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1.
Blood Purif ; 31(1-3): 107-12, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21228577

RESUMO

In elderly subjects and patients with end-stage renal disease (ESRD), carotid pulse pressure (PP) is an independent and significant predictor of cardiovascular (CV) risk. Whereas in the elderly carotid diameter, but not carotid stiffness, is an associated CV risk factor, an opposite CV risk pattern was observed in ESRD patients that was associated with stiffness. Whether in ESRD patients arterial diameter, stiffness or both are involved in the mechanism(s) of increased carotid PP has never been investigated. Nondiabetic ESRD patients (n = 144) were compared with 57 control subjects matched for age, sex and mean blood pressure, but with higher brachial and carotid PP. Noninvasive echo-Doppler techniques and pulse wave velocity (PWV) and pulse wave analysis were used to evaluate cardiac and carotid arterial structures and functions using multiple stepwise regressions. In controls, carotid PP was associated only with stroke volume, arterial wave reflections and aortic PWV, but not aortic diameter. In ESRD patients, it was associated with wave reflections, aortic PWV, stroke volume and higher aortic diameter. In ESRD patients and controls, elevated carotid PP mainly reflected increased aortic PWV and earlier wave reflections. Aortic diameter had an impact only on ESRD patients, where it compensated for enhanced aortic stiffness and the more pronounced effect of reflected waves. This hemodynamic profile differs consistently from that in elderly subjects of the general population and selectively influences CV risk and drug treatment.


Assuntos
Aorta/fisiopatologia , Artéria Carótida Primitiva/fisiopatologia , Falência Renal Crônica/fisiopatologia , Adulto , Pressão Sanguínea , Feminino , Hemodinâmica , Humanos , Masculino , Pessoa de Meia-Idade
2.
Clin Exp Pharmacol Physiol ; 34(7): 683-7, 2007 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-17581230

RESUMO

1. Patients with chronic kidney disease (CKD) demonstrate a high burden of vascular disease. This vascular disease is unusual by way of a preponderance of medial calcification. Further, traditional cardiovascular risk factors fail to fully explain the high cardiovascular event rate in this population. 2. The present review examines the problem of medial calcification and arterial stiffness evident in patients with CKD and explores evidence for its existence and the potential pathological process involved. Many factors are emerging as potential culprits in this disease entity, although the specific roles of components such as fetuin-A, matrix Gla protein, osteopontin and fibroblast growth factor-23 have yet to be determined. Calcium and phosphate balance remains integral to the pathological process. 3. Pulse wave velocity has proven to be a useful tool to assess and follow arterial stiffness in CKD patients and is discussed. 4. Finally, techniques aimed at reducing or reversing arterial calcification and stiffness are discussed, with as yet no definitive answers available.


Assuntos
Artérias/fisiopatologia , Calcinose/fisiopatologia , Doenças Cardiovasculares/etiologia , Nefropatias/complicações , Doenças Vasculares Periféricas/fisiopatologia , Calcinose/complicações , Calcinose/diagnóstico , Calcinose/etiologia , Calcinose/terapia , Doenças Cardiovasculares/fisiopatologia , Doença Crônica , Complacência (Medida de Distensibilidade) , Humanos , Nefropatias/fisiopatologia , Nefropatias/terapia , Doenças Vasculares Periféricas/complicações , Doenças Vasculares Periféricas/diagnóstico , Doenças Vasculares Periféricas/etiologia , Doenças Vasculares Periféricas/terapia , Fluxo Pulsátil , Fatores de Risco
3.
Eur J Clin Invest ; 35 Suppl 3: 85-8, 2005 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16281963

RESUMO

Epidemiological and clinical studies have shown that cardiovascular disease in patients with end-stage renal disease (ESRD) is frequently related to damage of large conduit arteries. Arterial disease is responsible for the high incidence of ischaemic heart disease, peripheral artery diseases, left ventricular hypertrophy and congestive heart failure. The vascular complications in ESRD are ascribed to two different but associated mechanisms, namely atherosclerosis and arteriosclerosis. Whereas the former principally affects the conduit function with ischaemic lesions being the most characteristic consequence, the latter primarily disturbs the dampening function of large arteries. Arteriosclerosis in ESRD patients is characterized by diffuse dilation and wall hypertrophy of large conduit arteries and stiffening of arterial walls. These changes represent a clinical form of an accelerated ageing process. The main clinical characteristics due to arterial stiffening are isolated increase in systolic blood pressure with normal or lower diastolic pressure resulting in an increased pulse pressure. The consequences of these alterations are: (i) an increased left ventricular afterload with development of left ventricular hypertrophy and increased myocardial oxygen demand; and (ii) altered coronary perfusion and subendocardial blood flow distribution. Epidemiological studies have identified arterial remodelling and stiffening as independent predictors of overall and cardiac mortality in ESRD patients.


