1.
Bioorg Med Chem Lett
; 23(21): 6025-8, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24035339
RESUMO
The synthesis of an isosteric analog of the natural product and HDAC inhibitor largazole is described. The sulfur atom in the thizaole ring of the natural product has been replaced with an oxygen atom, constituting an oxazole ring. The biochemical activity and cytotoxicity of this species is described.