RESUMO
Recent research has suggested that autistic social impairment (ASI) is continuously distributed in nature and that subtle autistic-like social impairments aggregate in the family members of children with pervasive developmental disorders (PDDs). This study examined the longitudinal course of quantitatively characterized ASI in 3- to 18-year-old boys with and without PDD. We obtained assessments of 95 epidemiologically ascertained male-male twin pairs and a clinical sample of 95 affected children using the Social Responsiveness Scale (SRS), at two time points, spaced 1-5 years apart. Longitudinal course was examined as a function of age, familial loading for PDD, and autistic severity at baseline. Interindividual variation in SRS scores was highly preserved over time, with test-retest correlation of 0.90 for the entire sample. SRS scores exhibited modest general improvement over the study period; individual trajectories varied as a function of severity at baseline and were highly familial. Quantitative measurements of ASI reflect heritable traitlike characteristics. Such measurements can serve as reliable indices of phenotypic severity for genetic and neurobiologic studies, and have potential utility for ascertaining incremental response to intervention.
Assuntos
Transtorno Autístico/fisiopatologia , Transtorno Autístico/psicologia , Transtornos do Comportamento Social/fisiopatologia , Transtornos do Comportamento Social/psicologia , Adolescente , Envelhecimento/fisiologia , Envelhecimento/psicologia , Transtorno Autístico/genética , Criança , Pré-Escolar , Seguimentos , Humanos , Funções Verossimilhança , Estudos Longitudinais , Masculino , Modelos Psicológicos , Seleção de Pacientes , Valores de Referência , Índice de Gravidade de Doença , Irmãos , Comportamento Social , Transtornos do Comportamento Social/genética , Estudos em Gêmeos como AssuntoRESUMO
Autism spectrum disorders (ASDs) are characterized by correlated deficiencies in social and language development. This study explored a fundamental aspect of auditory information processing (AIP) that is dependent on social experience and critical to early language development: the ability to compartmentalize close-sounding speech sounds into singular phonemes. We examined this ability by assessing whether close-sounding non-native language phonemes were more likely to be perceived as disparate sounds by school-aged children with high-functioning ASD (n = 27), than by unaffected control subjects (n = 35). No significant group differences were observed. Although earlier in autistic development there may exist qualitative deficits in this specific aspect of AIP, they are not an enduring characteristic of verbal school-aged children with ASD.
Assuntos
Síndrome de Asperger/epidemiologia , Síndrome de Asperger/psicologia , Associação , Transtorno Autístico/epidemiologia , Transtorno Autístico/psicologia , Transtornos da Linguagem/epidemiologia , Desenvolvimento da Personalidade , Fonética , Reconhecimento Psicológico , Percepção da Fala , Conscientização , Criança , Transtornos Globais do Desenvolvimento Infantil/epidemiologia , Transtornos Globais do Desenvolvimento Infantil/psicologia , Cultura , Feminino , Humanos , Transtornos da Linguagem/diagnóstico , Masculino , Testes de Discriminação da FalaRESUMO
Insecure mental representations of attachment, a nearly invariant feature of cluster B personality disorders, have never previously been studied in twins. We conducted the Adult Attachment Interview (AAI) on 33 pairs of monozygotic (MZ) female twins reared together as an initial exploration of causal influences on mental representations of attachment. As predicted by attachment theory, we observed substantial twin-twin concordance for attachment security (odds ratio 13.8; P = 0.001), a similar level of concordance between twins and their non-twin siblings, and an inverse relationship between attachment security and current level of aggression (P = 0.01). These data indicate that there are minimal effects of non-shared environmental influences (or measurement error) on attachment classifications derived from the AAI. In this sample of twins with and without histories of Conduct Disorder, mental representations of attachment appear to be highly familial, i.e., strongly influenced by either shared environmental factors, genetic factors, or both.
Assuntos
Cognição , Transtorno da Conduta/epidemiologia , Transtorno da Conduta/psicologia , Apego ao Objeto , Gêmeos Monozigóticos/psicologia , Adolescente , Adulto , Demografia , Feminino , Humanos , Variações Dependentes do Observador , PrevalênciaRESUMO
Studies of the broader autism phenotype, and of subtle changes in autism symptoms over time, have been compromised by a lack of established quantitative assessment tools. The Social Responsiveness Scale (SRS-formerly known as the Social Reciprocity Scale) is a new instrument that can be completed by parents and/or teachers in 15-20 minutes. We compared the SRS with the Autism Diagnostic Interview-Revised (ADI-R) in 61 child psychiatric patients. Correlations between SRS scores and ADI-R algorithm scores for DSM-IV criterion sets were on the order of 0.7. SRS scores were unrelated to I.Q. and exhibited inter-rater reliability on the order of 0.8. The SRS is a valid quantitative measure of autistic traits, feasible for use in clinical settings and for large-scale research studies of autism spectrum conditions.