Assuntos
Artérias/fisiopatologia , Arteriosclerose/fisiopatologia , Uremia/fisiopatologia , Artérias/patologia , Arteriosclerose/complicações , Arteriosclerose/patologia , Aterosclerose/complicações , Aterosclerose/patologia , Aterosclerose/fisiopatologia , Pressão Sanguínea/fisiologia , Circulação Coronária/fisiologia , Humanos , Falência Renal Crônica/complicações , Falência Renal Crônica/patologia , Falência Renal Crônica/fisiopatologia , Uremia/complicações , Uremia/patologia
4.
Minerva Urol Nefrol ; 56(3): 279-88, 2004 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-15467506

RESUMO

Cardiovascular disease is prevalent in patients with chronic kidney disease and may account for 50% of all deaths. Left ventricular hypertrophy is the most frequent cardiac alteration in end-stage renal disease (ESRD) patients. It is due to a combination of hemodynamic and humoral factors. Volume overload and pressure overload are responsible for adaptative alterations of the heart and the vessels consider as a unique functional system. These alterations are first beneficial but their persistence leads to a detrimental process, mainly cardiac dilation and failure. Treatment of the hemodynamic overload could partially stabilize or reverse this evolution.


Assuntos
Hipertrofia Ventricular Esquerda/etiologia , Falência Renal Crônica/complicações , Anemia/etiologia , Derivação Arteriovenosa Cirúrgica/efeitos adversos , Fibrose/etiologia , Humanos , Hipertensão/etiologia , Miocárdio/patologia , Disfunção Ventricular Esquerda/etiologia
5.
Hypertension ; 38(4): 938-42, 2001 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11641313

RESUMO

To test the predictive values of and independent contributions to cardiovascular and all-cause mortality of various arterial parameters exploring characteristics of the arterial wall at different sites, we studied prospectively 110 stable end-stage renal disease patients on hemodialysis. These parameters involved carotid diameter, carotid intima-media thickness, carotid compliance, carotid distensibility, carotid incremental elastic modulus, aortic diameter, aortic pulse wave velocity, and the presence of arterial calcifications measured at the sites of the carotid artery, abdominal aorta, iliofemoral axis, and legs. The presence of calcifications was analyzed semiquantitatively as a score (0 to 4) according to the number of arterial sites with calcifications. During a follow-up of 53+/-21 months (mean+/-SD), 25 cardiovascular and 14 noncardiovascular deaths occurred. In univariate analysis, the carotid incremental elastic modulus was the most closely related to prognosis. Risk of death increased with the number of vascular sites involved by calcifications. Moreover, information (in terms of prediction) given by carotid elastic incremental modulus was additive to the presence and extent of vascular calcification-related prediction value. Adjusted hazard ratios of all-cause and cardiovascular mortality for an increase of 1 unit in calcification score were 1.9 (95% confidence interval [CI], 1.4 to 2.6) and 2.6 (95% CI, 1.5 to 4.4), respectively (P<0.001 for both). Adjusted hazard ratios of all-cause and cardiovascular mortality for a 1-SD increase in carotid incremental elastic modulus were 1.6 (95% CI, 1.2 to 2.2) and 1.7 (95% CI, 1.2 to 2.4), respectively (P<0.01 for both). The results of this study showed that the presence and extent of vascular calcifications were strong predictors of cardiovascular and all-cause mortality. Carotid incremental elastic modulus gave additional predictive value.


Assuntos
Doenças Cardiovasculares/patologia , Doenças das Artérias Carótidas/patologia , Falência Renal Crônica/complicações , Adulto , Idoso , Calcinose/patologia , Doenças Cardiovasculares/complicações , Doenças Cardiovasculares/fisiopatologia , Doenças das Artérias Carótidas/complicações , Doenças das Artérias Carótidas/fisiopatologia , Estudos de Coortes , Feminino , Seguimentos , Humanos , Falência Renal Crônica/mortalidade , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Diálise Renal , Fatores de Risco , Índice de Gravidade de Doença , Análise de Sobrevida , Taxa de Sobrevida , Túnica Íntima/patologia
6.
Hypertension ; 38(3): 434-8, 2001 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-11566918

RESUMO

The increased effect of arterial wave reflections on central arteries like the common carotid artery seen in end-stage renal failure (ESRF) patients favors myocardial hypertrophy and oxygen consumption and alters coronary blood flow distribution. Nevertheless, the impact of wave reflection on the outcome and end points such as mortality remains to be demonstrated. One hundred eighty ESRF patients (age, 54+/-16 years) were monitored for 52+/-36 months (mean+/-SD). Seventy deaths, including 40 cardiovascular (CV) and 30 non-CV events, occurred. At entry, patients, in addition to standard clinical and biochemical analyses, underwent aortic pulse wave velocity measurement and determination of arterial wave reflexion by applanation tonometry on the common carotid artery that was expressed as augmentation index. Cox analyses demonstrated that predictors of all-cause and CV mortality were age, aortic pulse wave velocity, low diastolic blood pressure, preexisting CV disease, and increased augmentation index, whereas the prescription of an ACE inhibitor had a favorable effect on survival. After adjustment for all confounding factors, the risk ratio for each 10% increase in augmentation index was 1.51 (95% confidence interval, 1.23 to 1.86; P<0.0001) for all-cause mortality and 1.48 (95% confidence interval, 1.16 to 1.90; P<0.0001) for CV mortality. These results provide the first direct evidence that in ESRF patients increased effect of arterial wave reflections is an independent predictor of all-cause and CV mortality.


