Reverse shoulder arthroplasty for fracture sequelae: How the initial fracture treatment influences the outcomes of joint replacement.

OBJECTIVE: The aim of this study was to analyze and compare the results of reverse shoulder arthroplasty (RSA) in proximal humeral fracture sequelae (PHFS) in fractures initially treated conservatively versus those initially treated with open reduction and internal fixation (ORIF). METHODS: It is a retrospective study that includes all PHFS treated with a RSA from September 2006 to December 2013. Twenty-seven patients met the inclusion criteria. There were 9 patients (7 females and 2 males; mean age: 79.11 years) treated with RSA due to a fracture sequelae following conservative treatment and 18 patients (15 females and 3 males; mean age: 76.83 years) treated with a RSA owing to a fracture sequelae after ORIF. The functional outcome was recorded with the aid of the pre-surgery Constant Score and at the latest follow-up (minimum of two years). All the patients included underwent an imaging study that included plain X-Rays and a CT scan prior to surgery and plain X-Rays after surgery. All complications and reoperations during follow-up were also recorded. RESULTS: Both groups had significantly increased Constant Scores after surgery (p < 0.0001), but the patients in the conservative group had significantly better outcomes for the total Constant Score (p = 0.024), for forward elevation (p = 0.026) and for external rotation (p = 0.004). A total of 4 complications (14.8%) were present during the follow-up period. In the conservative group, 1 patient developed an infection and there were 2 dislocations and 1 infection in the ORIF group. CONCLUSION: The use of RSA in the treatment of PHFS results in a limited outcome improvement but with an acceptable complication rate. Patients developing PHFS after conservative treatment may expect better outcomes and fewer complications than those developing PHFS after ORIF. LEVEL OF EVIDENCE: Level IV, Therapeutic Study.

Preoperative antibiotic prophylaxis in prosthetic joint infections: not a concern for intraoperative cultures.

BACKGROUND: Culture negative prosthetic joint infections (PJI) still remain an issue even with the advantages of the new diagnostic tools for PJI. This is why some orthopedic surgeons have reservations relative to the use of preoperative antibiotic prophylaxis when a PJI is suspected. The purpose of the present study was to evaluate the influence of preoperative antibiotic prophylaxis on intraoperative cultures. MATERIAL AND METHODS: An enhanced diagnostic protocol for PJI (Zimmerli criteria) was used for the inclusion criteria in order to collect all PJI that were seen in a university hospital. Patients were prospectively randomized into two groups. The control group received the classical preoperative antibiotic prophylaxis. The study group did not receive prophylaxis prior to surgery. RESULTS: There were 14 patients in each group. They correspond to 13 total hip arthroplasty infections, 12 total knee arthroplasty infections and 3 reverse shoulder prosthesis infections. There were 10 patients in the study group and 10 patients in the control group with at least one positive microbiological criterion (P > 0.05). There were 4 patients in each group with a culture negative PJI (P > 0.05). CONCLUSIONS: Preoperative antibiotic prophylaxis does not affect intraoperative cultures in suspected or confirmed PJI. Therefore it is essential to deliver antibiotic prophylaxis in any patient in which a prosthesis is to be implanted in order to protect the prosthesis from infection.

Influence of glenosphere size on the development of scapular notching: a prospective randomized study.

HYPOTHESIS: The objective of the study was to evaluate the development of scapular notching in reverse shoulder arthroplasty by comparing larger glenospheres (42 mm) with smaller glenospheres (38 mm). METHODS: This was a prospective randomized study of 81 patients who had undergone reverse shoulder arthroplasty with a 2-year follow-up. Patients were randomized to receive either a 42-mm glenosphere (38 patients) or a 38-mm glenosphere (43 patients). Scapular notching development was assessed with an anteroposterior radiograph at the end of the follow-up. Functional outcome was assessed with the Constant score before surgery and at the end of follow-up. An independent blinded observer carried out radiologic and clinical assessments. RESULTS: Scapular notching was present in 48.8% of the patients receiving a 38-mm glenosphere and in 12.1% of the patients receiving one of 42 mm, with significant differences between both (P < .001). No significant differences were noted between the 2 glenosphere size groups in terms of the total Constant score. Patients with a 42-mm glenosphere had a mean glenoid-glenosphere overhang of 6.1 mm, whereas patients with a 38-mm glenosphere had one of 4.2 mm, with significant differences between them (P < .001). No significant differences in the total Constant score were found between the patients whether they had scapular notching or not. CONCLUSION: Bigger glenospheres (42 mm) significantly reduce development of scapular notching compared with smaller glenospheres (38 mm). Glenosphere size has no significant influence on functional outcomes measured with the Constant score.

