Relação de distúrbios temporomandibulares e alterações do padrão de sono na síndrome da fibromialgia ­ revisão da literatura / Relationship of temporomandibular disorders and sleep patterns in fibromyalgia syndrome

A fibromialgia é uma síndrome reumática caracterizada por quadros dolorosos intensos. A presença da dor muitas vezes chega a causar incapacidade e indisposição, mesmo para realização de atividades rotineiras, bem como parece afetar o sono em grande parte dos pacientes. Acredita-se que a perpetuação de alterações no padrão de sono crie uma situação cíclica que intensifica os quadros dolorosos e a fadiga. Os distúrbios temporomandibulares (DTM) que são caracterizados por quadros de dor também vêm sendo relacionados com alterações no sono. Essas duas condições, apesar de distintas, parecem coexistir em um grande número de portadores de fibromialgia, levando-se a pesquisas que visam buscar a influência dessa relação como causa e efeito dentro deste grupo de pacientes. Neste contexto, este trabalho teve o objetivo de recolher informações dentro da literatura sobre essas duas condições, sua influência nas alterações do sono, bem como reunir estudos que busquem esclarecer a relação existente entre as duas condições. Para isto foram reunidos trabalhos publicados na base de dados PubMed, LILACSeMEDLINEutilizando-se os termos fibromialgia, DTM e sono, nos idiomas inglês e português. Os trabalhos apontam que há uma prevalência alta entre mulheres e que os portadores de fibromialgia apresentam alterações específicas no padrão de sono, bem como há uma importante correlação desta condição com os distúrbios temporomandibulares (AU).

Fibromyalgia syndrome is characterized by severe painful conditions. The presence of pain can result in some disability and even unwillingness to perform routine activities, and seems to affect sleep in most patients. It is believed that the changes in sleep pattern creates a cyclic condition and can increase fatigue painful conditions. The temporomandibular disorder (TMD) is characterized by pain frameworks have also been related to changes in sleep. These two conditions, while distinct, seem to coexist in a large number of patients with fibromyalgia, leading several researchs concerning the influence of this relationship within this group of patients. Therefore, this work aimed to collect information in the literature on these two conditions, its influence on sleep disorders as well as gathering studies that seek to clarify the relationship between these two conditions. For this were selected studies published in PubMed, LILACS, and MEDLINE using the terms fibromyalgia, TMD and sleep, in English and Portuguese. The studies indicate that there is a high prevalence among women and that patients with fibromyalgia have specific changes in sleep patterns, and there is a significant correlation of this condition with temporomandibular disorders (AU).

Temporomandibular disorders in fibromyalgia syndrome: a short-communication.

Fibromyalgia syndrome (FMS) is a chronic painful syndrome and the coexistence of a painful condition caused by Temporomandibular Disorders (TMD) and FMS has been frequently raised for several studies, however, more likely hypothesis is that a set of FMS characteristics may lead to the onset of TMD symptoms and they are not merely coexisting conditions. Therefore, our aim is presenting a review of literature about the relation between fibromyalgia and the signs and symptoms of temporomandibular disorders. For this purpose, a bibliographic search was performed of the period of 1990-2013, in the Medline, Pubmed, Lilacs and Scielo databases, using the keywords fibromyalgia, temporomandibular disorders and facial pain. Here we present a set of findings in the literature showing that fibromyalgia can lead to TMD symptoms. These studies demonstrated greater involvement of the stomatognathic system in FMS and myogenic disorders of masticatory system are the most commonly found in those patients. FMS appears to have a series of characteristics that constitute predisposing and triggering factors for TMD.

Sleep quality and facial pain in fibromyalgia syndrome.