Assuntos
Artérias/fisiopatologia , Falência Renal Crônica/fisiopatologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Artérias/patologia , Velocidade do Fluxo Sanguíneo , Pressão Sanguínea/fisiologia , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/mortalidade , Doenças Cardiovasculares/fisiopatologia , Artéria Carótida Primitiva/patologia , Artéria Carótida Primitiva/fisiopatologia , Estudos de Coortes , Artéria Femoral/patologia , Artéria Femoral/fisiopatologia , Seguimentos , Humanos , Falência Renal Crônica/complicações , Falência Renal Crônica/mortalidade , Pessoa de Meia-Idade , Prognóstico , Análise de Sobrevida , Taxa de Sobrevida
7.
Circulation ; 103(7): 987-92, 2001 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-11181474

RESUMO

BACKGROUND: Aortic pulse wave velocity (PWV) is a predictor of mortality in patients with end-stage renal failure (ESRF). The PWV is partly dependent on blood pressure (BP), and a decrease in BP can attenuate the stiffness. Whether the changes in PWV in response to decreases in BP can predict mortality in ESRF patients has never been investigated. METHODS AND RESULTS: One hundred fifty ESRF patients (aged 52+/-16 years) were monitored for 51+/-38 months. From entry until the end of follow-up, the changes of PWV in response to decreased BP were measured ultrasonographically. BP was controlled by adjustment of "dry weight" and, when necessary, with ACE inhibitors, calcium antagonists, and/or beta-blockers, in combination if necessary. Fifty-nine deaths occurred, including 40 cardiovascular and 19 noncardiovascular events. Cox analyses demonstrated that independent of BP changes, the predictors of all-cause and cardiovascular mortality were as follows: absence of PWV decrease in response to BP decrease, increased left ventricular mass, age, and preexisting cardiovascular disease. Survival was positively associated with ACE inhibitor use. After adjustment for all confounding factors, the risk ratio for the absence of PWV decrease was 2.59 (95% CI 1.51 to 4.43) for all-cause mortality and 2.35 (95% CI 1.23 to 4.41) for cardiovascular mortality. The risk ratio for ACE inhibitor use was 0.19 (95% CI 0.14 to 0.43) for all-cause mortality and 0.18 (95% CI 0.06 to 0.55) for cardiovascular mortality. CONCLUSIONS: These results indicate that in ESRF patients, the insensitivity of PWV to decreased BP is an independent predictor of mortality and that use of ACE inhibitors has a favorable effect on survival that is independent of BP changes.


Assuntos
Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Doenças da Aorta/tratamento farmacológico , Pressão Sanguínea/efeitos dos fármacos , Falência Renal Crônica/tratamento farmacológico , Fluxo Pulsátil/efeitos dos fármacos , Antagonistas Adrenérgicos beta/uso terapêutico , Aorta/diagnóstico por imagem , Aorta/efeitos dos fármacos , Aorta/fisiopatologia , Doenças da Aorta/complicações , Doenças da Aorta/fisiopatologia , Bloqueadores dos Canais de Cálcio/uso terapêutico , Estudos de Coortes , Feminino , Seguimentos , Humanos , Falência Renal Crônica/complicações , Falência Renal Crônica/fisiopatologia , Masculino , Pessoa de Meia-Idade , Razão de Chances , Valor Preditivo dos Testes , Modelos de Riscos Proporcionais , Estudos Prospectivos , Curva ROC , Taxa de Sobrevida , Resultado do Tratamento , Ultrassonografia
8.
Clin Exp Pharmacol Physiol ; 28(12): 1074-7, 2001 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-11903319

RESUMO

1. In arterial hypertension, aortic wave reflections contribute to determining central systolic and pulse pressures. The present study assessed the central pressure alterations at the level of the common carotid artery following 1 month treatment with perindopril or atenolol and investigated during the 8 h following drug intake. 2. Twenty patients suffering from permanent hypertension were included after a 4 week run-in placebo period in a double-blind, randomized cross-over study comparing the angiotensin-converting enzyme (ACE) inhibitor perindopril with the beta-blocker atenolol during a 4 week treatment period. 3. Before and during the 8 h after drug intake, serial measurements included brachial artery systolic and diastolic blood pressures (SBP and DBP, respectively; mercury sphygmomanometer), carotid artery SBP and pulse pressure (PP; applanation tonometry), aortic pulse wave velocity (Complior; Colson, Les Lilas, France) and arterial wave reflections from the aorta (applanation tonometry; Sphygmocor; PWV Medical, Sydney, NSW, Australia). 4. Both treatments decreased brachial and carotid artery SBP, DBP and PP. Heart rate and pulse wave velocity decreased following atenolol (P < 0.001). Pulse wave velocity was reduced slightly following perindopril (NS). Arterial wave reflections were significantly (P < 0.001) decreased with perindopril in comparison with atenolol, but this effect on wave reflections was not associated with a larger decrease in carotid artery PP. 5. Thus, during chronic treatment, ACE inhibition and selective beta1-adrenoceptor blockade resulted in a similar decrease in brachial and carotid artery PP, but only atenolol reduced heart rate. Aortic pulse wave velocity was reduced with both drugs, but atenolol appeared more effective in improving aortic stiffness. Arterial wave reflections were decreased only following perindopril. 6. Central pulse pressure was improved following 1 month treatment with an ACE inhibitor or beta-adrenoceptor blockade following a decrease in arterial wave reflections with perindopril and a higher decrease in regional aortic stiffness with atenolol.


