[Stratification of risk factors of progressing of acute respiratory infection in children].

The work purpose is the complex estimation of endogenous intoxication (change of optical density of plasma and erythrocytes), depressions of tissue hypoxia and functions of protective system, clinical and laboratory stratification of the risks-factors promoting progressing of disease and complication of pneumonia. There was carried cross-section study. The study included 36 patients from 1 to 7 years with an acute respiratory infection. The control group was made up of 19 healthy children. The comparative analysis of results of the specified factors and laboratory research set as the purpose to reveal the predictable negative risk factors. Evaluation of the quantitative findings of risks-factors was carried out in 95 % taking into account the confidence interval (CI). For the acute respiratory infection complicated with pneumonia, was determined strongly marked toxemia, and also high activity of antioxidant systems (SOD and catalase) and lysosomal enzymes (catepsin, RNA) was noted. The prognosis of the authentic risks-factors of acute respiratory disease was defined with following indicators: age of the child - before three years; hereditary background with a respiratory system pathology; the tobacco use in a family; low level of knowledge of parents; incomplete treatment; change of optical density of plasma and erythrocytes; fall (reduction) of redox-potential of the system of energy maintenance. We developed predictable model on probability of expected complications of respiratory system and groups of low, average and high risk were allocated.

[Role of morpho-functional changes of blood lymphocytes in pathogenesis of psoriasis and the possibilities for their correction].

It is well known, that the cells of T-lymphoid population including Th2 lymphocytes of the skin, as well as circulating cells has the great importance in the pathogenesis of psoriasis. The goal of given research was to define the role of morpho-functional changes in blood lymphocytes in the pathogenesis of psoriasis and the possibilities for their correction. On the background of our investigation it could be concluded that in the case of the vulgar form of psoriasis in peripheral blood lymphocytes the intensified expression of p-53 preapoptotic protein results from affecting of NO induced damage of DNA molecule, in terms of intensification of oxidative stress in organism, which contributes to the activation of apoptosis of peripheral blood lymphocytes and is presented as one of the reasons which can cause the degradation of lymphocyte-induced apoptosis of keratinocytes. After the course of balneal therapy in "Nunisi" the decrease in expression of p-53 lymphocytes has been observed, big lymphocytes are predominant ones, with indications of synthetic activity of ultrastructure. This effect is conditioned by antioxidative characteristics of waters of "Nunisi" which assists to decreasing of the oxidative stress in patient's organism and recovers redox state of nitrogen oxide; it contributes to the intensification of keratinocytes apoptosis and to the prompt clearance of psoriatic lesion foci in epidermis.