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1.
Zhongguo Dang Dai Er Ke Za Zhi ; 21(12): 1212-1217, 2019 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-31874662

RESUMO

OBJECTIVE: To investigate the influence of genetic and environmental factors on aggressive behavior in twin children, and to provide clues for further exploring the causal relationship between such factors and aggressive behavior. METHODS: A questionnaire was used to investigate aggressive behavior, temperament type and parenting style among 261 twin children aged 4-12.8 years. The Holzinger method and the maximum likelihood method were used to construct a structural equation model for the estimation of heritability. Binary logistic regression analysis, multivariate linear regression analysis and general linear model analysis were used to analyze the association between aggressive behavior and environmental factors in twin children. RESULTS: The heritability of aggressive behavior was 44.4% in twin children and the score of aggressive behavior showed moderate heritability (60.9% in boys and 65.6% in girls). The multivariate analysis showed that the score of aggressive behavior in twin children was affected by the mother's emotional warmth/understanding, the mother's punishment/severity and the father's overprotection (P<0.05). There was an interaction between the mother's emotional warmth/understanding and the father's overprotection (P<0.05). CONCLUSIONS: Both genetic and environmental factors have influence on children's aggressive behavior, and parenting style is the main environmental factor affecting the aggressive behavior of twin children.


Assuntos
Comportamento Infantil , Criança , Pré-Escolar , Pai , Feminino , Humanos , Masculino , Mães , Poder Familiar , Inquéritos e Questionários , Gêmeos
2.
Zhongguo Dang Dai Er Ke Za Zhi ; 18(6): 501-5, 2016 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-27324537

RESUMO

OBJECTIVE: To study the effects of rs4274224 polymorphisms in the DRD2 gene, family factors and their interaction on the regularity in school-age children. METHODS: The rs4274224 polymorphisms were genotyped using Sequenom Mass Array. The regularity was assessed based on the Middle Childhood Temperament Questionnaire (MCTQ). The parental rearing pattern was assessed with Egna Minnen av Bardnodnauppforstran (EMBU). The family function was assessed using Family Cohesion and Adaptability Scale (FACES II-CV). RESULTS: The regularity score in children with AA genotype of rs4274224 in the DRD2 gene was significantly lower than in those with GA/GG genotype (2.9±0.6 vs 3.1±0.7; P<0.05). The results of multiple regression analysis showed that the regularity was related to child gender, father's education level and family adaptability. The results of logistic regression analysis showed that the main factors influencing the regularity were family adaptability and its interaction with rs4274224 polymorphisms. The regularity was better in children with high family adaptability than in those with low family adaptability (OR=0.112, P<0.01). The children with AA genotype and low family adaptability were tend to be associated with low regularity (OR=21.554, P<0.01). CONCLUSIONS: The regularity based the temperament for school-age children might be influenced by family adaptability and its interaction with rs4274224 polymorphisms.


Assuntos
Polimorfismo Genético , Receptores de Dopamina D2/genética , Temperamento , Criança , Feminino , Genótipo , Humanos , Masculino , Inquéritos e Questionários
3.
Zhongguo Dang Dai Er Ke Za Zhi ; 17(3): 270-4, 2015 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-25815499

RESUMO

OBJECTIVE: To study the association between rs1079595 polymorphisms in the DRD2 gene and the distractibility in school-age children. METHODS: The genotyping at rs1079595 was performed and the distractibility was measured based on the temperament questionnaire in 120 8-12 years old school-age children in order to analyze the effects of the rs1079595 polymorphism and its interaction with the gender, age and delivery mode on the distractibility. RESULTS: There was an association between the distractibility and rs1079595 polymorphisms. The distractibility score in children with GG/GT genotypes was significantly higher than in children with the TT genotype (4.3 ± 0.6 vs 4.0 ± 0.7; P<0.05). The interaction between rs1079595 polymorphisms and the delivery mode produced an effect on the distractibility. The normal delivery children with T alleles were associated with a low distractibility (OR=0.037, P<0.01). CONCLUSIONS: The distractibility based the temperament might be influenced by the rs1079595 polymorphism and its interaction with the delivery mode in school-age children.


Assuntos
Polimorfismo Genético , Receptores de Dopamina D2/genética , Temperamento , Criança , Parto Obstétrico , Feminino , Genótipo , Humanos , Modelos Logísticos , Masculino
4.
J Int Med Res ; 42(1): 120-9, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24345824

RESUMO

OBJECTIVE: A large proportion of preschoolers have been left behind due to parental migration in rural China. We conducted a preliminary cross-sectional survey to investigate the mental health of these left-behind preschool-aged children (LBPC) and associated risk factors. METHODS: A total of 750 LBPC, comprising 217 and 433 children left behind as a result of migration of either or both parents, respectively, and 100 controls were enrolled from two counties in Anhui province, China. Their caregivers completed questionnaires on demographics, the Family Support Scale, the Parenting Self-efficacy Scale and the Preschool-aged Child Mental Health Scale. RESULTS: There were no significant differences in mental outcomes among the three groups. However, male LBPC who were younger, fostered by caregivers with lower levels of life satisfaction and parenting efficacy, and came from poorer families with less social support, experienced more mental health problems than other children. CONCLUSIONS: LBPC did not have worse mental well-being than their control counterparts, but some subpopulations were at potential risk of mental health problems compared with other LBPC. More research on other underlying factors and strategies to prevent the development of psychopathology is urgently needed.


Assuntos
Criança Abandonada , Saúde Mental , População Rural , Cuidadores , Estudos de Casos e Controles , Pré-Escolar , China/epidemiologia , Estudos Transversais , Família , Feminino , Humanos , Masculino , Satisfação Pessoal , Fatores de Risco
5.
Zhonghua Yu Fang Yi Xue Za Zhi ; 47(10): 900-4, 2013 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-24378128

RESUMO

OBJECTIVES: To establish a method for screening neonatal tetanus (NT) in high risk areas in China using multi-sources data. METHODS: We adopted six NT-related indicators from National Notifiable Disease Report System (NNDRS) and National Maternal and Child Health Annual Report System, to calculate weighted high-risk score at prefecture level in 2010 and 2011. And we selected the top 30 high risk cities, and compared the scores with the actual NT incidence ranking and WHO scoring. RESULTS: The highest areas distributed in the Southwest of China with poor and minority population, and the Southeast part with high density of migrants. In the leading 30 prefectures with high score between the methods of weighted high-risk scoring and reported NT incidence ranking, there were 8 different. In comparison of the results of the methods of weighed high-risk scoring and WHO scoring, 276 prefectures in 340 distributed were divided into the same ranking groups, with Kappa coefficient 0.56 (P < 0.01). The Chi-Square association coefficient was 0.74 (P < 0.01), which showed a high correlation. But there were 10 different prefectures in the leading 36 prefectures between the two methods. CONCLUSION: The weighted scoring method included several possible factors influencing NT incidence and took their weights into consideration. Thereby, compared with WHO scoring method, this method could be more appropriate for the reality in China.


Assuntos
Triagem Neonatal , Tétano/epidemiologia , Tétano/prevenção & controle , China/epidemiologia , Humanos , Recém-Nascido
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