Assuntos
Antagonistas Adrenérgicos beta/farmacologia , Inibidores da Enzima Conversora de Angiotensina/farmacologia , Atenolol/farmacologia , Artérias Carótidas/efeitos dos fármacos , Hipertensão/fisiopatologia , Perindopril/farmacologia , Antagonistas Adrenérgicos beta/uso terapêutico , Idoso , Inibidores da Enzima Conversora de Angiotensina/uso terapêutico , Atenolol/uso terapêutico , Pressão Sanguínea/efeitos dos fármacos , Pressão Sanguínea/fisiologia , Artéria Braquial/efeitos dos fármacos , Artéria Braquial/fisiopatologia , Artérias Carótidas/fisiopatologia , Estudos Cross-Over , Humanos , Hipertensão/tratamento farmacológico , Pessoa de Meia-Idade , Perindopril/uso terapêutico
10.
Nephrol Dial Transplant ; 15 Suppl 3: 14-8, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-11032352

RESUMO

The amount of oxygen delivered to an organ depends on three factors: blood flow and its distribution; the oxygen-carrying capacity of the blood, i.e. haemoglobin concentration; and oxygen extraction. Non-haemodynamic and haemodynamic mechanisms operate to compensate for anaemia. Non-haemodynamic mechanisms include increased erythropoietin production to stimulate erythropoiesis, and increased oxygen extraction (displacement of the haemoglobin oxygen dissociation curve). This decreased affinity of oxygen for haemoglobin is mediated by increased 2,3-diphosphoglycerate concentrations. Increased cardiac output is the main haemodynamic factor, mediated by lower afterload, increased preload, and positive inotropic and chronotropic effects. Decreased afterload is due to vasodilatation and reduced vascular resistance as a consequence of lower blood viscosity, hypoxia-induced vasodilatation, and enhanced nitric oxide activity. Vasodilatation also involves recruitment of microvessels and, in the case of chronic anaemia, stimulation of angiogenesis. With decreased afterload, the venous return (preload) and left ventricular (LV) filling increase, leading to increased LV end-diastolic volume and maintenance of a high stroke volume and high stroke work. High stroke work is also due to enhanced LV contractility attributed to increased concentrations of catecholamines and non-catecholamine inotropic factors. In addition, heart rate is increased in anaemia, due to hypoxia-stimulated chemoreceptors and increased sympathetic activity. In the long term, these haemodynamic alterations lead to gradual development of cardiac enlargement and LV hypertrophy (LVH). The LVH is eccentric, characterized by increased LV internal dimensions and a normal ratio of wall thickness to cavity diameter, as occurs in other forms of volume overload. When anaemia-related LVH develops in an otherwise 'healthy' humoral environment, the lesions are reversible and the type of LVH is primarily physiological and is not associated with impaired diastolic function. In the absence of underlying cardiovascular disorders, severe anaemia (Haemoglobin concentration < 4-5 g/dl) leads to congestive heart failure. In the presence of heart disease, especially coronary artery disease, anaemia intensifies angina and contributes to a high incidence of cardiovascular complications. In end-stage renal disease (ESRD), LVH is influenced by many other factors, leading to intense interstitial fibrosis, to alterations in diastolic function, and usually to poor reversibility. The chronic increase in cardiac output contributes to arterial remodelling of central elastic arteries such as the aorta and common carotid artery. This remodelling consists principally of arterial enlargement and compensatory arterial intima--media thickening. In ESRD, these geometric changes are accompanied by arterial stiffening. The principal consequences of arterial alterations are increased systolic pressure and high inertia due to higher blood mass in the dilated arterial system. These alterations contribute to the development of LVH and abnormal coronary perfusion.


Assuntos
Anemia/fisiopatologia , Vasos Sanguíneos/fisiopatologia , Coração/fisiopatologia , Anemia/etiologia , Animais , Doenças Cardiovasculares/etiologia , Hemoglobinas/análise , Humanos , Hipertrofia Ventricular Esquerda/etiologia , Falência Renal Crônica/complicações , Falência Renal Crônica/fisiopatologia
11.
Kidney Int Suppl ; 76: S140-7, 2000 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10936811

RESUMO

Cardiovascular disease is the principal cause of morbidity and mortality in dialysis patients. The principal alterations responsible are left ventricular hypertrophy and arterial disease characterized by an enlargement and hypertrophy of arteries and the high prevalence of atheromatous plaques. Left ventricular hypertrophy is the consequence of combined effects of chronic hemodynamic overload and nonhemodynamic biochemical and neurohumoral factors characteristic of uremia. The hemodynamic overload is due to flow and pressure overload. The flow overload is tightly related to hyperkinetic circulation caused by anemia, arteriovenous fistula, or overhydration and is characterized by an enlargement of the left ventricular cavity. The pressure overload in these patients is more tightly related to abnormal geometry and function of large conduit arteries, principally the stiffening of arterial tree. The flow overload is also in large part responsible for remodeling of arterial tree, and as the heart and vessels are a coupled interactive physiological system, cardiac and vascular alterations occur in parallel, being induced to a great extent by the same hemodynamic abnormalities. The principal clinical consequences of left ventricular hypertrophy and arterial alterations are heart failure, ischemic heart disease, and peripheral artery disease. Cardiovascular alterations are only partly reversible, and efforts should be directed toward early prevention.