AIMS: This study aims to evaluate the sleep conditions in fibromyalgia syndrome and the influence of the temporomandibular disorders (TMDs) and fibromyalgia association in self-reported sleep quality. METHODOLOGY: Forty female patients with fibromyalgia (FMS) were compared with 40 healthy women [control group (CG)]. Three questionnaires were used (i.e. RDC/TMD to diagnose TMD and to determine pain intensity and disability and Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) to assess sleep conditions). Statistical analyses were performed using the Wilcoxon-Mann-Whitney test to ordinal variables, Student's t-test to obtain the quantitative total scores of PSQI and chronic pain classification, Spearman's rho to determine the correlation between facial pain and quality sleep, and Fisher's exact test for other variables. RESULTS: A moderate correlation between facial pain intensity and low sleep quality was found (rho = 0·56; P<0·0001); however, TMD and FMS association did not show worse sleep quality (P>0·05). Excessive daytime sleepiness was more prevalent in FMS (37·5%; P<0·0001) besides having the worst sleep quality (PSQI = 12·72) compared with CG (PSQI = 4·62). CONCLUSION: Fibromyalgia patients experience intense facial pain in addition to poor sleep and high disabilities. TMD and FMS association do not appear to worsen this condition; however, facial pain intensity was correlated with low sleep quality.

Chronicity factors of temporomandibular disorders: a critical review of the literature

Facial pain often persists long after any identifiable organic pathology has healed. Moreover, in a subgroup of patients with temporomandibular disorder (TMD), no treatment is effective. Knowledge of factors associated with persistent pain in TMD could help identify personalized treatment approaches. Therefore, we conducted a critical review of the literature for the period from January 2000 to December 2013 to identify factors related to TMD development and persistence. The literature findings showed that chronic TMD is marked by psychological distress (somatization and depression, affective distress, fear of pain, fear of movement, and catastrophizing) and characteristics of pain amplification (hyperalgesia and allodynia). Furthermore, these factors seem to interact in TMD development. In addition, our review demonstrates that upregulation of the serotonergic pathway, sleep problems, and gene polymorphisms influence the chronicity of TMD. We conclude that psychological distress and pain amplification contribute to chronic TMD development, and that interactions among these factors complicate pain management. These findings emphasize the importance of multidisciplinary assistance in TMD treatment.

Quality of life in temporomandibular disorder patients with localized and widespread pain

AIM: To compare temporomandibular (TMD) subgroups classified according to the presence of localized pain (LP) or widespread pain (WP) in order to assess the quality of life domains and verify which components affect most the functional capacity of facial pain patients. METHODS: A cross-sectional study was conducted and the Short Form-36 Health Survey was applied in order to assess quality of life. Thirty-nine TMD/WP patients, 37 TMD/LP patients and 40 subjects free of TMD complaints were evaluated. RESULTS: TMD/WP patients differed significantly from healthy controls in all SF-36 components and TMD/LP patients ranked between them. It was also observed that patients with bodily pain and TMD with WP are respectively, 4.16 and 49.42 times more likely to have low functional capacity. CONCLUSIONS: Functional capacity in TMD subgroups was only affected by the presence of bodily pain and WP. These patients feature high chance of low functional capacity. Furthermore, TMD patients with localized and widespread pain share role-emotional impairments...

Estimulação elétrica de alta voltagem incrementa a cicatrização de lesões cutâneas crônicas: análise de seis casos / High voltage pulsed stimulation increases cicatrization of chronic cutaneous ulcers: analysis of six cases / Estimulación eléctrica de alto voltaje incrementa la cicatrización de úlceras cutáneas crónicas: análisis de seis casos

O tratamento de úlceras cutâneas por estimulação elétrica tem crescido na prática clínica, no entanto, faltam estudos que investiguem a efetividade desse recurso em acompanhamento prolongado ou até que ocorra a cicatrização completa das lesões. Assim, a estimulação elétrica de alta voltagem (EEAV) foi aplicada em úlceras cutâneas crônicas com o objetivo de reduzir a área da lesão. Para tanto, participaram do estudo quatro homens que apresentavam seis úlceras cutâneas que receberam a EEAV (fase=15ms; F=100 Hz; T: 100 a 150 V; fases gêmeas), 2 vezes por semana, durante 30 minutos. O eletrodo com polaridade negativa foi colocado sobre a lesão e o positivo no trajeto vascular. As úlceras foram avaliadas pré e pós-intervenção por meio da fotogrametria, sendo calculada a área da lesão. Como resultado, observamos o fechamento completo da lesão nos sujeitos I e II (área de 4,66 cm² para 0 após 21 sessões e de 1,74 cm² para 0 após 16 sessões, respectivamente). O sujeito III obteve redução de 93% na área da lesão direita (de 2,02 para 0,14 cm²) e na esquerda de 80,40% (de 2,50 para 0,49 cm²), após 100 sessões. No sujeito IV ocorreu o fechamento completo da lesão sacral (de 10,74 cm² para 0) e a redução da lesão isquiática de 11,01 para 2,43 cm², após 75 sessões. Desse modo, concluímos que a EEAV facilitou o processo de cicatrização das úlceras estimuladas, pois as áreas de todas as úlceras apresentaram diminuição superior a 78%, havendo cicatrização completa em três delas...

