Printing medicines as orodispersible dosage forms: Effect of substrate on the printed micro-structure.

We present our recent advancements in developing a viable manufacturing process for printed medicine. Our approach involves using a non-contact printing system that incorporates both piezoelectric- and solenoid valve-based inkjet printing technologies, to deliver both active and inactive pharmaceutical materials onto medical-graded orodispersible films. By using two complimentary inkjet technologies, we were able to dispense an extensive range of fluids, from aqueous drug solutions to viscous polymer coating materials. Essentially, we demonstrate printing of a wide range of formulations for patient-ready, orodispersible drug dosage forms, without the risk of drug degradation by ink heating and of substrate damages (by contact printing). In addition, our printing process has been optimized to ensure that the drug doses can be loaded onto the orally dissolvable films without introducing defects, such as holes or tears, while retaining a smooth surface texture that promotes patient adherence and allows for uniform post-coatings. Results show that our platform technology can address key issues in manufacturing orodispersible drug dosage forms and bring us closer to delivering personalized and precision medicine to targeted patient populations.

Synthesis, catalytic activity, and leaching studies of a heterogeneous Pd-catalyst including an immobilized bis(oxazoline) ligand.

The synthesis and characterization of a novel catalytic system including Pd(OAc)(2) attached to a bis(oxazoline) (=BOX) ligand that is covalently bonded to 3-mercaptopropyl-functionalized silica gel is presented. The catalyst was tested for Suzuki-Miyaura reactions of different aryl halides with phenylboronic acid. The heterogeneity of the catalytic system was investigated using different approaches, indicating that there is virtually no Pd leaching into the reaction solution under the applied reaction conditions. Furthermore, our results show that the catalytic system can be reused multiple times without significant loss of stability or structure.