Assuntos
Hipertrofia Ventricular Esquerda/etiologia , Hipertrofia Ventricular Esquerda/fisiopatologia , Falência Renal Crônica/complicações , Falência Renal Crônica/terapia , Diálise Renal , Humanos
12.
Nephrol Dial Transplant ; 15(7): 1014-21, 2000 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10862640

RESUMO

BACKGROUND: Epidemiological studies have identified aortic stiffness as an independent predictor of cardiovascular mortality in end-stage renal disease (ESRD) patients. In these patients, aortic pulse wave velocity (PWV) was associated with mediacalcosis, but the influence of arterial calcifications on the viscoelastic properties of large arteries was not well characterized. The purpose of the present study was to analyse the influence of arterial calcifications on arterial stiffness in stable haemodialysed patients. METHODS: We studied 120 stable ESRD patients on haemodialysis. All patients underwent B-mode ultrasonography of common carotid artery (CCA), aorta, and femoral arteries to determine CCA distensibility, the elastic incremental modulus (Einc), and the presence of vascular calcifications. All patients underwent measurement of aortic PWV and echocardiogram. The presence of calcifications was analysed semiquantitatively as a score (0 to 4) according to the number of arterial sites with calcifications. RESULTS: Our observations indicate that arterial and aortic stiffness is significantly influenced by the presence and extent of arterial calcifications. The extent of arterial calcifications is in part responsible for increased left ventricular afterload, and is inversely correlated with stroke volume. The influence of calcifications is independent of the role of ageing and blood pressure. Arterial calcifications density increases with age, duration of haemodialysis, the fibrinogen level, and the prescribed dose of calcium-based phosphate binders. CONCLUSIONS: The results of this study showed that the presence of vascular calcifications in ESRD patients was associated with increased stiffness of large capacity, elastic-type arteries, like the aorta and CCA. The extent of arterial calcifications increased with the use of calcium-based phosphate-binders.


Assuntos
Artérias/fisiopatologia , Calcinose/complicações , Calcinose/fisiopatologia , Falência Renal Crônica/complicações , Doenças Vasculares/complicações , Doenças Vasculares/fisiopatologia , Adulto , Idoso , Envelhecimento/fisiologia , Aorta/fisiopatologia , Artérias/diagnóstico por imagem , Ecocardiografia , Elasticidade , Feminino , Fibrinogênio/análise , Humanos , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Pulso Arterial , Diálise Renal
13.
Kidney Int ; 57(3): 1091-9, 2000 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-10720961

RESUMO

BACKGROUND: Cardiovascular complications are the major cause of death in end-stage renal disease (ESRD) patients. These complications are associated with concomitant cardiac and vascular remodeling, including left ventricular (LV) hypertrophy and hypertrophy of arterial walls. The endothelium influences the process of arterial remodeling. ESRD patients are characterized by the development of both cardiovascular remodeling and endothelial dysfunction. METHODS: Common carotid artery (CCA) intima-media thickness (IMT), CCA diameter, CCA distensibility, LV mass, and function were determined in 60 stable ESRD patients on hemodialysis and 34 age-, sex-, and blood pressure (BP)-matched controls, and their relationships with endothelial alterations were estimated by forearm postischemic vasodilation [flow debt repayment (FDR)] measured by venous plethysmography. We also evaluated the relationships between FDR and several cardiovascular risk factors or markers of inflammatory response or endothelial activation, for example, duration of dialysis, BP, smoking habits, cholesterol, parathormone (PTH), serum albumin, plasma fibrinogen, C-reactive protein (CRP), plasma homocysteine, plasminogen activator inhibitor (PAI-1), and von Willebrand factor (vWF). RESULTS: ESRD patients had increased LV mass, CCA diameter and CCA IMT, and had decreased CCA distensibility (P < 0.05). While the postischemic peak flow was comparable in controls and ESRD patients (29.2 +/- 9.1 vs. 27.9 +/- 0.2 mL/100 mL/min), FDR was lower in ESRD patients (116 +/- 31 vs. 88 +/- 32%, P < 0.001) because of the shorter duration of vasodilation (127 +/- 36 vs. 96 +/- 32 s, P < 0.001). The time to complete FDR was longer in ESRD patients (110 +/- 54 vs. 162 +/- 72 s, P < 0.001). ESRD patients had lower high-density lipoprotein cholesterol and serum albumin (P < 0.01) and higher triglycerides, fibrinogen, plasma homocysteine, vWF (P < 0.01), and PAI-1 (P < 0.05). For ESRD patients, significant negative age- and pressure-independent correlations were established between FDR and CCA diameter, duration of dialysis, and PAI-1. FDR was positively correlated with serum albumin. FDR and time to FDR were negatively correlated with CCA IMT and LV mass. CCA distensibility was positively associated with FDR (P < 0.001) and negatively with time to FDR (P < 0.001). The PAI-1 concentration was positively correlated with CCA IMT (P < 0.01) and negatively with CCA distensibility (P < 0.001). CONCLUSIONS: Our data provide the first evidence that cardiac and arterial remodeling in ESRD patients are inversely related to forearm reactive hyperemia. The diminished hyperemic response is due to the shorter duration of hyperemia and is associated with higher concentrations of serum markers of endothelial activation, suggesting that, in ESRD patients, endothelial dysfunction may be a factor influencing cardiovascular changes.


