[Effects of cranial radiotherapy on growth and hypothalamo-hypophyseal function]. / Efectos del empleo de la radioterapia craneal sobre el crecimiento y función hipotálamo-hipofisaria.

Aiming at evaluating the possible adverse effects of the use of radiotherapy on the CNS in children, we studied fourteen patients in whom it was used: seven as part of the conventional prophylaxis we use in malignant lymphoproliferative processes (group I) and the remaining seven as a treatment for primary cerebral tumors (group II). We evaluated growth during periods ranging from 1.5 to 11 years, and also hypothalamic-pituitary function by RIA. We comment on the results and confirm the endocrine alterations, especially the deficit of growth hormone.

[Effects of the use of cranial radiotherapy. Findings obtained by computerized axial tomography and intellectual function tests]. / Efectos del empleo de la radioterapia craneal. Hallazgos en la tomografía axial computerizada y función intelectual.

Authors report their brain computerized axial tomography findings (CAT) and intellectual performance, in fourteen children treated with cranial radiotherapy either as part of conventional prophylaxis with intrathecal methotrexate use in malignant lymphoproliferative processes or as treatment for a primitive cerebral tumor. They comment on myelinating leukoencephalopathy and neuropsychologic sequelae that can appear.