[Athletic activities and prevention of vascular risk factors]. / Activités sportives et prévention des facteurs de risque vasculaire.

Vascular accidents represent one of the most important causes of morbidity and mortality in France at the present time, and factors increasing the risk of such lesions are well documented: hypertension, smoking, and metabolic disorders (lipids, glucides, uric acid). Though genetic factors are definitely involved, most of them are acquired and related to our way of life, our type of civilisation, and, more particularly, to overeating and a sedentary life. Regular physical exercise of sufficient degree can considerably reduce the various factors which increase risk and, at the same time, diminish the frequency of these very serious vascular accidents.

[Hypotensive effects of timolol in 86 patients (author's transl)]. / Effets antihypertenseurs du maléate de timolol. A propos de 86 observations.

Antihypertensive action of timolol (MK 950) was studied in 86 outpatients with essential, uncomplicated hypertension. Timolol is an effective hypotensive drug with significant lowering pressor effect. Timolol was given alone in 53 cases and in association with other hypotensive drugs in 33 cases: the mean dose was 20 mg daily for 8 months. At the end of treatment the mean diastolic pressure recumbert, standing, and after exercise had decreased by 10.2, 9.2 and 11 mmHg. Cardiac frequency had decreased by 13, 24 and 29 p. min lying, standing and after exercise. Side effects were rare, with cessation of treatment only in 4 cases.