Expresión de p53 en 63 carcinomas gástricos consecutivos / p53 expresssion in 63 consecutive gastric carcinomas

Planteamiento: La p53 es una proteína implicada de manera importante en el desarrollo de muchas neoplasias, interviniendo en el crecimiento celular, aunque su verdadera función aún tiene que ser más investigada. La idea de este estudio fue valorar la expresión de p53 como marcador de progresión tumoral y factor pronóstico en el carcinoma gástrico. Materiales y métodos: Hemos determinado la expresión inmunohistoquímica de p53 (clon D07) en 63 carcinomas gástricos consecutivos (62 biopsias endoscópicas y 37 especímenes de resección), relacionándolo con los parámetros histológicos y la evolución. Resultados: El 70 por ciento de las piezas quirúrgicas (26/37) y el 64 por ciento de las biopsias endoscópicas (40/62) muestran manifiesta o intensa expresión de p53, sin relación claramente significativa con el tipo histológico o el grado de diferenciación. Conclusiones: Los carcinomas gástricos frecuentemente expresan p53, siendo independiente de otros parámetros (tipo histológico, infiltración, grado de diferenciación), y no constituyen una variable pronóstica independiente. Existe una buena correlación entre la expresión de p53 en las biopsias endoscópicas y las piezas quirúrgicas. (AU)

[Results of ambulatory major surgery in urology, within an integrated unit]. / Realización de cirugía mayor ambulatoria en urología, dentro de una unidad integrada.

OBJECTIVE: To contribute our experience in the performance of ambulatory major surgery, through the creation of an integrated unit. Such units take advantage of existing resources both in terms of space and materials, as well as personnel, without the need to open separate ambulatory major surgery units that would involve greater resources expenditure. MATERIAL AND METHODS: 48 patients undergoing ambulatory major urology surgery were analyzed. The patients were admitted the same morning of the procedure and then, after leaving the operating theatre, they were moved to the reanimation room and later to the urology ward, where they were evaluated by the urologist on duty and discharged. A few days later the patients returned to the outpatient's clinic for re-evaluation. RESULTS: 48 patients underwent surgery, 44 male and 4 female. Mean age of patients was 34 (3-86) years. The procedures most frequently performed were: hydrocelectomy, vaginal peritoneum duct closure, orchiopexy, ureterorenoscopy due to ureteral lithiasis, internal urethrotomy, varicocelectomy, vesical tumor resection and circumcision in children. Only in two cases, hospital stay was longer than 12 hours and there was only one re-admission. CONCLUSIONS: Ambulatory major surgery integrated units may allow to perform this type of surgery in small units, with little resources and with a volume of patients not sufficient to create an independent unit.

[Reduction of hospital stay, because of the early removal of the bladder catheter in transurethral resection of the prostate]. / Reducción de la estancia hospitalaria, por la retirada precoz de sonda vesical en la resección transuretral de próstata.

OBJECTIVE: To analyze the effects of removal of the bladder catheter 48 hours following transurethral resection of the prostate for benign prostatic hyperplasia in relation to the length of hospital stay and the incidence of important postoperative complications. METHODS: A study was conducted on 117 patients who had undergone TURP at our hospital over a period of one year. They were divided into two groups: group I comprised 55 patients in whom the bladder catheter had been systematically removed 48 hours following the procedure and had been discharged from hospital once they had attained a satisfactory micturition; group II comprised 62 patients in whom the bladder catheter was removed following conventional practice. RESULTS: The mean length of hospital stay for the early catheter removal group was 2.02 days versus 3.85 days for group II. The postoperative complication rate was similar for both groups. CONCLUSIONS: Early removal of the bladder catheter following TURP does not increase the complication rate. It shortens the length of hospital stay and reduces the cost of the procedure.