Contamination skin doses and attenuation of radiation by clothing.

The potential operating environment following an attack using CBRN (chemical, biological, radiological, nuclear) materials has led to design work aiming to reduce the physiological burden of protective clothing, while maintaining satisfactory levels of chemical protection. In this paper, we review the radiological protection provided by these lighter, thinner clothing options. Monte Carlo modelling has been used to determine the contribution to skin dose from both beta and gamma radiation from four sources, each with different emission characteristics. The protection factors for eight materials have been characterised in terms of the surface density of each material (ranging from 50 to 482 g m⁻²). As protective clothing is made lighter and more breathable, the radiological protection is significantly reduced. This work has provided quantitative analysis of the magnitude of this reduction. A simple algorithm has been derived which can be used to estimate the protection factor for any clothing, on the basis of the surface density of the material (within the range of materials studied). These results show the need for skin radiation exposure to be considered by protective suit designers and CBRN response planners.

Galactorrhea-amenorrhea syndrome: follow-up of forty-five patients after pituitary tumor removal.

Forty-five patients with galactorrhea-amenorrhea were followed during a period of 1 to 8 years (mean 3.1) after transsphenoidal prolactinoma removal. The ratios of patients who appear to be cured to the total numbers treated were 20 patients of 27 with grade I tumors; six of 10 with grade II; two of five with grade III; and none with grade IV tumors. Six patients with normal prolactin levels one week postoperatively had relapse later, as did three with normal prolactin levels 2 months postoperatively. A normal prolactin level 6 months postoperatively predicted ultimate cure. The 19 pregnancies that occurred in 15 patients, four with high prolactin levels, were uneventful. Prolactin rose normally with pregnancy and returned to prepregnancy level in all but one patient. Prolactin responses to stimulation tests were blunted for 6 months after successful tumor removal. By 1 year, responses to thyrotropin releasing hormone and metoclopramide tests were returning to normal, although responses to chlorpromazine and hypoglycemia remained blunted. The postoperative inhibition of normal lactotropes for 6 months is suggested. Ultimate cure cannot be determined before 6 months and conception should be deferred until then.

The treatment of acromegaly by transsphenoidal surgery.

Pituitary tumors were removed transsphenoidally in 32 patients with acromegaly. Ten patients had high prolactin (PL) levels as well as elevated growth hormone (GH) levels. In 24 patients, GH levels were lowered to 5 ng/mL or less and remained low. The PL level was reduced to normal in eight patients. Of three patients with postoperative GH levels of 6 to 10 ng/mL, one patient remains in this range but two have relapsed. Five patients showed only a partial lowering in GH level. Pituitary irradiation lowered the level further. Hypopituitarism developed in four patients. Permanent diabetes insipidus occurred in one patient and meningitis developed in another. They subsequently recovered. There were no deaths. Abnormal GH responses to hyperglycemia, hypoglycemia, and levodopa returned to normal following surgery. Transsphenoidal tumor removal appears to be an effective treatment for acromegaly.