Predictive value of neutrophil to lymphocyte ratio on acute kidney injury after on-pump coronary artery bypass: a retrospective, single-center study.

OBJECTIVE: To investigate the predictive value of preoperative neutrophil to lymphocyte ratio (NLR) on acute kidney injury (AKI) after on-pump coronary artery bypass (ONCAB). METHODS: Patients who underwent elective ONCAB for coronary heart disease were included. NLR was calculated according to the results of preoperative routine blood test, patients were divided into non-AKI and AKI groups, and the differences in clinical baseline data between the two groups were compared. RESULTS: A total of 154 patients were included in this study, including 57 (37%) with postoperative AKI and 97 (63%) without AKI. Compared with the patients in non-AKI group, those in AKI group had higher NLR (2.63 (1.83, 3.505) vs. 2.06 (1.7, 2.56), p = 0.002), higher serum creatinine (78 (67, 98.5) vs. 70.9 ± 16.8 umol/L, p < 0.001), longer cardiopulmonary bypass time, and longer aortic cross clamp time. After dividing patient into tertiles based on NLR, those with higher NLR had higher risk of postoperative AKI than those with lower NLR (30% vs. 25% vs. 55.8%, p for trend = 0.003). Patients in Tertile2 and Tertile3 had higher NLR compared to those in Tertile1 (p < 0.05); multivariate logistic regression analysis showed patients with elevated preoperative NLR and blood creatinine had higher risk of postoperative AKI. ROC curve showed that patients' preoperative NLR combined with blood creatinine had better predictive value for postoperative AKI. CONCLUSION: Elevated preoperative NLR is associated with AKI after ONCAB, and had prognostic utility independent of other recognized risk factors.

Study on the changes of insulin ,C peptide and blood glucose levels in diabetic with liver damage patients and its clinical significance / 国际检验医学杂志

Objective To explore the early diagnosis value of insulin ,C peptide ,blood glucose detection in diabetic patients with liver damage .Methods A total of 120 cases of diabetic patients were selected from January 2014 to January 2016 ,all of them were divided into 53 cases of diabetes mellitus complicated with liver injury group (Study Group 1) and 67 cases of diabetes with normal liver function group (Study Group 2) ,and 50 cases healthy people in the same period were selected as the control group .fasting blood glucose (FBG) ,2 Hours Postprandial Blood Glucose (2hPG) ,Glycosylated Hemoglobin (HbA1c) ,fasting insulin (FINS ) ,2 h postprandial fasting insulin (P2INS) ,homeostasis model assessment-insulin resistance index (HOMA-IR) ,c-peptide (CP) and (2 hour postprandial fasting C peptide) P2CP levels of every group were detected ,and the correlation with indexes and liver damage was analyzed .Results FBG ,2hPG ,HbA1c ,FINS ,P2INS ,HOMA-IR ,CP ,P2CP levels in Study group 1 and Study Group 2 were significantly higher than those in the control group (P<0 .05) ,and each index level in Study group 1 was significantly higher than that in study Group 2(P<0 .05);correlation analysis showed that the diabetes mellitus combined with liver damage was positively correlated with FBG ,2hPG ,HbA1c ,FINS ,P2INS ,CP ,P2CP levels (r=0 .274 ,0 .190 ,0 .220 ,0 .230 ,0 .195 ,0 .083 ,0 .289 ,0 .724 re-spectively ,P<0 .05) .Conclusion Pancreatic islet function and blood glucose metabolism play an important role in diabetic patients with liver damage ,and three indexes combined detection can be used as early diagnosis of diabetes mellitus combined with liver damage .

The Effects of Iontophoretic Injections of Salvia miltiorrhiza on the Maturation of the Arteriovenous Fistula: A Randomized, Controlled Trial.

Context • For patients undergoing hemodialysis, the native arteriovenous fistula (AVF) is the primary approach to vascular access (VA). VA failure is the main cause of morbidity and mortality in hemodialysis patients. It has been reported in recent studies that the primary failure rate can be as high as 50%. Objective • The study investigated the effects of iontophoretic administration of Salvia miltiorrhiza (SM) on the maturation of the AVF. Design • The study was a randomized, controlled trial. Setting • The study occurred in Guangdong Provincial Hospital of Traditional Chinese Medicine (Guangzhou, China). Participants • Participants were 40 patients with chronic kidney disease at stage 4 or 5. Intervention • Participants were randomly assigned to one of 2 groups (n = 20 each) after they had received an AVF operation. Patients in the control group were given routine care, and patients in the intervention group were given routine nursing in combination with an iontophoretic SM injection on a targeted area of the fistula after surgery. Outcome Measures • The blood flow of the AVF, the diameter of the artery vein shunt, and the thickness of the AVF from the vascular wall to the skin were observed. Results • The maturation rates of the AVFs after 1 mo were 50% and 85% in the control group and the intervention group, respectively. A significant difference existed between the 2 groups (P < .05). The results of the surgery were significantly different for the control and intervention groups, with the blood flows of the AVF being 1182.05 ± 547.10 mL/min and 705.55 ± 278.63 mL/min (P < .05), respectively, and the diameters of the artery vein shunts being 4.51 ± 1.47 mm and 3.54 ± 0.67 mm (P < .05), respectively, after treatment. Conclusions • Iontophoretically mediated, transdermal delivery of an SM injection to a targeted area of the AVF can significantly shorten the time to maturity of the fistulae.

