RESUMO
Coordination of cardiovascular and respiratory systems enables a wide range of human adaptation and depends upon the functional state of an individual organism. Hypoxia is known to elicit changes in oxygen and carbon dioxide sensitivity, while training alters cardiorespiratory coordination (CRC). The delayed effect of high altitude (HA) acclimatization on CRC in mountaineers remains unknown. The objective of this study was to compare CRC in acute hypercapnia in mountaineers before and after a HA expedition. Nine trained male mountaineers were investigated at sea level before (Pre-HA) and after a 20-day sojourn at altitudes of 4,000-7,000 m (Post-HA) in three states (Baseline, Hypercapnic Rebreathing, and Recovery). A principal component (PC) analysis was performed to evaluate the CRC. The number of mountaineers with one PC increased Post-HA (nine out of nine), compared to Pre-HA (five out of nine) [Chi-square (df = 1) = 5.14, P = 0.023]; the percentage of total variance explained by PC1 increased [Pre-HA median 65.6 (Q1 64.9/Q3 74.9), Post-HA 75.6 (73.3/77.9), P = 0.028]. Post-HA, the loadings of the expired fraction of O2, CO2, and ventilation onto PC1 did not change, and the loading of heart rate increased [Pre-HA 0.64 (0.45/0.68) and Post-HA 0.76 (0.65/0.82), P = 0.038]. During the Recovery, the percentage of total variance explained by PC1 was higher than during the Baseline. Post-HA, there was a high correlation between the Exercise addiction scores and the eigenvalues of PC1 (r = 0.9, P = 0.001). Thus, acute hypercapnic exposure reveals the Post-HA increase in cardiorespiratory coordination, which is highly related to the level of exercise addiction.
RESUMO
Understanding the mechanisms of oxygen supply regulation, which involves the respiratory and cardiovascular systems, during human adaptation to intense physical activity, accompanied by hypoxemia, is important for the management of a training process. The objectives of this study were to investigate the cardiorespiratory coherence (CRC) changes in the low-frequency band in response to hypoxic exposure and to verify a dependence of these changes upon sports qualification level in athletes. Twenty male runners aged 17-25 years were exposed to acute normobaric hypoxia (10% O2) for 10 min. Respiration, gas exchange, and heart rate were measured at baseline, during hypoxia, and after the exposure. To evaluate cardiorespiratory coupling, squared coherence was calculated based on 5-s averaged time series of heart and respiratory rhythms. Based on sports qualification level achieved over 4 years after the experimental testing, athletes were retrospectively divided into two groups, one high level (HLG, n = 10) and the other middle level (MLG, n = 10). No differences in anthropometric traits were observed between the groups. In the pooled group, acute hypoxia significantly increased CRC at frequencies 0.030-0.045 Hz and 0.075 Hz. In response to hypoxia, oxygen consumption decreased in HLG, and carbon dioxide production and ventilation increased in MLG. At 0.070-0.080 Hz frequencies in hypoxia, the CRC in HLG was higher than in MLG. Thus, highly qualified athletes enhance intersystem integration in response to hypoxia. This finding can be a physiological sign for the prognosis of qualification level in runners.
