RESUMO
The aim of this study was to estimate the frequencies of some DNA polymorphisms of two genes of the renin-angiotensin system (RAS), M235T angiotensinogen gene and insertion-deletion polymorphism in angiotensin-converting enzyme gene, in older (>55 years old) myocardial infarction survival and control groups. For this purpose 198 myocardial infarction (MI) patients and 152 randomly selected healthy persons have been analyzed. We have not found any differences in allele and genotype distribution in the above-mentioned genes for either group. However, statistical research showed a significant increase of double homozygotes IITT in the group of MI patients as compared with those in the control group. In this respect we suggested that gene-gene interaction in the RAS system may be considered to be a predisposing factor for MI development.
Assuntos
Angiotensinogênio/genética , Epistasia Genética , Predisposição Genética para Doença/genética , Infarto do Miocárdio/genética , Peptidil Dipeptidase A/genética , Sistema Renina-Angiotensina/genética , Adolescente , Idoso , Idoso de 80 Anos ou mais , Alelos , Substituição de Aminoácidos/genética , Criança , Frequência do Gene/genética , Homozigoto , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/mortalidade , Polimorfismo Genético/genética , Federação Russa , Deleção de Sequência/genéticaRESUMO
Genotyping of angiotensin-converting enzyme (ACE) using polymerase chain reaction was conducted in 184 males with acute macrofocal infarction versus 72 males free of arterial hypertension and ischemic heart disease (controls). The age of the patients ranged from 30 to 70 years. Normotensive patients who survived myocardial infarction at the age under 60 had significantly more frequent genotype DD (in the system I/D-polymorphism of ACE gene) than controls or hypertensive patients. The involvement of genotype DD in the onset of myocardial infarction in normotensives was observed at the middle, presenile and senile age. A significant association was found between hereditary IHD loading and carriage of DD genotype in normotensive patients with myocardial infarction.
