RESUMO
Stenotrophomonas maltophilia is an important emerging pathogen causing a variety of infections in severely ill patients. This microorganism is inherently resistant to many antibiotics, and only a few therapeutic options are available. The principal aim of this study was to assess the in vitro activity of new quinolones against this pathogen. Three hundred and twenty-six single clinical isolates were tested in this study. The MIC(90) was 16 mg/L for ciprofloxacin, 8 mg/L for levofloxacin and gatifloxacin, 4 mg/L for trovafloxacin, moxifloxacin and sparfloxacin and 2 mg/L for clinafloxacin. At a 2 mg/L concentration, a C(max) lung:MIC ratio of >/=10 can be reached for 95%, 84.3%, 83.1% and 81.5% of isolates, respectively, for clinafloxacin, trovafloxacin, moxifloxacin and sparfloxacin (P < 0. 001 compared with levofloxacin and ciprofloxacin). In spite of the rare but serious adverse events associated with the new-generation quinolones, these agents may become very useful in the treatment of certain severe or life-threatening infectious conditions due to S. maltophilia, notably lower respiratory tract infections.
Assuntos
Antibacterianos/farmacologia , Infecções por Bactérias Gram-Negativas/microbiologia , Stenotrophomonas maltophilia/efeitos dos fármacos , 4-Quinolonas , Resistência Microbiana a Medicamentos , Humanos , Testes de Sensibilidade Microbiana , Combinação Trimetoprima e Sulfametoxazol/farmacologiaRESUMO
In order to address the personal and professional characteristics as well as the physical, mental, and reproductive health of women physicians, a survey was mailed to a random sample of 3,000 women and men physicians in the province of Québec, Canada. The data obtained from women physicians were compared with those from men physicians and with available data on a comparable subgroup of professional women. The sociodemographic and health data highlight the physical and mental health status of women physicians. These data, which provide a global picture of Québec women physicians, indicate that in spite of the challenges, they seem to reconcile their professional and parental activities without major repercussions on their physical and mental health.