Assuntos
Endotélio Vascular/fisiopatologia , Antebraço/irrigação sanguínea , Isquemia/fisiopatologia , Falência Renal Crônica/fisiopatologia , Vasodilatação , Remodelação Ventricular , Adulto , Idoso , Feminino , Humanos , Hiperemia/etiologia , Isquemia/complicações , Falência Renal Crônica/sangue , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Fluxo Sanguíneo Regional
14.
J Nephrol ; 12(4): 248-55, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10493568

RESUMO

In patients with end-stage renal disease, plasma homocysteine and cardiac mass are both increased and considered independent risk predictors for cardiovascular-specific morbidity and mortality. In order to establish a relationship between these two parameters, we determined cardiac mass and plasma homocysteine in 75 patients with end-stage renal disease undergoing chronic hemodialysis. We observed a statistically significant positive association between plasma homocysteine and cardiac mass index or either of its components. This was observed even after adjustment for age, sex, systolic blood pressure and hematocrit (p = 0.0027). The adjusted odds ratio for left ventricular hypertrophy was 6.6 (95% confidence interval 1.3-32.8) for subjects with the highest versus the lowest plasma homocysteine concentrations. This cross-sectional study is the first to show a statistical link between plasma homocysteine and cardiac structure, independently of mechanical factors. High plasma homocysteine concentrations are associated with an increased adjusted risk of left ventricular hypertrophy in end-stage renal disease patients.


Assuntos
Homocisteína/sangue , Hipertrofia Ventricular Esquerda/etiologia , Falência Renal Crônica/complicações , Pressão Sanguínea , Feminino , Ácido Fólico/sangue , Hematócrito , Humanos , Hipertrofia Ventricular Esquerda/sangue , Hipertrofia Ventricular Esquerda/fisiopatologia , Falência Renal Crônica/sangue , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Razão de Chances , Prognóstico , Diálise Renal , Fatores de Risco , Vitamina B 12/sangue
15.
Am Heart J ; 138(3 Pt 2): 220-4, 1999 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-10467216

RESUMO

An integrated view of the role of arterial blood pressure in cardiovascular physiology should consider both the steady (mean blood pressure) and pulsatile (systolic, diastolic, and pulse pressures) components. This brief overview describes the important factors influencing these components, with emphasis on the consequences of arterial stiffening. In addition to their conduit function, arteries also perform a cushioning function that transforms the pulsatile flow generated by contraction of the left ventricle into steady flow at the periphery. Arterial compliance is a principal determinant of arterial blood pressure and is both pressure dependent and affected by vascular biomechanics. Other important factors that affect the steady and pulsatile components of blood pressure include ventricle performance, peripheral resistance, pulse wave velocity, and the timing of pulse wave reflections. Ageing and hypertension are important factors that contribute to reductions in arterial compliance. Important functional effects of this are that both the amplitude of the arterial pulse wave and pulse wave velocity increase, causing an early return of reflected waves from the periphery to the aorta. This may boost aortic and left ventricular pressures during systole at the expense of diastolic pressure, which is reduced. Studies have shown that stiffening of arteries and the associated increase in systolic and pulse pressures are important cardiovascular risk factors. Patients with an increased risk of cardiovascular events associated with such changes should be identified and receive appropriate therapeutic interventions.


Assuntos
Pressão Sanguínea/fisiologia , Doenças Cardiovasculares/etiologia , Artérias/fisiologia , Humanos , Pulso Arterial , Medição de Risco , Resistência Vascular
16.
Nephrol Dial Transplant ; 14(9): 2178-83, 1999 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-10489228

RESUMO

BACKGROUND: Because recent data demonstrated that the shortened survival and excess cardiovascular death of end-stage renal disease (ESRD) patients are predicted by hyperphosphataemia, we examined the haemodynamic alterations associated with high serum phosphorus levels in ESRD patients on haemodialysis. METHODS: Sixty-six ESRD patients were studied. Patients were separated arbitrarily into two groups, i.e. with predialysis serum phosphate <2 mmol/l ('normal' phosphate) and, serum phosphate >2 mmol/l ('high' phosphate). Cardiac and arterial function and structure were analysed by computer-assisted ultrasonography. RESULTS: Hyperphosphataemic patients were characterized by higher diastolic and mean blood pressures (P<0.05), and higher cardiac index (P<0.001) caused by an increased stroke index (P<0.05) and higher heart rate (P<0.01). The cardiac work index was significantly increased in patients with higher phosphate levels (P<0.01). Hyperphosphataemic patients tended to have a higher common carotid artery diameter (P=0.07), but similar carotid artery intima-media thickness, and lower carotid wall-to-lumen ratio (P<0.05) than patients with 'normal' serum phosphorus. As a result of lower wall-to-lumen ratio in the presence of higher mean blood pressure, the carotid tensile stress was higher in hyperphosphataemic ESRD patients (P<0.05). CONCLUSION: These findings suggest that, in stable ESRD patients, hyperphosphataemia is associated with increased BP, hyperkinetic circulation, increased cardiac work, and high arterial tensile stress. These haemodynamic abnormalities could favour the development of cardiovascular complications and contribute to high cardiovascular morbidity and mortality.


