[Indices of left ventricular hypertrophy based on data from the automatic mapping of 35 ECG leads]. / Pokazateli gipertrofii levogo zheludochka po dannym avtomaticheskogo kartirovaniia 35 otvedenii EKG.

The potential of the method of 35 ECG leads' automatic mapping in the diagnosis of left ventricular hypertrophy was assessed for the first time. A number of mapping indices closely correlating with the myocardial mass and the thickness of the left ventricular wall were found while studying 35 ECG leads' maps followed by computer processing, in 28 hypertensive patients and 6 normal subjects the hypertrophy degree of the left ventricle being determined by echocardiography and X-rays. The index of the total maximum of the R-waves among 7 vertical columns (7.3 +/- 2.0 cm) proved to be simultaneously highly specific (88.9%), sensitive (84%) and accurate (85.3%) to diagnose even a moderate degree of left ventricular hypertrophy (with the left ventricular mass of 150-200 g as evaluated by echocardiography).

[Mechanism of regulation of themitochondrial creatine phosphokinase reaction by magnewium ions]. / Mekhanizm reguliatsii mitokhondrial'noi kreatinfosfokinaznoi reaktsii ionami magniia

The method of mathematical modelling and kynetic analysis was used to study the mechanism of the regulatory effect of magnesium ions on the creatinephosphokinase reaction in cardiac mitochondria. The regulatory effect of magnesium was shown to originate from the competition between ATP and ADP and the magnesium-complex-formation reaction, and the actual regulator proves to be MgADP. On the basis of the data obtained it is postulated that creatinephosphokinase in cardiac mitochondria is functionally connected with ATP-ADP-translocase. The obtained data permit to believe that the mitochondrial cratinephosphokinase is one of the key links in the process of energy transport in the cardiac cells.