[A case report of plasma cell granuloma in maxillary sinuses].

Plasma cell granuloma is a kind of the disease with low incidence at head and neck，which is a benign lesions with malignant biological performance. The diagnosis of plasma cell granuloma is difficult as the symptom is not typical and it is difficult to distinguish with cancers and other diseases through the physical sign and imaging manifestation. The golden standard of diagnosis is histopathological examination. The therapy of plasma cell granuloma is still controversial, but the first choice is the operation. The other therapy such as hormone therapy, radiotherapy, chemotherapy etc., should be applied according to special conditions. Surgery has advantage with high cure rate and very low reoccurance rate. In this paper, we reported a case of plasma cell granuloma, occurred in maxillary sinus and summarizes the experiences about diagnosis and therapy of plasma cell granuloma in maxillary sinus through review previous literature.

Analysis of protein-protein interaction network in chronic obstructive pulmonary disease.

Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality throughout the world. The purpose of our study was to uncover biomarkers and explore its pathogenic mechanisms at the molecular level. The gene expression profiles of COPD samples and normal controls were downloaded from Gene Expression Omnibus. Matlab was used for data preprocessing and SAM4.0 was applied to determine the differentially expressed genes (DEGs). Furthermore, a protein-protein interaction (PPI) network was constructed by mapping the DEGs into PPI data, and functional analysis of the network was conducted with BiNGO. A total of 348 DEGs and 765 interactive genes were identified. The hub genes were mainly involved in metabolic processes and ribosome biogenesis. Several genes related to COPD in the PPI network were found, including CAMK1D, ALB, KIT, and DDX3Y. In conclusion, CAMK1D, ALB, KIT, and DDX3Y were chosen as candidate genes, which have the potential to be biomarkers or candidate target molecules to apply in clinical diagnosis and treatment of COPD.