Superficial wound infection does not cause inferior clinical outcome after TKA.

PURPOSE: Superficial wound infections do not lead to chronic prosthetic joint infection. Therefore, it has been hypothesized that a superficial infection of a surgical wound following a successfully treated TKA does not lead to a lower functional outcome at long-term follow-up. This may be due to early diagnosis and proper treatment without interrupting the rehabilitation programme. The purpose of this study was to support the hypothesis by comparing the functional outcome and health-related quality of life (HRQoL) of superficial infections treated successfully after primary total knee arthroplasty (TKA). METHODS: In a 3000 prospective TKA cohort, 45 superficial infections were compared to a control group of 629 TKA without complications. The functional outcome, health quality, expectations and revision rate were compared between the study and control groups. RESULTS: The groups were comparable in terms of demographic values and preoperative scores. The mean follow-up was 74.57 months (SD ± 7.1). No statistical differences were observed relative to functional outcomes at the final follow-up as measured with the Knee Society Score (156.9 vs 168.4; n.s) and range of motion (0.2-114.4 vs 0.7-112.3; n.s). For the HRQoL, no differences in the physical (40.0 vs 40.6; n.s) and mental (43.2 vs 45.8; n.s) SF-36 scores were found. Neither were there differences in post-operative expectations and the revision rate. CONCLUSIONS: In a long-term follow-up, a different clinical outcome and HRQoL were not obtained after a successfully treated superficial infection following a TKA when compared to a TKA without complications. Based on the findings of the study, additional complications are not anticipated after a successfully treated superficial wound infection in TKA. Therefore, a different follow-up to that of a non-complicated TKA is not recommended when the early post-operative superficial wound infection has been appropriately treated. A superficial infection successfully treated in the acute post-operative period should be considered solved at long-term follow-up. LEVEL OF EVIDENCE: Therapeutic study, Level III.

The minimal clinically important difference for function and strength in patients undergoing reverse shoulder arthroplasty.

HYPOTHESIS: Despite a statistically significant improvement in functional scores after receiving a reverse shoulder arthroplasty (RSA) in a cuff-deficient shoulder, not all patients perceive a minimal clinically important difference (MCID) in every functional domain of the score. METHODS: This was a prospective longitudinal study including 60 consecutive patients with a cuff-deficient shoulder treated with a RSA. The Constant score was recorded before surgery and at a 1-year follow-up assessment. At the 1-year follow-up, all patients also filled out a 15-item anchor questionnaire to assess their perception of change in their overall function, forward elevation, lateral rotation, internal rotation, and strength to determine the MCID. RESULTS: The mean Constant score was 30.1 (standard deviation, 10.7) before surgery and was 58.4 (standard deviation, 16.2) at the 1-year follow-up, with statistically significant improvement (P < .001). A statistically significant improvement was found in the domains of forward elevation (P < .001), lateral rotation (P < .001), and strength (P < .001) except for internal rotation (P = .15). The MCID for overall function, forward elevation, lateral rotation, internal rotation, and strength in the Constant score increased by 8, 6, 2, 2, and 11.5 points, respectively; only 46.7%, 20%, 50%, 45.8%, and 33.3% of the patients, respectively, exceeded the MCID on each domain after surgery. CONCLUSIONS: A statistically significant improvement in the Constant score is expected after receiving an RSA in a cuff-deficient shoulder, but a considerable number of patients do not reach the MCID in the function and strength domains. A small improvement in rotation is perceived to be beneficial by patients, whereas large improvements in forward elevation are required for the improvement to be perceived to be beneficial.

Use of antibiotic-loaded cement in total knee arthroplasty.

