RESUMO
The novel HLA-C*07:975 allele differs from HLA-C*07:40 by a non-synonymous mutation C400G in exon 2.
Assuntos
Medula Óssea , Antígenos HLA-C , Alelos , Éxons/genética , Antígenos HLA-C/genética , Humanos , Doadores de TecidosRESUMO
HLA-C*14:125 allele is identical to HLA-C*14:02:01:01 except for a single nonsynonymous mutation C199T.
Assuntos
Antígenos HLA-C , Alelos , Sequência de Bases , Antígenos HLA-C/genética , Teste de Histocompatibilidade , Humanos , Análise de Sequência de DNARESUMO
HLA-DQB1*05:02:23 differs from DQB1*05:02:01 by a mutation at nucleotide 450.
Assuntos
Alelos , Sequência de Bases , Cadeias beta de HLA-DQ/genética , HumanosRESUMO
The line between vascular dementia (VaD) and Alzheimer's disease (AD) is often blurred. In this study we investigated whether adenosine A2A receptor (A2AR) expression can be used to differentiate between VaD and AD. We evaluated the expression of this receptor in the peripheral blood mononuclear cells of patients with VaD, mild cognitive impairment, AD, and controls. We found statistically significant lower levels of A2AR mRNA in VaD compared to AD subjects. These data suggest that A2AR expression may help in the differential diagnosis between VaD and AD.