The treatment of cutaneous ulcers by electrical stimulation in clinical practice has grown, however there are few studies investigating the effectiveness of these individual resources in monitoring and complete healing of the lesions. Thus, High Voltage Pulsed Stimulation (HVPS) was used in chronic skin ulcers with the aim of reduce the area of the lesion. Four male subjects with chronic cutaneous ulcers participated in the study. The treatment of the injury consisted on HVPS application (15 microseconds, 100/150 V, 100 Hz) for 30 minutes, 2 times weekly. The electrode with negative polarity was placed on the lesion and positive on vascular path. The ulcers were assessed pre and post-intervention by photogrammetry, and it was calculated the area of the lesion. As a result, we observed the complete healing in the subjects I and II (respectively, area of 4.66 cm² to 0 after 21 sessions and 1.74 cm² to 0 after 16 sessions). The area of subject III right ulcer obtained reduction of 93% after 100° session (2.02 to 0.14 cm²) and left ulcer obtained reduction of 80.40% (2.50 to 0.49 cm²). In subject IV there was a complete healing of the sacral lesion after 75 sessions (10.74 cm² to 0) and decrease sciatic lesion of 11.01 to 2.43 cm². Thus we conclude that HVPS facilitated the healing process of stimulated ulcers because the areas of all ulcers had decreased more than 78%, and in three of them there was complete healing...

El tratamiento de úlceras cutáneas con el uso de estimulación eléctrica tiene crecido en la práctica clínica, pero no hay muchos estudios que investigaron la efectividad de eso recurso en el acompañamiento prolongado o hasta la ocurrencia de la cicatrización completa de las lesiones. Así, la estimulación eléctrica de alto voltaje (EEAV) fue aplicada en úlceras cutáneas crónicas con el objetivo de reducir la área de la lesión. Para eso, cuatro hombres con seis úlceras cutáneas crónicas participaron del estudio, los cuales habían recibido la EEAV (fase=15ms; F=100 Hz; T: el 100 al 150 V; fases), dos veces por semana, por 30 minutos. Lo electrodo con polaridad negativa fue posicionado sobre la lesión y lo positivo en el trayecto vascular. Las úlceras fueron evaluadas antes y después de la intervención por medio de la fotogrametría, y la área de la lesión fue calculada. Se observó, como resultado, el cierre completo de la lesión en los sujetos I y II (área de 4,66 cm² para 0 después de 21 sesiones y de 1,74 cm² para 0 después de 16 sesiones, respectivamente). El sujeto III obtuvo reducción del 93% en el local de la lesión derecha (de 2,02 para 0,14 cm²) y en la izquierda del 80,40% (del 2,50 para 0,49 cm²) después de 100 sesiones. El cierre completo de la lesión del sacro (del 10,74 cm² para 0) y la reducción de la isquiática del 11,01 para 2,43 cm² ocurrieron en el sujeto IV después de 75 sesiones. Por lo tanto, se concluyo que la EEAV ha facilitado el proceso de cicatrización de las úlceras estimuladas, pues las áreas de todas las úlceras presentaron disminución superior al 78% con cicatrización completa en tres de ellas....

Facial pain associated with fibromyalgia can be marked by abnormal neuromuscular control: a cross-sectional study.

