RESUMO
The data on the photodamage of biomolecules and experimental tumours by a hematoporphyrin derivative activated with laser radiation are presented. Inhibition of the tumour growth and prolongation of the life-span of treated tumour-bearing animals are observed.
Assuntos
Fotorradiação com Hematoporfirina , Neoplasias Experimentais/tratamento farmacológico , Nucleotídeos/análise , Fotoquimioterapia , Animais , Feminino , Masculino , Camundongos , Camundongos Endogâmicos C3H , Camundongos Endogâmicos C57BL , Ratos , Ratos EndogâmicosRESUMO
187 female and male C57B1 mice received N-nitrosodipropylamine (NDPA) twice a week for 50 weeks by intragastric intubation. The total dose of NDPA administered to groups I and II was 3 mg or 1 mg per mouse. The main kinds of tumours in these groups were tumours of esophagus, forestomach, lungs, and lymphomas. The incidence of pulmonary adenomas and forestomach papillomas was more frequent in the group which received a higher dose of carcinogen.
Assuntos
Carcinógenos/toxicidade , Neoplasias Experimentais/induzido quimicamente , Nitrosaminas/toxicidade , Administração Oral , Animais , Relação Dose-Resposta a Droga , Feminino , Masculino , Camundongos , Camundongos Endogâmicos C57BLRESUMO
The angular distribution of the microwave absorption in normal and tumor (PC-1, Sa-45) tissues in the plane perpendicular or parallel to the body maximum size vector ----1 was investigated. The mechanism of microwave section induction by means of a "strong-radiation" slot was used to measure the angular distribution of microwave power. All types of tumor with the anisotropy factor K = 2 divided by 2.2 were shown to be characterised by a strong long-term anisotropy of absorption at ----E parallel 1 (where ----E--vector of electric field). In normal tissue anisotropy levels were lower (liver--K = 1.2; subcutaneous fat--K = 1.4).