Visuospatial perspective taking in people with Down syndrome.

Visuospatial perspective taking (VPT) refers to the process of mentally representing a viewpoint different from one's own. It is related to mental rotation and theory of mind and helps to support some complex spatial activities such as wayfinding. Despite research advances in spatial cognition, little is known about VPT in people with Down syndrome (DS). Here, we examined VPT in people with DS. A total of 38 individuals with DS (aged 12-25 years old) and nonverbal ability-matched typically developing (TD) children (aged 4-9 years old) participated. They completed two VPT tasks: the classic Piagetian Three Mountains Task and a modified version of the "Dog Task" (Newcombe & Huttenlocher, 1992). For both groups, the Three Mountains Task was more difficult than the Dog Task, implying the impact of task complexity on assessing VPT. However, the overall performance did not differ between the TD and DS groups in either VPT task. Implications of the results were discussed.

Informal STEM learning: Examples from everyday spatial behaviors.

Introduction: Extensive research has shown a close relationship between spatial abilities and success in STEM disciplines because many STEM problems often require students to reason about spatial information. Everyday spatial behaviors may predate and facilitate the development of spatial skills. Therefore, the current study examined children's everyday spatial behaviors and their associations with broader child development outcomes and individual differences. Methods: Based on previous research, we developed an everyday spatial behaviors questionnaire for children (ESBQC). A total of 174 parents and their children aged 4-9 years old participated. In ESBQC, parents rated how much difficulty their children experience with different spatial behaviors, such as putting together a puzzle, retracing a route, or hitting a moving ball. Results: Factor analysis revealed 8 components in ESBQC. The internal reliabilities were relatively high. ESBQC was positively correlated with age but not with sex. Furthermore, ESBQC predicted sense of direction, even after considering age and bias associated with parent reports. Discussion: Our questionnaire may provide a useful tool for parents and other stakeholders to better understand everyday spatial behaviors and encourage interest and competence in spatial skills, ultimately promoting STEM learning in informal, everyday settings.

Technology for assessment and treatment of justice-involved youth: A systematic literature review.

OBJECTIVE: We conducted a systematic literature review of e-mental health technologies in juvenile justice contexts. HYPOTHESES: Our exploratory research questions were as follows: First, what types of e-mental health exist for justice-involved youth, their caregivers, and juvenile justice professionals? Second, what are the characteristics of studies that have examined these technologies? Third, what have studies found about the effectiveness, reliability, or validity of e-mental health in treating and assessing juvenile justice populations? And fourth, what advantages and disadvantages exist for e-mental health use in juvenile justice? METHOD: We screened 759 articles and retained 36 for review. We included articles that investigated e-mental health for the assessment or treatment of justice-involved youth and their caregivers. We excluded technologies not directly related to assessment or treatment as well as samples of at-risk youth with no justice involvement. RESULTS: We identified four types of e-mental health technologies: Interventions with technology-facilitated interpersonal communication (e.g., telehealth and mHealth), digitized intervention programs, simulation games, and computerized assessments. Most study designs were experimental/quasi-experimental or qualitative/descriptive, followed closely by repeated measures/pretest-posttest. A majority of evidence suggested that e-mental health technologies were potentially effective or valid for treatment and assessment, especially telehealth. Advantages included positive opinions of users, increased access to care, and efficiency; disadvantages included barriers to accessing technology, privacy concerns, and lack of clear effectiveness, reliability, or validity data. CONCLUSIONS: Although the available evidence for e-mental health for juvenile justice is promising, the current literature base appears generally underdeveloped and nuanced. Worthwhile future directions include continued development of technologies and more rigorously conducted studies to support further implementation of e-mental health for juvenile justice. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Do laypeople recognize youth as a risk factor for false confession? A test of the 'common sense' hypothesis.

