Assuntos
Anormalidades Múltiplas/genética , Hibridização de Ácido Nucleico/métodos , Translocação Genética , Anormalidades Múltiplas/diagnóstico , Bandeamento Cromossômico , Cromossomos Humanos Par 4/ultraestrutura , Cromossomos Humanos Par 8/ultraestrutura , Humanos , Hibridização in Situ Fluorescente , Recém-Nascido , Masculino , SíndromeRESUMO
We report on two cases of female pseudohermaphroditism associated with anorectal, Müllerian duct, and urinary tract malformations. We suggest that this form of female pseudohermaphroditism is an extreme manifestation of the caudal type of VATER association.
Assuntos
Transtornos do Desenvolvimento Sexual/genética , Transtornos do Desenvolvimento Sexual/fisiopatologia , Adulto , Doenças em Gêmeos/genética , Transtornos do Desenvolvimento Sexual/patologia , Feminino , Humanos , Ovário/metabolismo , Ovário/patologia , Cromossomo X/genéticaRESUMO
An anthracycline-induced cardiomyopathy can already appear at a total cumulative dose of less then 550 mg/m2. Noninvasive cardiological methods have been used in order to detect these fatal side effects early. For cardiological control we applied echo-cardiography with measurements of ventricular size and left ventricular function. 5 out of 39 children who were off anthracycline therapy for 3 months to 8 years showed a decline in left ventricular function, but no clinical symptoms. At present 16 children with anthracycline therapy are controlled by echocardiography. In 2 patients a transient myocardial dysfunction was diagnosed. After stopping anthracycline therapy the left ventricular function improved within 2 to 3 months without specific cardiac treatment.
Assuntos
Antibióticos Antineoplásicos/efeitos adversos , Cardiomiopatias/induzido quimicamente , Ecocardiografia , Neoplasias/tratamento farmacológico , Adolescente , Adulto , Antibióticos Antineoplásicos/administração & dosagem , Criança , Pré-Escolar , Relação Dose-Resposta a Droga , Feminino , Seguimentos , Hemodinâmica/efeitos dos fármacos , Humanos , Neoplasias Renais/tratamento farmacológico , Leucemia/tratamento farmacológico , Linfoma não Hodgkin/tratamento farmacológico , Masculino , Sarcoma/tratamento farmacológico , Tumor de Wilms/tratamento farmacológicoRESUMO
314 children with hypertension living in an urban district have been transmitted to our out patient clinic. These children were discovered by regularly performed examinations of the medical youth care since 1979. We found a secondary cause of hypertension in 2.2 per cent. Risk factors, as for example familiar disposition, hyperlipidaemia, smoking and overweight, were also analysed. A dynamic exercise-test was performed by means of bicycle-ergometry. 43 per cent of the children with elevated blood pressure in rest reacted with hypertension during exercise. Criteria for drug-therapy were the unsuccessful non-medicamentous effects on the hypertension and a hypertension exercise-test. After 2-5 years 55.9 per cent of all children with elevated blood pressure of the beginning of our study became normotensive without drug-therapy.
