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Acta Physiol Hung ; 97(4): 401-7, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21138816

RESUMO

Artificial sweeteners are widely used all over the world. They may assist in weight management, prevention of dental caries, control of blood glucose of diabetics, and also can be used to replace sugar in foods. In the animal experimentation mice were given oral doses of water solutions of table top artificial sweeteners (saccharin, cyclamate based, acesulfame-K based, and aspartame) the amount of maximum Acceptable Daily Intake (ADI) ad libitum. The controls received only tap water with the same drinking conditions as the treated groups. The mice were fed chow ad libitum.We measured food intake and body weight once a week, water and solutions of artificial sweeteners intake twice a week. The data were analysed by statistical methods (T-probe, regression analysis).Consumption of sweeteners resulted in significantly increased body weight; however, the food intake did not change.These results question the effect of non-caloric artificial sweeteners on weight-maintenance or body weight decrease.


Assuntos
Comportamento Animal/efeitos dos fármacos , Peso Corporal/efeitos dos fármacos , Ingestão de Líquidos/efeitos dos fármacos , Ingestão de Alimentos/efeitos dos fármacos , Edulcorantes/farmacologia , Animais , Aspartame/farmacologia , Ciclamatos/farmacologia , Feminino , Masculino , Camundongos , Camundongos Endogâmicos CBA , Sacarina/farmacologia , Tiazinas/farmacologia , Fatores de Tempo
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