RESUMO
Rhinoscleroma is a chronic disease of the respiratory system. Its onset is insidious and its symptoms are often nonspecific. Yet rhinoscleroma is a progressive disease that can lead to significant disability. The proper diagnosis is difficult because of the nonspecific presentation and rarity of rhinoscleroma. Biopsy tissue often is not properly cultured. Diagnostic histologic features may not be readily apparent or may be overlooked by the unsuspecting pathologist. A case of rhinoscleroma is reported in which an immunoperoxidase technique was applied to retrospectively confirm the diagnosis. The usefulness of this new technique in the diagnosis of rhinoscleroma is discussed.
Assuntos
Técnicas Imunoenzimáticas , Klebsiella pneumoniae/imunologia , Klebsiella/imunologia , Rinoscleroma/diagnóstico , Adulto , Anticorpos Antibacterianos/isolamento & purificação , Diagnóstico Diferencial , Feminino , Humanos , Klebsiella pneumoniae/isolamento & purificação , Pólipos Nasais/diagnóstico , Rinoscleroma/microbiologiaRESUMO
Malignant hyperthermia (MH) is a chemically induced, genetic myopathy characterized by metabolic and respiratory acidosis, arrhythmias, hyperpyrexia, and muscular rigidity usually occurring during or within 24 hours postanesthesia. It is initiated by some anesthetic drugs, muscle relaxants, and possibly by catecholamines produced by stress. The incidence of the disease is 1:15,000 in populations who have received a general anesthetic. A recently developed platelet bioassay test allows for rapid identification of the susceptible individual, while medication with dantrolene sodium can usually prevent or reverse the syndrome.