[The role of quantitative determination of the volume fraction of interstitial collagen and fibronectin in the pathogenesis of myocardial remodeling in dilated cardiomyopathy]. / Rol' kolichestvennogo opredeliniia ob''emnoi fraktsii interstitsial'nogo kollagena i fibronektina v patogeneze remodelirovaniia miokarda pri dilatatsionnoi kardiomiopatii.

The role of myocardial fibrosis in the pathogenesis of left-ventriclar remodeling was studied in patients with idiopathic and ischemic dilatation cardiomyopathy. The percentage of volumic collagen fraction in the left-ventricular myocardium was significantly increased, this increase correlating with the degree of dilatation of left-ventricular cavity. A sufficient increase of plasma fibromectin level was observed in patients with idiopathic dilatation cardiomyopathy at all stages of circulatory insufficiency.