BACKGROUND: Temporomandibular disorder (TMD) development in fibromyalgia syndrome (FMS) is not yet fully understood, but altered neuromuscular control in FMS may play a role in triggering TMD. OBJECTIVE: The purpose of this study was to verify the association between neuromuscular control and chronic facial pain in groups of patients with FMS and TMD. DESIGN: A cross-sectional study was conducted. METHODS: This study involved an analysis of facial pain and electromyographic activity of the masticatory muscles in patients with FMS (n=27) and TMD (n=28). All participants were evaluated according to Research Diagnostic Criteria for Temporomandibular Disorders and surface electromyography (SEMG). Myoelectric signal calculations were performed using the root mean square and median frequency of signals. RESULTS: The data revealed premature interruption of masticatory muscle contraction in both patient groups, but a significant correlation also was found between higher median frequency values and increased facial pain. This correlation probably was related to FMS because it was not found in patients with TMD only. Facial pain and increased SEMG activity during mandibular rest also were positively correlated. LIMITATIONS: Temporal conclusions cannot be drawn from the study. Also, the study lacked a comparison group of patients with FMS without TMD as well as a control group of individuals who were healthy. CONCLUSIONS: Altered neuromuscular control in masticatory muscles may be correlated with perceived facial pain in patients with FMS.

Features of temporomandibular disorders in fibromyalgia syndrome.

This study aimed to investigate the prevalence of clinical features of temporomandibular disorders (TMD) in patients with fibromyalgia. The test group (FMG) consisted of 40 women with fibromyalgia (FM) compared to the control group of 40 healthy subjects using the research diagnostic criteria for temporomandibular disorders (RDC/TMD). The variables were compared using Fisher's exact test and a Mann-Whitney test. Facial pain was reported by 85% of the FM group, and 77.5% were diagnosed with myofascial TMD. Muscle pain during jaw movements, daytime bruxism/clenching, and limited mouth opening were significantly higher in the test group. There was no difference between groups in: (1) joint noises; (2) sleep bruxism/clenching; and (3) excursive or non-excursive movements. Classic signs of TMD, such as joint noise and self-reporting of clenching at night, are not associated with fibromyalgia syndrome as demonstrated in the current study. However, the self-reported daytime parafunctions, muscle pain in jaw movements, and limited mouth opening are features of the patients in the current study. This study revealed specific muscle involvement of TMD is also presence in FM.

Temporomandibular disorders in fibromyalgia: a critical view / Disfunção temporomandibular na fibromialgia: uma visão crítica

Temporomandibular disorders (TMD) and fibromyalgia (FM) are musculoskeletal syndromes that appear to be associated to each other. Various studies throughout the literature relate the signs and symptoms of TMD in patients with FM. The objective of this study was to analyze the literature regarding clinical association between FM and TMD. Even though these conditions present different etiologies, the pain modulating mechanisms are similar. Many studies in this field aim to elucidate questions which are still little understood. However, it has been observed that these syndromes are characterized by a reduction in pain threshold and in the attenuation capabilities of descending pain modulating systems. Moreover, there is a certain degree of comorbidities between these two pathologies, which share many clinical characteristics. Numerous patients with FM present various signs and symptoms of TMD, while only a small quantity of individuals with TMD is diagnosed with FM. Therefore, an adequate and precise evaluation of the stomatognathic system in patients with FM, which encompasses TMD diagnosis in therapeutic intervention, is paramount.

A disfunção temporomandibular (DTM) e a fibromialgia (FM) são síndromes musculo-esqueléticas que parecerem estar associadas. Vários estudos na literatura relatam sinais e sintomas da DTM em pacientes com FM. O objetivo deste trabalho foi analisar a literatura quanto à associação clínica entre fibromialgia e as disfunções temporomandibulares. Apesar de estes distúrbios possuírem etiologias diferentes, o mecanismo de modulação de dor é semelhante. Muitas pesquisas desenvolvidas nessa área buscam elucidar esta questão ainda pouco compreendida. Mas sugere-se que estas síndromes são caracterizadas por uma diminuição no limiar de dor e na capacidade de atenuação de sistemas descendente de modulação da dor. Além disso, há certo grau de comorbidade entre estas duas patologias, que compartilham muitas características clínicas. Muitos pacientes com FM apresentam vários sinais e sintomas de DTM, entretanto, uma pequena quantidade de indivíduos com DTM recebem um diagnóstico de FM. Portanto, é importante uma avaliação precisa e adequada do sistema estomatognático em pacientes com fibromialgia englobando o diagnóstico de disfunção temporomandibular na intervenção terapêutica