Contribution of DNA methylation to the pathogenesis of Sjögren's syndrome: A review.

Sjögren's syndrome (SS) is a chronic systemic disease characterised by salivary and lacrimal gland dysfunction with severe implications for the well-being of bearing individuals. Although its origin has not yet been fully elucidated, it is known that genetic, environmental, and epigenetic factors are important contributors to the pathogenesis of this syndrome. DNA methylation is a relevant, widely studied epigenetic factor that is possibly related to the establishment of SS. The aim of the present study was to perform a systematic review of the literature to compile studies on the contribution of DNA methylation to the pathogenesis of SS. A literature search was performed in 4 databases (PubMed, Web of Science, Lilacs, and Scopus) using previously selected Medical Subject Headings (MESH) descriptors, and article selection considered observational studies only. After a full-text reading of the selected articles, 15 studies were in accordance with the eligibility criteria for data extraction. Methylation detection approaches included global methylation, genome-wide assessment of differentially methylated regions, and site-specific methylation. Fourteen articles reported associations of DNA methylation profiles in SS patients, both globally and in several genes in salivary glands and blood cells. Thus, DNA methylation may contribute to the pathogenesis of SS. The findings reinforce the importance of epigenetic markers in the dynamics of SS and may direct efforts toward the development of new diagnostic and therapeutic approaches.

Sistemas de encaixe em prótese removível ­ revisão de literatura / Association of attachments in removable prosthesis ­ literature review

A reabilitação oral de pacientes parcialmente dentados é versátil e pode ser realizada a partir de várias opções de tratamentos. Os sistemas de encaixes em Próteses Parciais Removíveis (PPR) são opções clínicas disponíveis idealizadas a fim de melhorar as limitações estéticas e funcionais das PPRs. O objetivo deste estudo foi descrever sobre os sistemas de encaixes em prótese parcial removível, elencando suas principais indicações, contraindicações, vantagens e desvantagens a partir de uma revisão de literatura. A revisão foi realizada utilizando-se a base de dados PubMed, SciELO e Lilacs para identificar todos os artigos publicados em português, inglês e espanhol acerca do tema abordado, sendo selecionados aqueles relatos de caso único ou série de casos. As palavras-chave utilizadas foram: "Prótese parcial removível", "Encaixe de precisão de dentadura", "Prótese dentária". A partir das indicações, contraindicações, vantagens e desvantagens do tratamento reabilitador com próteses parciais com sistemas de encaixe, entende-se que com um planejamento clínico e laboratorial adequado, essa opção de tratamento pode proporcionar um excelente resultado para os pacientes parcialmente edêntulos.

Oral rehabilitation for partially edentulous patient is carried out on various treatment options. The attachment systems (clasps) for Removable Partial Dentures (RPD) are available clinical choices idealized to improve the aesthetic and functional limitations of the RPDs. This study aimed at describing the attachment systems of removable partial denture, highlighting their main indications, contraindications, advantages and disadvantages from a literature review. The literature review was carried out using the PubMed, SciELO and Lilacs database to identify all the articles published in Portuguese, English and Spanish languages about the topic, selecting single case and case series report. The key words used were: "Denture, partial, removable", "Denture Precision Attachment", "Dental Prosthesis." Considering the indications, contraindications, advantages and disadvantages of the rehabilitation treatment with partial dentures with attachment system, when performed following an adequate clinical and laboratory planning, this treatment option can provide an excellent result for partially edentulous patient.