Screening analysis of deafness gene in neonatus / 国际检验医学杂志

Objective To analyze the molecular epidemiology characteristic of neonatal deafness susceptibility genes .Methods Hearing screening and deafness susceptibility genes screening were performed in 1 674 cases of newborn to analyze the epidemiolog‐ical characteristics .Results Among 1 674 cases of neonatus ,37 cases were with deafness susceptibility gene abnormalities ,inclu‐ding 2 cases of 176 del 16 mutations ,5 cases of 299 del AT heterozygous mutation ,16 cases of 235 del C mutation ,9 cases of IVS7‐2A>G heterozygous mutations ,1 case of 2168A> G mutation ,2 cases of 538C> T heterozygous mutation ,2 cases of 1494C> T mutation ,and the positive rate was 2 .21% .Conclusion Hearing screening combined with deafness susceptibility gene screening could detect possible hearing loss children from molecular level ,providing favorable reference for the early detection ,predict and in‐terventions .

Clinical significance of serum levels of procalcitonin,C-reactive protein and white blood cell count in children with infectious diseases / 国际检验医学杂志

Objective To explore the diagnostic value of serum procalcitonin ,C‐reactive protein and white blood cell count in children with different diseases .Methods Retrospective analysis 94 cases of pathogenic infectious children from June 2013 to May 2014 in our hospital ,according to the results of pathogen detection was divided into bacterial infection 36 cases ,mycoplasma infec‐tion group 28 cases ,30 cases of viral infection ,detection and analysis serum PCT ,CRP and WBC levels .Results Bacterial infection group serum PCT ,CRP and WBC were (2 .41 ± 0 .94)ng/mL ,(47 .91 ± 18 .26)mg/L and (13 .18 ± 6 .03) × 109/L ,significantly higher than the mycoplasma infection and viral infection group (F=133 .4 ,F=60 .1 ,F=8 .5 ,P<0 .05);diagnosis of bacterial in‐fections ,PCT sensitivity and specificity were 92 .11% and 91 .05% ,positive and negative predictive value of 89 .84 % and 94 .01%were significantly higher than CPR and WBC ,Mycoplasma infection as the control group ,PCT ,CRP and WBC in the diagnosis of bacterial infections ,the area of under the ROC curves were 0 .816 ,0 .728 and 0 .614 ,respectively .Conclusion Serum PCT for the i‐dentification of bacterial infections has a high diagnostic value ,worth generalizing and applying .

Analysis on reliability and validity of the Pittsburgh sleep quality index / 重庆医学

Objective To assess the reliability and validity of the Pittsburgh sleep quality index (PSQI) .Methods The cross-sectional survey was conducted in the outpatient department of this hospital .544 insomnia and non-insomnia voluntary participants (18-65 years old) from July to October 2011 were assessed with PSQI and the insomnia severity index (ISI) ,which were randomly delivered to them .Results The test-retest reliability of PSQI was 0 .994 .The split-half reliability coefficient of PSQI was 0 .824 . The overall Cronbach′s alpha coefficient was 0 .845 .The confirmatory factor analysis showed that the fitting indicators for the χ2/df ,root mean square error of approximation(RMSEA) ,non-normed fit index(NNFI) ,comparative fit index(CFI) and goodness-of-fit index(GFI) were 4 .83 ,0 .09 ,0 .96 ,0 .98 and 0 .97 respectively .The correlation coefficient between the PSQI and ISI was 0 .842 . The correlations coefficients between PSQI with the questionnaire type ,interview date and interview department were -0 .046 , 0 .276 and -0 .331 .Grouping by individuals with or without insomnia ,the area under the receiver operator characteristic curve (ROC) for PSQI was 0 .944(95% CI:0 .925-0 .963) .Conclusion PSQI has good reliability and validity ,and could be used for the sleep quality comprehensive evaluation in the patients with insomnia .

Influence on Establishment and Implementation of Individual Healthy Diets on Patients with Early Diabetic Nephropathy / 世界科学技术-中医药现代化

This study was aimed to explore the efficacy of establishing and implementing individual healthy di-ets on patients with early diabetic nephropathy ( DN ) . A total of 120 patients with early DN of our hospital were randomly divided into two groups , which were the experimental group and the control group . There were 60 cases in each group . All patients received routine treatment . The fasting blood glucose and 24-hour uri-nary protein were measured pre-treatment , 2-week , 2-month , and 6-month after treatment . Patients in the experimental group were required to receive individual healthy diet therapy as well as routine treatment . The fasting blood glucose of both groups was compared in each stage . The fasting blood glucose of the experimental group was lower than that of the control group after 2-week treatment . After 6-month treatment , the fasting blood glucose of the experimental group was lower than that of pre-treatment . However , there was no obvious difference in the control group compared to that of pre-treatment . There were significant differences on the number of cases with fasting blood glucose below the level of 7.0 mmol/L in different stages of both groups. The 24-hour urinary protein of both groups was also compared in each stage . After 2-week treatment , there was no distinct difference on the 24-hour urinary protein in each stage of both groups . However , after 6-month treatment , the urinary protein of the experimental group , compared to pre-treatment , indicated striking difference , while the control group did not show any difference . It was concluded that individual healthy diet has a significant efficacy in the treatment of early DN , especially in reducing and controlling fasting blood glucose. After carrying out the treatment for 6 months, healthy diet also takes on distinct effects in cutting down 24-hour urinary protein and keeping the glycosylated hemoglobin below 6 . 5%.

Clinical Observation on 120 Cases of Hypertension Treated with Deng Tietao's Foot-bath Recipe / 中医杂志

Objective:To observe clinical therapeutic effect of Deng Tietao's Yuzu Recipe on hypertension.Methods:240 cases of inpatients of hypertension were randomly divided into a trial group and a control group,establishing database,and descriptive analysis,t-test,x~2 test and rank test methods were adopted.Results:(1)There was significant difference between the two groups in the decreasing effect of blood pressure(P