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1.
J Chem Phys ; 160(2)2024 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-38205853

RESUMO

Event-Chain Monte Carlo (ECMC) methods generate continuous-time and non-reversible Markov processes, which often display significant accelerations compared to their reversible counterparts. However, their generalization to any system may appear less straightforward. In this work, our aim is to distinctly define the essential symmetries that such ECMC algorithms must adhere to, differentiating between necessary and sufficient conditions. This exploration intends to delineate the balance between requirements that could be overly limiting in broad applications and those that are fundamentally essential. To do so, we build on the recent analytical description of such methods as generating piecewise deterministic Markov processes. Therefore, starting with translational flows, we establish the necessary rotational invariance of the probability flows, along with determining the minimum event rate. This rate is identified with the corresponding infinitesimal Metropolis rejection rate. Obeying such conditions ensures the correct invariance for any ECMC scheme. Subsequently, we extend these findings to encompass schemes involving deterministic flows that are more general than mere translational ones. Specifically, we define two classes of interest of general flows: the ideal and uniform-ideal ones. They, respectively, suppress or reduce the event rates. From there, we implement a comprehensive non-reversible sampling of a system of hard dimers by introducing rotational flows, which are uniform-ideal. This implementation results in a speed-up of up to ∼3 compared to the state-of-the-art ECMC/Metropolis hybrid scheme.

2.
Artigo em Inglês | MEDLINE | ID: mdl-36232261

RESUMO

OBJECTIVES: To estimate the evolution of compressible absenteeism in a hospital center and identify the professional and sociodemographic factors that influence absenteeism. METHOD: All hospital center employees have been included over a period of twelve consecutive years (2007 to 2019). Compressible absences and occupational and sociodemographic factors were analyzed using Occupational Health data. Since the distribution of the data did not follow a normal distribution, the number of days of absence was presented as a median (interquartile range (IQR): 1st quartile-3rd quartile), and comparisons were made using non-parametric tests followed by a negative binomial model with zero inflation (ZINB). RESULTS: A total of 16,413 employees were included, for a total of 2,828,599 days of absence, of which 2,081,553 were compressible absences (73.6% of total absences). Overall, 42% of employees have at least one absence per year. Absent employees had a median of 15 (IQR 5-53) days of absence per year, with an increase of a factor of 1.9 (CI95 1.8-2.1) between 2007 and 2019 (p < 0.001). Paramedical staff were most at risk of absence (p < 0.001 vs. all other occupational categories). Between 2007 and 2019, the number of days of absence was multiplied by 2.4 (CI95 1.8-3.1) for administrative staff, 2.1 (CI95 1.9-2.3) for tenured, 1.7 (CI95 1.5-2.0) for those living more than 12 km from the workplace, 1.8 (CI95 1.6-2.0) among women, 2.1 (CI95 1.8-2.6) among those over 50 years of age, 2.4 (CI95 1.8-3.0) among "separated" workers, and 2.0 (CI95 1.8-2.2) among those with at least one child. CONCLUSIONS: Paramedical personnel are most at risk of absenteeism. Meanwhile, absenteeism is increasing steadily, and overall, the increase is major for administrative staff. The profile of an employee at risk of absenteeism is a titular employee, living at distance from work, probably female, over 50 years old, separated, and with children. Identifying professionals at risk of absenteeism is essential to propose adapted and personalized preventive measures.


Assuntos
Absenteísmo , Saúde Ocupacional , Criança , Feminino , Hospitais , Humanos , Pessoa de Meia-Idade , Ocupações , Local de Trabalho
3.
Artigo em Inglês | MEDLINE | ID: mdl-35886088

RESUMO

Increased absenteeism in health care institutions is a major problem, both economically and health related. Our objectives were to understand the general evolution of absenteeism in a university hospital from 2007 to 2019 and to analyze the professional and sociodemographic factors influencing this issue. An initial exploratory analysis was performed to understand the factors that most influence absences. The data were then transformed into time series to analyze the evolution of absences over time. We performed a temporal principal components analysis (PCA) of the absence proportions to group the factors. We then created profiles with contributions from each variable. We could then observe the curves of these profiles globally but also compare the profiles by period. Finally, a predictive analysis was performed on the data using a VAR model. Over the 13 years of follow-up, there were 1,729,097 absences for 14,443 different workers (73.8% women; 74.6% caregivers). Overall, the number of absences increased logarithmically. The variables contributing most to the typical profile of the highest proportions of absences were having a youngest child between 4 and 10 years old (6.44% of contribution), being aged between 40 and 50 years old (5.47%), being aged between 30 and 40 years old (5.32%), working in the administrative field (4.88%), being tenured (4.87%), being a parent (4.85%), being in a coupled relationship (4.69%), having a child over the age of 11 (4.36%), and being separated (4.29%). The forecasts predict a stagnation in the proportion of absences for the profiles of the most absent factors over the next 5 years including annual peaks. During this study, we looked at the sociodemographic and occupational factors that led to high levels of absenteeism. Being aware of these factors allows health companies to act to reduce absenteeism, which represents real financial and public health threats for hospitals.


Assuntos
Absenteísmo , Ocupações , Adulto , Criança , Pré-Escolar , Feminino , Hospitais Universitários , Humanos , Masculino , Pessoa de Meia-Idade
4.
J Math Biol ; 81(2): 575-602, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32705306

RESUMO

The Moran discrete process and the Wright-Fisher model are the most popular models in population genetics. The Wright-Fisher diffusion is commonly used as an approximation in order to understand the dynamics of population genetics models. Here, we give a quantitative large-population limit of the error occurring by using the approximating diffusion in the presence of weak selection and weak immigration in one dimension. The approach is robust enough to consider the case where selection and immigration are Markovian processes, whose large-population limit is either a finite state jump process, or a diffusion process.


Assuntos
Genética Populacional , Modelos Genéticos , Difusão , Genética Populacional/métodos , Seleção Genética
5.
Sci Rep ; 9(1): 6097, 2019 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-30967615

RESUMO

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

6.
Sci Rep ; 9(1): 1449, 2019 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-30723244

RESUMO

Volcanic ash clouds are common, often unpredictable, phenomena generated during explosive eruptions. Mainly composed of very fine ash particles, they can be transported in the atmosphere at great distances from the source, having detrimental socio-economic impacts. However, proximal settling processes controlling the proportion (ε) of the very fine ash fraction distally transported in the atmosphere are still poorly understood. Yet, for the past two decades, some operational meteorological agencies have used a default value of ε = 5% as input for forecast models of atmospheric ash cloud concentration. Here we show from combined satellite and field data of sustained eruptions that ε actually varies by two orders of magnitude with respect to the mass eruption rate. Unexpectedly, we demonstrate that the most intense eruptions are in fact the least efficient (with ε = 0.1%) in transporting very fine ash through the atmosphere. This implies that the amount of very fine ash distally transported in the atmosphere is up to 50 times lower than previously anticipated. We explain this finding by the efficiency of collective particle settling in ash-rich clouds which enhance early and en masse fallout of very fine ash. This suggests that proximal sedimentation during powerful eruptions is more controlled by the concentration of ash than by the grain size. This has major consequences for decision-makers in charge of air traffic safety regulation, as well as for the understanding of proximal settling processes. Finally, we propose a new statistical model for predicting the source mass eruption rate with an unprecedentedly low level of uncertainty.

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