In a survey of confession experts, 94% agreed that youth is a risk factor for false confession, but only 37% felt that jurors understand this. To date, no study has tested the latter by comparing laypeople's perceptions of juvenile and adult suspects. To address this gap, Experiment 1 participants read a lengthy (i.e. interrogation and confession) or abridged (i.e. confession-only) transcript of an ostensibly juvenile or adult suspect's interrogation. Transcript length affected perceived pressure but not guilt judgments. Suspect age had little effect, with 75% of participants misjudging the juvenile as guilty. Experiment 2 then tested how expert testimony affects judgments of juvenile suspects. Participants read a lengthy or abridged interrogation transcript, with or without testimony from a juvenile confession expert. Expert testimony somewhat impacted guilt judgments but did not influence perceptions of the interrogation. Implications for interrogation practices, trial procedure and future research are discussed.

HER3 Differentiates Basal From Claudin Type Triple Negative Breast Cancer and Contributes to Drug and Microenvironmental Induced Resistance.

Triple Negative Breast Cancer (TNBC) is an aggressive form of Breast Cancer (BC). Numerous kinase inhibitors (KI) targeting different pathway nodes have shown limited benefit in the clinical setting. In this study, we aim to characterize the extent of HER3 reliance and to define the effect of Neuregulin (NRG) isoforms in TNBCs. Basal and Claudin type TNBC cell lines were treated with a range of small molecule inhibitors, in the presence or absence of the HER3 ligand NRG. Single agent and combination therapy was also evaluated in human cancer cell lines through viability and biochemical assessment of the AKT/MAPK signaling pathway. We show that Basal (BT20, HCC-70, and MDA-MB-468) and Claudin type (MDA-MB-231, BT-549) TNBC cell lines displayed differential reliance on the HER family of receptors. Expression and dynamic HER3 upregulation was predominant in the Basal TNBC subtype. Furthermore, the presence of the natural ligand NRG showed potent signaling through the HER3-AKT pathway, significantly diminishing the efficacy of the AKT and PI3K inhibitors tested. We report that NRG augments the HER3 feedback mechanism for continued cell survival in TNBC. We demonstrate that combination strategies to effectively block the EGFR-HER3-AKT pathway are necessary to overcome compensatory mechanisms to NRG dependent and independent resistance mechanisms. Our findings suggests that the EGFR-HER3 heterodimer forms a major signaling hub and is a key player in tumorigenesis in Basal but not Claudin type TNBC tested. Thus, HER3 could potentially serve as a biomarker for identifying patients in which targeted therapy against the EGFR-HER3-AKT axis would be most valuable.

Weak functional connectivity in the human fetal brain prior to preterm birth.

It has been suggested that neurological problems more frequent in those born preterm are expressed prior to birth, but owing to technical limitations, this has been difficult to test in humans. We applied novel fetal resting-state functional MRI to measure brain function in 32 human fetuses in utero and found that systems-level neural functional connectivity was diminished in fetuses that would subsequently be born preterm. Neural connectivity was reduced in a left-hemisphere pre-language region, and the degree to which connectivity of this left language region extended to right-hemisphere homologs was positively associated with the time elapsed between fMRI assessment and delivery. These results provide the first evidence that altered functional connectivity in the preterm brain is identifiable before birth. They suggest that neurodevelopmental disorders associated with preterm birth may result from neurological insults that begin in utero.

Age-related increases in long-range connectivity in fetal functional neural connectivity networks in utero.

Formation of operational neural networks is one of the most significant accomplishments of human fetal brain growth. Recent advances in functional magnetic resonance imaging (fMRI) have made it possible to obtain information about brain function during fetal development. Specifically, resting-state fMRI and novel signal covariation approaches have opened up a new avenue for non-invasive assessment of neural functional connectivity (FC) before birth. Early studies in this area have unearthed new insights about principles of prenatal brain function. However, very little is known about the emergence and maturation of neural networks during fetal life. Here, we obtained cross-sectional rs-fMRI data from 39 fetuses between 24 and 38 weeks postconceptual age to examine patterns of connectivity across ten neural FC networks. We identified primitive forms of motor, visual, default mode, thalamic, and temporal networks in the human fetal brain. We discovered the first evidence of increased long-range, cerebral-cerebellar, cortical-subcortical, and intra-hemispheric FC with advancing fetal age. Continued aggregation of data about fundamental neural connectivity systems in utero is essential to establishing principles of connectomics at the beginning of human life. Normative data provides a vital context against which to compare instances of abnormal neurobiological development.