Assuntos
Hemodinâmica , Falência Renal Crônica/sangue , Falência Renal Crônica/fisiopatologia , Fosfatos/sangue , Adulto , Circulação Sanguínea , Pressão Sanguínea , Sistema Cardiovascular/fisiopatologia , Artérias Carótidas/diagnóstico por imagem , Artérias Carótidas/fisiopatologia , Ecocardiografia , Feminino , Coração/fisiopatologia , Humanos , Falência Renal Crônica/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Análise de Regressão , Vasoconstrição
17.
Circulation ; 99(18): 2434-9, 1999 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-10318666

RESUMO

BACKGROUND: Damage to large arteries is a major factor in the high cardiovascular morbidity and mortality of patients with end-stage renal disease (ESRD). Increased arterial stiffness and intima-media thickness, together with increased pulse pressure, are the principal arterial alterations. Whether increased aortic pulse-wave velocity (PWV), a classic marker of increased arterial stiffness, may predict all-cause and/or cardiovascular mortality has never been investigated. METHODS AND RESULTS: A cohort of 241 patients with ESRD undergoing hemodialysis was studied between April 1987 and April 1998. The mean duration of follow-up was 72+/-41 months (mean+/-SD). Mean age at entry was 51.5+/-16.3 years. Seventy-three deaths occurred, including 48 cardiovascular and 25 noncardiovascular fatal events. At entry, together with standard clinical and biochemical analyses, patients underwent echocardiography and aortic PWV measured by Doppler ultrasonography. On the basis of Cox analyses, 2 factors emerged as predictors of all-cause and cardiovascular mortality: age and aortic PWV. Hemoglobin and low diastolic pressure interfered to a smaller extent. After adjustment for all the confounding factors, an OR for PWV >12. 0 versus <9.4 m/s was 5.4 (95% CI, 2.4 to 11.9) for all-cause mortality and 5.9 (95% CI, 2.3 to 15.5) for cardiovascular mortality. For each PWV increase of 1 m/s in our study population, all-cause mortality-adjusted OR was 1.39 (95% CI, 1.19 to 1.62). CONCLUSIONS: These results provide the first direct evidence that in patients with ESRD, increased aortic stiffness determined by measurement of aortic PWV is a strong independent predictor of all-cause and mainly cardiovascular mortality.


Assuntos
Aorta/patologia , Doenças da Aorta/complicações , Arteriosclerose/complicações , Falência Renal Crônica/mortalidade , Adulto , Idoso , Aorta/diagnóstico por imagem , Doenças da Aorta/diagnóstico por imagem , Doenças da Aorta/patologia , Arteriosclerose/diagnóstico por imagem , Arteriosclerose/patologia , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/mortalidade , Causas de Morte , Estudos de Coortes , Comorbidade , Diabetes Mellitus Tipo 1/epidemiologia , Elasticidade , Feminino , Humanos , Hiperlipidemias/epidemiologia , Hipertensão/epidemiologia , Hipertrofia , Hipertrofia Ventricular Esquerda/epidemiologia , Falência Renal Crônica/complicações , Falência Renal Crônica/patologia , Falência Renal Crônica/terapia , Tábuas de Vida , Masculino , Pessoa de Meia-Idade , Prognóstico , Modelos de Riscos Proporcionais , Estudos Prospectivos , Diálise Renal , Fatores de Risco , Fumar/epidemiologia , Análise de Sobrevida , Resultado do Tratamento , Ultrassonografia Doppler
18.
Hypertension ; 32(3): 570-4, 1998 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-9740628

RESUMO

Damage of large arteries is a major contributory factor to the high pulse pressure observed in patients with end-stage renal disease. Whether incremental modulus of elasticity (Einc), a classic marker of arterial stiffness, can predict cardiovascular mortality has never been investigated. A cohort of 79 patients with end-stage renal disease undergoing hemodialysis was studied between September 1995 and January 1998. Mean age at entry was 58+/-15 years. The duration of follow-up was 25+/-7 months, during which 10 cardiovascular and 8 noncardiovascular fatal events occurred. At entry, carotid Einc was calculated from measurements of diameter, thickness (echo-tracking technique), and pulse pressure (tonometry). Based on Cox analyses, 2 dominant factors emerged as predictors of all-cause and cardiovascular mortality: increased Einc and decreased diastolic blood pressure. Lipid abnormalities and the presence of previous cardiovascular events interfered to a smaller extent. After adjustment for confounding variables, the odds ratio for Einc >/=1 kPa-3 was 9.2 (95% confidence interval, 2.4 to 35.0) for all-cause mortality. These results provide the first direct evidence that in patients with end-stage renal disease undergoing hemodialysis, arterial alterations, as determined from carotid Einc, are strong independent predictors of all-cause and cardiovascular mortality.