Bone cement has the capacity to release antibiotic molecules if any antibiotic is included in it, and these elution properties are improved as cement porosity is increased. In vitro studies have shown high local antibiotic concentration for many hours or few days after its use. Antibiotic loaded bone cement (ALBC) is helpful when treating an infection in total knee arthroplasty (TKA) revision surgery. The purpose of this paper was to review the evidence for the routine use of ALBC in TKA in the literature, its pros and cons. Many authors have recommended the use of ALBC also in primary TKA for infection prophylaxis, but the evidence based on data from National Registries, randomized clinical trials and meta-analysis suggest a protective effect of ALBC against infection when used in hips, but not (or only mild) in knees. A possible explanation to this finding is that the duration and quantity of locally elevated antibiotic levels after surgery are smaller in TKA, due to the smaller amount of cement used for fixation in TKA-only a layer in the bone surface. There are some concerns about the routine use of ALBC in primary TKA as prophylaxis against infection: Firstly, there is a risk of hypersensivity or toxicity even when the chance is highly improbable. Secondly, there is a reduction in the mechanical properties of the cement, but this can be probably neglected if the antibiotic is used in low doses, not more than 1 g per 40 g cement package. Another significant concern is the increased economic cost, which could be overlooked if there were enough savings in treating fewer prosthetic infections. Finally, there is also a risk of selection of antibiotic-resistant strains of bacteria and this could be the main concern. If used, the choice of the antibiotic mixed in ALBC should consider microbiological aspects (broad antimicrobial spectrum and low rate of resistant bacteria), physical and chemical aspects (thermal stability, high water solubility), pharmacological characteristics (low risk to allergic reactions or toxicity) and economic aspects (not too expensive). The most commonly used antibiotics in ALBC are gentamicin, tobramycin and vancomycin. In conclusion, there is a paucity of randomized clinical trials in the use of ALBC in primary TKAs and the actual evidence of the effect of ALBC in reducing the risk of infection is insufficient. This, in addition to concerns about patient safety, risks of increase in the antibiotic resistance of microorganisms and the increase in costs in the procedure, lead us to recommend a cautious use of ALBC, perhaps only in high-risk patients (immunocompromised, morbidly obese, diabetic and patients with previous history of fracture or infection around the knee) unless the benefits of ALBC use were fully proven. Meanwhile, the rigorous use of peri-operative prophylactic systemic antibiotics and adoption of efficient antiseptic procedures and improved surgical techniques must be considered the gold standard in infection prevention in TKA surgery.

Cervical paravertebral osteolipoma: case report and literature review.

Lipomas are the most frequent soft tissue tumors. Osteolipomas are a rare variant that can be difficult to diagnose. We report the case of a 66-year-old man consulting with a tumor of 2 years development in the right paravertebral cervical region. Neurologically, the patient had no sign of myelopathy or neurological focality. Magnetic resonance imaging showed a mass with a lipid component and calcifications inside within the right paravertebral musculature with a possible origin in the right C3 posterior root. A computed tomography scan and guided biopsy were performed, revealing hematic material and small bone spicules with no apparent neoplastic element. The tumor was totally removed, including the right C3 posterior branch, and was confirmed to be an osteolipoma on biopsy. The patient remains asymptomatic at 6-month follow-up. The osteolipoma is a benign tumor of soft tissue, characterized by lipoma areas with mature bone tissue differentiation, and even with hematopoietic marrow.

Long term follow-up of successfully treated superficial wound infections following TKA.

The relevance of wound complications in association with acute prosthetic joint infection (PJI) is well known. However, whether a successfully treated superficial infection can result in a chronic deep infection remains unclear. The aim of this study was to determine the prevalence, treatment and late complications of superficial wound infections following TKA. In a 3000 TKA prospective cohort, 45 superficial infections were diagnosed and treated successfully with antibiotic therapy along with or without surgical debridement. None of the cases developed deep chronic PJI at 70 months of follow-up. Three cases were in need of a TKA exchange due to aseptic loosening. A successfully treated superficial wound infection does not result in a chronic deep TKA infection.

Treatment of fracture sequelae of the proximal humerus: comparison of hemiarthroplasty and reverse total shoulder arthroplasty.

