RESUMO
The efficacy of praziquantel started during the incubation period of schistosomiasis has not been studied. Eighteen tourists were infected by Schistosoma haematobium during summer 2003 after bathing once in the same cascade in Mali. We observed the efficacy of praziquantel given at different phases. They received praziquantel at the first consultation, from Days 10 to 15 after exposure in eight asymptomatic patients (Group 1), from Days 28 to 40 in 4 asymptomatic patients (Group 2), and from Days 20 to 39 in 6 patients with acute schistosomiasis (Group 3). All Group 1 patients developed acute schistosomiasis, compared with none of the Group 2 patients (P < 0.004). Among the 10 patients treated during the acute phase, clinical status deteriorated in four cases. Seventeen of the 18 patients developed chronic schistosomiasis. Early praziquantel treatment was thus less effective than later treatment in preventing acute schistosomiasis, while neither treatment effectively prevented chronic schistosomiasis.
Assuntos
Anti-Helmínticos/administração & dosagem , Praziquantel/administração & dosagem , Esquistossomose Urinária/tratamento farmacológico , Adolescente , Adulto , Animais , Esquema de Medicação , Feminino , Humanos , Masculino , Mali , Schistosoma haematobium/patogenicidade , Esquistossomose Urinária/parasitologia , Esquistossomose Urinária/patologia , Índice de Gravidade de Doença , Viagem , Resultado do Tratamento , Microbiologia da ÁguaAssuntos
Infecções por HIV/tratamento farmacológico , Assistência de Longa Duração/métodos , Fármacos Anti-HIV/classificação , Fármacos Anti-HIV/farmacologia , Fármacos Anti-HIV/uso terapêutico , Contagem de Linfócito CD4 , Doença Crônica , Monitoramento de Medicamentos/métodos , Infecções por HIV/epidemiologia , Humanos , Seleção de Pacientes , Carga ViralRESUMO
The clinical spectrum of neurosyphilis is large. Serologic tests for syphilis are commonly indicated in diseases involving the central nervous system. The diagnosis of syphilis relies on epidemiological, clinical and biological grounds (cerebrospinal fluid abnormalities and RPR test). The treatment of neurosyphilis is still penicillin G.
Assuntos
Neurossífilis/diagnóstico , Antibacterianos/uso terapêutico , Líquido Cefalorraquidiano/microbiologia , Diagnóstico Diferencial , Humanos , Incidência , Neurossífilis/tratamento farmacológico , Neurossífilis/patologia , Penicilina G/uso terapêuticoRESUMO
BACKGROUND: Although respiratory tract infections represent a frequent cause of morbidity in travelers, and pneumonia a frequent cause of medical consultation among febrile travelers returning home, the etiologic spectrum of pneumonia in travelers has not been specifically studied. METHODS: We reviewed the medical charts of all travelers hospitalized during a 12-month period in our department with pneumonia after returning home. RESULTS: Seventeen patients (nine men, eight women, mean age 44 years, range 26 to 67 years) were included in this study. The etiology of pneumonia was established in 13 patients. Bacterial pneumonia was documented in 10 cases and was due to Streptococcus pneumoniae (n=2), Mycoplasma pneumoniae (n=2), Legionella pneumophila (n=1), Coxiella burnetti (n=1), Leptospira sp. (n=1) or Mycobacterium tuberculosis (n=3). Other etiologies included histoplasmosis, invasive schistosomiasis and dengue fever (one case each). CONCLUSION: These results show the wide range of causes of pneumonia among travelers returning from abroad.
