinal disorders, 114%--icteric syndrome. In 7.6% the course was protracted with recurrences of fever, exanthema, jaundice, diarrhea, formation of arthritis, Reiter's syndrome. Antibacterial treatment was carried out by aminoglycosides, cephalosporins.

[The importance of microbiological and immunologic studies for selecting the method of treating patients with acute pneumonia]. / Znachenie mikrobiologicheskikh i immunologicheskikh issledovanii dlia vybora metoda lecheniia bol'nykh ostroi pnevmoniei.

Quantitative microbiological examinations of the sputum allowed to establish the role of pneumococci and different bacterial associations in the development of acute pneumonia. The most typical were associations of Str. pneumoniae, staphylococci and neisseriae. The sensitivity of isolated pathogens is shown and recommendations on the use of most effective antibiotics are given. The indications to immunocorrective agents are outlined.

[Importance of associated microorganisms in the development of acute pneumonia]. / Znachenie assotsiatsii mikroorganizmov v razvitii ostrykh pnevmonii.

Sputum samples obtained from 106 patients with acute pneumonia have been studied by the quantitative microbiological method. Different microbial associations have been shown to play an important role in the development of acute pneumonia (67.9%). Microbiological studies have revealed the prevalence of pneumococci in the etiological structure of the disease. Staphylococci, hemophilic bacteria and Neisseria have been found to take part in the development of acute pneumonia in a lesser number of cases and more often occur in combination with pneumococci or form different associations themselves. The so-called "etiological" type of microbial associations has been determined, two or three microbial species being isolated at high concentrations (10(6) and over) and the percentage of patients with such combinations being 59.7 +/- 5.8%. The analysis of the clinical course of the disease has revealed that the presence of different microbial species in patients linked, to a great extent, with the clinical picture of the disease. These data may be used for prescribing adequate etiotropic therapy and for prognostication. Quantitative bacteriological studies carried out in the dynamics of the disease permit timely detection of changes in the microflora of the respiratory tracts, the evaluation of the effectiveness of antibacterial therapy in the process of its implementation and the rational correction of therapeutic measures.

[Microflora of the sputum and indicators of natural resistance in patients with acute pneumonia]. / Mikroflora mokroty i pokazateli estestvennoi rezistentnosti u bol'nykh ostroi pnevmoniei.

The paper is concerned with the results of quantitative studies on the sputum of 106 patients with acute pneumonia. Etiological structure of acute pneumonia, the dependence of a clinical course of disease on a sputum microflora composition type and some indices of natural resistance and immunity were shown.

[Sputum microflora in acute pneumonia based on the data from a quantitative study]. / Mikroflora mokroty pri ostroi pnevmonii po dannym kolichestvennogo issledovaniia.

In this work the data obtained in the quantitative investigations of sputum samples from 106 miners having acute pneumonia are presented. These investigations were carried out twice at the peak of the disease to determine the possible infective agent. The virological study of nasal impression smears by immunofluorescence and the serological study of paired sera made it possible to establish the viral and bacterial nature of the disease in 12% of cases. The expediency of the quantitative investigations of sputum, carried out twice, in combination with the study of the biological properties of opportunistic microorganisms was shown. Streptococcus pneumoniae proved to play the most important etiological role in the appearance of acute pneumonia in miners. This infective agent was detected in 82% of patients by the inoculation of sputum samples in "diagnostic" dilutions (10(-5) and higher). The associations of pneumococci with staphylococci, hemolytic bacteria and Neisseria were found to be capable of playing a significant role in the development of acute inflammation in pulmonary tissue, especially in those cases when these associations were isolated from highly diluted sputum (10(-5)).