RESUMO
The present study investigated the efficacy of topical selamectin for elimination of naturally acquired Trichosomoides crassicauda infection in rats. Twelve T. crassicauda-positive rats were assigned to the treatment group and six rats were assigned to the control group. Selamectin (6 mg/kg) was applied topically to the skin in a single spot at the base of the neck in front of the scapulae in the treatment group. To assess the efficacy of the treatment, animal faeces were investigated with the use of the flotation technique on days 0, 4, 14 and 24 after selamectin application. The rats of the treatment and control groups were necropsied on the day 24. In the treatment group, 7 of 12 infected rats were cured completely. Topical selamectin was found to be effective in eliminating T. crassicauda infection in rats.
Assuntos
Antiparasitários/uso terapêutico , Infecções por Enoplida/veterinária , Ivermectina/análogos & derivados , Doenças dos Roedores/tratamento farmacológico , Administração Tópica , Animais , Infecções por Enoplida/tratamento farmacológico , Fezes/parasitologia , Ivermectina/uso terapêutico , Distribuição Aleatória , Ratos , Fatores de Tempo , Resultado do Tratamento , TrichuroideaRESUMO
Efficacy of selamectin was studied in naturally acquired S. muris infections in rats. Fourty-eight S. muris-positive rats were divided into six treated and two control groups. Selamectin (6 mg/kg) was applied topically to the skin in a single spot at the base of the neck in the treatment group. The rats of treated and control groups were necropsied on the 24th day after the treatment. Topical selamectin was found to be 40.7-63.3% effective (based on egg per gram method) in eliminating S. muris infection in rats. The efficacy of the treatment against S. muris (based on adult worm counts) in male and female rats was 35.14-58.88%, respectively (mean 48.39%).
Assuntos
Ivermectina/análogos & derivados , Infecções por Nematoides/veterinária , Oxyuroidea , Doenças dos Roedores/parasitologia , Animais , Animais de Laboratório , Anti-Helmínticos/administração & dosagem , Anti-Helmínticos/uso terapêutico , Ivermectina/administração & dosagem , Ivermectina/uso terapêutico , Infecções por Nematoides/tratamento farmacológico , Contagem de Ovos de Parasitas/veterinária , Ratos , Ratos Sprague-Dawley , Doenças dos Roedores/tratamento farmacológicoRESUMO
An expedition across the Asian part of the Black Sea coast and national parks of Northern Turkey was organized in the summer of 2001 to investigate the presence of Borrelia burgdorferi sensu lato (s.l.), Lyme borreliosis agent, and Anaplasma phagocytophilum, human granulocytic ehrlichiosis, agent, in wild mice. A total of 65 Apodemus flavicollis, Apodemus sylvaticus, Microtus epiroticus, Crocidura suaveolens and Mus macedonicus, were captured. Two out of 22 Apodemus sylvaticus specimens were seropositive for B. afzelii by enzyme-linked immunosorbent assay as confirmed by Western blotting, however cultures of skin and bladder samples from all small mammals in Barbour-Stoenner-Kelly's medium-II remained negative for B. burgdorferi s.l. All sera tested were negative for Anaplasma phagocytophilum by indirect immunofluorescent assay. The prevalence of B. burgdorferi s.l. and Anaplasma phagocytophilum is low in wild mice of the Asian part of Northern Turkey.
