[Analysis of studies published on hypertension treatment non-compliance in Spain between 1984 and 2005]. / Análisis de los estudios publicados sobre el incumplimiento terapéutico en el tratamiento de la hipertensión arterial en España entre los años 1984 y 2005.

OBJECTIVE: To analyse therapy non-compliance in hypertension treatment in Spain, after a review of studies published between 1984 and 2005. DESIGN: Systematic review. DATA SOURCES: Data searches used Internet (Medline and Spanish index on doctoral these), a manual search of several Spanish journals, and bibliographic references to compliance from detected articles and through personal contact with experts. Descriptors used were: hypertension and patient compliance, compliance, adherence, patient drop-outs, treatment refusal, and their combinations. SELECTION OF STUDIES: Studies conducted in Spain and published between 1984 and 2005 were included, along with original articles, congress abstracts or doctoral theses, which used as a method of measurement pill count or counting of spaces in electronic monitoring systems, and which defined as non-compliers patients with a compliance percentage <80% and >110%. DATA EXTRACTION: The percentage of non-compliers was calculated, with 95% confidence intervals and weighted average of the percentage of non-compliers in each study. RESULTS: Twenty-six research studies published in Spain, excluding 2 analytical studies, were found. A total of 3553 patients with hypertension were included, of which 32.53% were non-compliers (n= 1156; 95 CI, 29.83-35.23) and 67.47% were compliers (n=2397; 95% CI, 65.67-69.27). The weighted average of non-compliance was at 32.78%. CONCLUSIONS: The percentage of therapy non-compliance in the treatment of hypertension in Spain has fallen in recent years, although it continues to be high.

Análisis de los estudios publicados sobre el incumplimiento terapéutico en el tratamiento de la hipertensión arterial en España entre los años 1984 y 2005 / Analysis of studies published on therapy non-compliance with hypertension treatment in Spain between 1984 and 2005

Objetivos. Analizar el incumplimiento farmacológico de la hipertensión arterial (HTA) en España, a partir de una revisión de estudios publicados entre 1984 y 2005. Diseño. Revisión sistemática. Fuentes de datos. Se realizó una búsqueda mediante internet (Medline e índice español de tesis doctorales), búsqueda manual de diferentes revistas españolas y referencias bibliográficas de artículos detectados sobre cumplimiento y contacto personalizado de expertos. Los descriptores fueron: hypertension and patient compliance, or compliance, or adherence, or patient dropouts or treatment refusal y sus combinaciones. Selección de estudios. Se incluyen estudios publicados entre 1984-2005, como artículos originales, resúmenes de congresos o tesis doctorales, realizados en España y que utilizaran como método de medida el recuento de comprimidos o el de aberturas de los monitores electrónicos (MEMS) y haber definido a los incumplidores, con un porcentaje de cumplimiento 110%. Extracción de datos. Se calcularon el porcentaje de incumplidores y sus intervalos de confianza (IC) del 95%, y la media ponderada del porcentaje de incumplidores de cada estudio. Resultados. Se ha obtenido un total de 26 estudios de investigación publicados en España, excluyéndose 2 del análisis. El número total de pacientes incluidos ha sido de 3.553 hipertensos, con un 32,53% de incumplidores (n = 1.156; IC del 95%, 29,83-35,23) y un 67,47% de cumplidores (n = 2.397; IC del 95%, 65,67-69,27). La media ponderada del porcentaje de incumplimiento fue del 32,78%. Conclusiones. El porcentaje de incumplimiento en el tratamiento farmacológico de la HTA en España ha descendido en los últimos años, aunque sigue siendo elevado

Objective. To analyse therapy non-compliance in hypertension treatment in Spain, after a review of studies published between 1984 and 2005. Design. Systematic review. Data Sources. Data searches used Internet (Medline and Spanish index on doctoral these), a manual search of several Spanish journals, and bibliographic references to compliance from detected articles and through personal contact with experts. Descriptors used were: hypertension and patient compliance, compliance, adherence, patient drop-outs, treatment refusal, and their combinations. Selection of studies. Studies conducted in Spain and published between 1984 and 2005 were included, along with original articles, congress abstracts or doctoral theses, which used as a method of measurement pill count or counting of spaces in electronic monitoring systems, and which defined as non-compliers patients with a compliance percentage 110%. Data extraction. The percentage of non-compliers was calculated, with 95% confidence intervals and weighted average of the percentage of non-compliers in each study. Results. Tweenty-six research studies published in Spain, excluding 2 analytical studies, were found. A total of 3553 patients with hypertension were included, of which 32.53% were non-compliers (n= 1156; 95 CI, 29.83-35.23) and 67.47% were compliers (n=2397; 95% CI, 65.67-69.27). The weighted average of non-compliance was at 32.78%. Conclusions. The percentage of therapy non-compliance in the treatment of hypertension in Spain has fallen in recent years, although it continues to be high