Assuntos
Doenças Cardiovasculares/mortalidade , Artérias Carótidas/fisiopatologia , Falência Renal Crônica/mortalidade , Idoso , Fatores de Confusão Epidemiológicos , Diabetes Mellitus Tipo 1/complicações , Elasticidade , Feminino , Humanos , Falência Renal Crônica/fisiopatologia , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prognóstico , Estudos Prospectivos , Análise de Regressão , Diálise Renal , Inquéritos e Questionários , Análise de Sobrevida
19.
Arterioscler Thromb Vasc Biol ; 18(4): 535-41, 1998 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-9555858

RESUMO

The incremental elastic modulus of the common carotid and radial arteries is increased in patients with end-stage renal disease (ESRD), independently of blood pressure, wall stress, and the presence of atherosclerotic alterations. Whether biochemical factors may be involved in the arterial changes and related to renal dysfunction remain largely ignored. To assess this question, we measured aortic (carotid-femoral), upper-limb (carotid-radial), and lower-limb (femoral-tibial) pulse wave velocity (PWV) in 74 ESRD patients undergoing hemodialysis in comparison with 57 control subjects similar in age, sex ratio, and mean blood pressure. We evaluated arterial blood pressure by sphygmomanometry, aortic calcifications and cardiac mass by echography, and routine biochemical parameters, total plasma homocysteine, and plasma endothelin levels by standard techniques. In the population of patients with ESRD, on the basis of multiple stepwise regression analysis, aortic PWV was positively and independently correlated with systolic blood pressure (P<.0001), age (P<.0001), prevalence of aortic calcification (P=.0004), and the prevalence of diabetes mellitus (P=.0043). Upper-limb PWV was influenced exclusively by mean blood pressure (P<.0001). Lower-limb PWV was positively and independently correlated with plasma total homocysteine (P=.0004) and plasma endothelin (P=.0187) only. At any vascular site, PWV was not independently correlated with tobacco consumption; plasma levels of cholesterol, triglyceride, fibrinogen, or hemoglobin; body mass index; or the presence of bilateral nephrectomy. Finally, plasma homocysteine was independently correlated with cardiac mass (P=.0022). This study provides evidence that in ESRD patients, the stiffness of the arterial wall and cardiac mass are strongly influenced by biochemical factors related to the kidney alterations and are independent of age and blood pressure level. Increased plasma endothelin and homocysteine may be specifically involved in the vascular damage of lower limbs.


Assuntos
Artérias/fisiopatologia , Homocisteína/sangue , Falência Renal Crônica/fisiopatologia , Adulto , Aorta/fisiopatologia , Doenças da Aorta , Fenômenos Biomecânicos , Calcinose , Artérias Carótidas/fisiopatologia , Ecocardiografia , Elasticidade , Endotelinas/sangue , Feminino , Artéria Femoral/fisiopatologia , Humanos , Falência Renal Crônica/diagnóstico por imagem , Falência Renal Crônica/patologia , Masculino , Pessoa de Meia-Idade , Fluxo Pulsátil , Artéria Radial/fisiopatologia , Artérias da Tíbia/fisiopatologia
20.
J Am Coll Cardiol ; 31(5): 1103-9, 1998 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-9562014

RESUMO

OBJECTIVES: This study sought to present evidence that short stature is a hemodynamic liability, which could explain in part the inverse relation between body height and cardiovascular risk. BACKGROUND: Other explanations for the association of short stature with increased cardiovascular risk include advancing age, reduced pulmonary function, genetic factors, poor childhood nutrition and small-caliber coronary arteries. This study adds another factor-the physiologic effects of reduced body height on the arterial tree, which increase left ventricular work and jeopardize myocardial perfusion. METHODS: Four hundred two subjects were studied: 149 with end-stage renal disease and 253 with normal renal function. Measurements included blood pressure, body height, cardiac cycle length, carotid to femoral artery pulse wave velocity, carotid artery pulse waves (by applanation tonometry) and the arrival time of reflected waves. Calculations included the carotid augmentation index, carotid artery compliance and the diastolic to systolic pressure-time ratio (an index of myocardial supply and demand). RESULTS: On linear and stepwise multiple regression, body height correlated with all variables except mean blood pressure. CONCLUSIONS: The early systolic arrival of reflected waves in short people in this group acts to stiffen the aorta and increase the pulsatile effort of the left ventricle, even at the same mean blood pressures. Short stature also induces a faster heart rate, which increases cardiac minute work and shorten diastole. Stiffening lowers the aortic diastolic pressure and, coupled with a shortened diastole, could adversely influence myocardial supply. Although indirect, this evidence supports a physiologic hypothesis for the body height-cardiovascular risk association.


Assuntos
Estatura , Hemodinâmica , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Artérias/fisiologia , Doenças Cardiovasculares/epidemiologia , Feminino , Frequência Cardíaca , Humanos , Falência Renal Crônica/fisiopatologia , Masculino , Pessoa de Meia-Idade , Fluxo Pulsátil , Análise de Regressão , Fatores de Risco
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