[Mutagenic action of latex polymerization stabilizers in various test systems]. / Izuchenie mutagennogo deistviia stabilizatorov polimerizatsii lateksov v razlichnykh test-sistemakh.

The cytogenetic activity of latex polymerization stabilizers (monoethanolamine, triethanolamine and neozon-D) is investigated in three different test systems. It is shown that monoethanolamine and triethanolamine are weak inductors of chromosome breaks in the culture of human lymphocytes and in the Crepis capillaris seeds and induce low levels of gene mutations in the Ames systems. The third stabilizer--neozon-D manifests higher mutagenic activity and definite cytotoxic effect. Monoethanolamine and triethanolamine as to their weak mutagenic effect are recommended as preferable stabilizers to be used in the latex industry.

[Modification of an immunoradiometric analysis method and the coagglutination reaction in the diagnosis of meningitis]. / Modifikatsiia metoda immunoradiometricheskogo analiza i reaktsiia koaggliutinatsii v diagnostike meningitov.

The coagglutination test and the radio-immunoassay (RIA) in the authors' modification have been used for the rapid diagnosis of meningococcal meningitis. This modification of RIA has been found to be highly sensitive with respect to soluble microbial antigens. In the study of liquors from patients with acute meningitides of different etiology RIA has been shown to have a higher efficiency in comparison with the coagglutination test. The data thus obtained indicate good prospects for the use of RIA in experimental and diagnostic investigations.

[Patterns of antimicrobial immunity in carriers of toxigenic diphtheria bacteria]. / Zakonomernosti antimikrobnogo immuniteta u nositelei toksigennykh difteriinykh bakterii

It was shown in the passive hemagglutination test (PHAT) with a type-specific somatic antigen on 147 carriers of toxigenic diphtheria bacilli that the PHAT titres of 1/80 and over were determined in 64% of bacteria. In the process of carrier state of toxigenic bacteria antimicrobial antibodies were detected in 79% of the children; after the release from the carrier state, the percentage was from 57 to 26, depending on the time lapse after it. Among the carriers of nontoxigenic diphtheria bacilli the PHAT titre of 1/80 and over was established in up to 20% of children, and only in those which were in the focus of toxigenic bacilli carriers. The applied test could be used for epidemiological purpose to determine the spread of the carrier state of toxigenic bacteria in a collective body.