Assuntos
Aflatoxinas/toxicidade , Transtornos da Coagulação Sanguínea/induzido quimicamente , Síndromes de Imunodeficiência/induzido quimicamente , Mutagênicos , Efeitos Tardios da Exposição Pré-Natal , Aflatoxina B1 , Animais , Aberrações Cromossômicas , Feminino , Macaca mulatta , Masculino , GravidezRESUMO
A mutagenic effect of aflatoxin B1 (AFB1) was studied in somatic cells of primates. It is shown that AFB1 elevates the chromosome aberration frequency in bone marrow cells of two monkey species: Macaca mulatta and Papio hamadryas. Genome mutations were found in these experimental primates simultaneously with chromosome aberrations. The AFB1-induced chromosome aberrations were revealed at least during two years of the study. The fact of the chromosome aberration frequency increase was established in Macaca babies born from females who received AFB1 in pregnancy.
Assuntos
Aflatoxinas/farmacologia , Medula Óssea/efeitos dos fármacos , Aberrações Cromossômicas , Mutagênicos/farmacologia , Aflatoxina B1 , Animais , Medula Óssea/ultraestrutura , Diploide , Feminino , Macaca mulatta , Masculino , Papio , Poliploidia , Fatores de TempoRESUMO
A mutagenic effect of aflatoxin B1 (AFB1) in somatic cells of primates is investigated. It is shown that AFB1 elevated the frequency of chromosome aberrations in the bone marrow of two species of monkeys: Macaca mulatta and Papio hamadryas. Beside chromosome aberrations, genome mutations were found in these experimental primates. AFB1-induced chromosome aberrations were constantly revealed during two years of study. Increase in the frequency of chromosome aberrations could be demonstrated in Macaca babies born from females that had received AFB1 at the final stage of pregnancy.
Assuntos
Aflatoxinas/toxicidade , Medula Óssea/patologia , Carcinógenos/toxicidade , Aberrações Cromossômicas , Aflatoxina B1 , Animais , Medula Óssea/efeitos dos fármacos , Cariotipagem , Macaca mulatta , Mutação , Papio , Especificidade da EspécieRESUMO
The Carr-Zilber strain of Rous sarcoma virus is highly oncogenic for adult monkeys of the species Macaca mulata. In the present study the authors examined some characteristics of tumor growth, when the tumor either regressed or progressed until it killed its host. The kinetics of antibody formation to antigens coded as CZ-RSV was followed in animals with a different course of tumor disease. The sera of animals under test contained virus-neutralizing antibodies in addition to gs antibodies.
Assuntos
Sarcoma Aviário/fisiopatologia , Animais , Anticorpos Antineoplásicos/análise , Anticorpos Antivirais/análise , Vírus do Sarcoma Aviário/imunologia , Feminino , Genes Virais , Macaca mulatta , Masculino , Sarcoma Aviário/imunologia , Fatores de TempoRESUMO
The Carr-Zilber strain of Rous sarcoma virus is highly oncogenic for adult monkeys of the species Macaca mulata. In the present study, we examined some characteristics of tumor growth when the tumor either regressed or progressed until it killed its host. We followed the kinetics of antibody formation to antigens coded by CZ-RSV in animals with a different course of tumor disease. The sera of animals tested contained virus-neutralizing antibodies, in addition to gs antibodies. The results are discussed with regard to the possible virus-productive type of interaction between RSV and the monkey cell.