INTRODUCTION: Fracture sequelae (FS) of the proximal humerus is a challenging scenario in shoulder surgery. Despite they have been traditionally treated with hemiarthroplasty (HA), the use of reverse shoulder arthroplasty (RSA) has been recently introduced. However, there are no studies comparing the results of HA and RSA in FS. The purpose of this study was to compare the functional and quality of life-related outcomes, and complications in the treatment of proximal humeral FS between HA and RSA. MATERIALS AND METHODS: A therapeutic prospective non-randomized comparative study was conducted. All consecutive patients with diagnosis of FS after non-operative treatment of proximal humeral fractures and no previous shoulder surgery were considered for this study. A total of 32 patients (24 females, 8 males) with a mean (SD) age at the time of surgery of 80.1 (4.9) years were finally included: 12 in the HA group, and 20 in the RSA group. FS were treated with shoulder arthroplasty by the implantation of either HA or RSA. Constant score (total and specific items), quality of life (assessed through SF-36), and complications requiring revision surgery were compared between groups. RESULTS: All parameters of the Constant score significantly improved in the postoperative compared to preoperative period when considering the entire sample. The RSA group demonstrated a higher improvement in total Constant score (p = 0.06) and Constant activity level (p = 0.02) compared to the HA group. The HA demonstrated a higher number of complications compared to the RSA (p = 0.05). There were no differences in SF-36 scores between both groups. CONCLUSIONS: The shoulder arthroplasty is an effective treatment for FS with significant improvement in pain and function. The RSA may be a better option than HA for FS given the trend towards better total Constant score and a significantly lower number of complications requiring revision surgery. LEVEL OF EVIDENCE: Therapeutic level II evidence.

The use of erythromycin and colistin-loaded cement in total knee arthroplasty does not reduce the incidence of infection: a prospective randomized study in 3000 knees.

BACKGROUND: The use of antibiotic-loaded cement is believed to prevent infection in primary total knee arthroplasty, but there is a lack of randomized studies to support this concept. The aim of this study was to evaluate the use of an antibiotic-loaded cement to reduce the infection rate in primary total knee arthroplasty. METHODS: This is a prospective randomized study with 2948 cemented total knee arthroplasties, in which bone cement without antibiotic was used in 1465 knees (the control group) and a bone cement loaded with erythromycin and colistin was used in 1483 knees (the study group). All patients received the same systemic prophylactic antibiotics. The patients were followed for a minimum of twelve months. The rate of infection was analyzed according to the criteria of the Centers for Disease Control and Prevention. RESULTS: The rate of deep infection (1.4% in the control group and 1.35% in the study group; p = 0.96) and the rate of superficial infection (1.2% and 1.8%, respectively; p = 0.53) were similar in both groups. The factors related to a higher rate of deep infection in a multivariate analysis were male sex and an operating time of >125 minutes. CONCLUSIONS: The use of erythromycin and colistin-loaded bone cement in total knee arthroplasty did not lead to a decrease in the rate of infection when systemic prophylactic antibiotics were used, a finding that suggests that the use of antibiotic-loaded bone cement would not be indicated in the general population. Further research is needed to assess whether its use is recommended for patients with a higher risk of infection.

Comparison of quality of life between elderly patients undergoing TKA.

The purpose of this study was to compare the short-term changes in quality of life for patients younger than 80 years with those 80 years and older undergoing total knee arthroplasty (TKA). It was hypothesized that patients 80 years and older had a similar quality of life after TKA compared with those younger than 80 years.All consecutive patients undergoing primary TKA were enrolled in this prospective, comparative, prognostic (level I evidence) study and were stratified into 2 groups based on their age (younger than 80 years and 80 years and older). Data on quality of life assessed using the Short Form 36 health survey were obtained preoperatively and 1 year postoperatively (short-term follow-up) and were compared between groups. A total of 328 (83.89%) patients younger than 80 years (mean age, 70.7 years) and 63 (16.11%) patients 80 years and older (mean age, 82.1 years) were included. No significant differences in preoperative quality of life were observed between groups. Postoperative physical function, vitality, social function, and physical component summary were lower in patients 80 years and older. Older patients had a lower difference between pre- and postoperative values in Short Form 36 physical function and role-emotional scores.Patients 80 years and older had a similar improvement in quality of life 1 year after TKA compared with patients younger than 80 years. Therefore, changes in quality of life justify TKA as a treatment option for elderly patients with end-stage knee osteoarthritis.