1.
Anal Bioanal Chem
; 374(1): 57-63, 2002 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12207242
RESUMO
MALDI-TOF mass spectrometry has been used to characterize solid-supported oligonucleotides containing natural and non-natural and non-nucleoside moieties and a variety of internucleosidic linkages including phosphate and phosphite triesters and H-phosphonate diesters. This technique was used to follow the reactions involved in oligonucleotide synthesis; this enabled direct control of the elongation and optimization of the coupling process.
Assuntos
Oligodesoxirribonucleotídeos/química , Oligodesoxirribonucleotídeos/síntese química , Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos , Sequência de Bases , Análise de Sequência com Séries de Oligonucleotídeos
2.
Bioorg Med Chem Lett
; 11(21): 2813-6, 2001 Nov 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11597406
RESUMO
A short TCCT Me-SATE prooligonucleotide was successfully synthesized using 2-(tert-butyldiphenyloxymethyl) benzoyl protecting group, after its removal by means of trimethylsilyl chloride and water.
