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1.
Clin Neurol Neurosurg ; 222: 107470, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36265244

RESUMO

OBJECTIVE: Currarino Syndrome (CS) is a rare autosomal dominant genetic disorder that is defined by a triad of: presacral mass, anorectal malformations, and sacral bone dysplasia. Once discovered, these lesions are often surgically treated to avoid life threatening complications such as meningitis and malignant transformation of a sacral teratoma. As this syndrome is usually diagnosed in childhood, accurate diagnosis in adults presenting with this syndrome can be challenging and delay treatment. We present a case report with diagnostic and surgical management strategies of CS presenting in an elderly patient with accompanying review of literature. METHODS: We performed a literature review by searching PubMed, Ovid Embase, and Scopus electronic databases with the predetermined inclusion criteria of cases of CS in the adult population. RESULTS: A 70-year-old male with newly diagnosed CS and meningitis successfully underwent resection of his lesion as an interdisciplinary case between neurosurgery and colorectal surgery. At six-month follow up, the patient reports resolution of constipation and urinary symptoms, no longer has signs of infection, and remains neurologically full strength in his lower extremities. A review of literature revealed only 5 previously reported cases of CS presenting in the adult population with 3 of these cases requiring surgical intervention. CONCLUSION: Currarino Syndrome (CS) is an autosomal dominant genetic disorder characterized by a presacral mass, sacral bony deformities, and anorectal malformations. It is usually diagnosed in pediatric age group. In this article, we present a case of a 70-year-old male presenting with meningitis, encephalopathy, and gastrointestinal disturbances.


Assuntos
Malformações Anorretais , Anormalidades do Sistema Digestório , Meningite , Doenças da Coluna Vertebral , Masculino , Adulto , Humanos , Criança , Idoso , Anormalidades do Sistema Digestório/complicações , Anormalidades do Sistema Digestório/diagnóstico , Anormalidades do Sistema Digestório/cirurgia , Canal Anal/cirurgia , Canal Anal/anormalidades , Sacro/cirurgia
2.
World Neurosurg ; 161: e61-e74, 2022 05.
Artigo em Inglês | MEDLINE | ID: mdl-35032716

RESUMO

BACKGROUND: Glioblastoma (GB) is an aggressive tumor showing extensive intertumoral and intratumoral heterogeneity. Several possible reasons contribute to the historical inability to develop effective therapeutic strategies for treatment of GB. One such challenge is the inability to consistently procure high-quality biologically preserved specimens for use in molecular research and patient-derived xenograft model development. No scientifically derived standardized method exists for intraoperative tissue collection specifically designed with the fragility of RNA in mind. METHODS: In this investigation, we set out to characterize matched specimens from 6 GB patients comparing the traditional handling and collection processes of intraoperative tissue used in most neurosurgical operating rooms versus an automated resection, collection, and biological preservation system (APS) which captures, preserves, and biologically maintains tissue in a prescribed and controlled microenvironment. Matched specimens were processed in parallel at various time points and temperatures, evaluating viability, RNA and protein concentrations, and isolation of GB cell lines. RESULTS: We found that APS-derived GB slices stored in an APS modified medium remained viable and maintained high-quality RNA and protein concentration for up to 24 hours. CONCLUSIONS: Our results showed that primary GB cell cultures derived in this manner had improved growth over widely used collection and preservation methods. By implementing an automated intraoperative system, we also eliminated inconsistencies in methodology of tissue collection, handling and biological preservation, establishing a repeatable and standardized practice that does not require additional staff or a laboratory technician to manage it.


Assuntos
Neoplasias Encefálicas , Glioblastoma , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/cirurgia , Glioblastoma/patologia , Glioblastoma/cirurgia , Humanos , Projetos Piloto , Preservação Biológica , RNA , Preservação de Tecido/métodos , Microambiente Tumoral
4.
J Neurointerv Surg ; 13(1): 91-95, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32487766

RESUMO

BACKGROUND: Currently, there are no large-scale studies in the neurointerventional literature comparing safety between transradial (TRA) and transfemoral (TFA) approaches for flow diversion procedures. This study aims to assess complication rates in a large multicenter registry for TRA versus TFA flow diversion. METHODS: We retrospectively analyzed flow diversion cases for cerebral aneurysms from 14 institutions from 2010 to 2019. Pooled analysis of proportions was calculated using weighted analysis with 95% CI to account for results from multiple centers. Access site complication rate and overall complication rate were compared between the two approaches. RESULTS: A total of 2,285 patients who underwent flow diversion were analyzed, with 134 (5.86%) treated with TRA and 2151 (94.14%) via TFA. The two groups shared similar patient and aneurysm characteristics. Crossover from TRA to TFA was documented in 12 (8.63%) patients. There were no access site complications in the TRA group. There was a significantly higher access site complication rate in the TFA cohort as compared with TRA (2.48%, 95% CI 2.40% to 2.57%, vs 0%; p=0.039). One death resulted from a femoral access site complication. The overall complications rate was also higher in the TFA group (9.02%, 95% CI 8.15% to 9.89%) compared with the TRA group (3.73%, 95% CI 3.13% to 4.28%; p=0.035). CONCLUSION: TRA may be a safer approach for flow diversion to treat cerebral aneurysms at a wide range of locations. Both access site complication rate and overall complication rate were lower for TRA flow diversion compared with TFA in this large series.


Assuntos
Procedimentos Endovasculares/tendências , Artéria Femoral/cirurgia , Aneurisma Intracraniano/cirurgia , Complicações Pós-Operatórias , Artéria Radial/cirurgia , Stents Metálicos Autoexpansíveis/tendências , Adulto , Idoso , Cateterismo Periférico/efeitos adversos , Cateterismo Periférico/métodos , Cateterismo Periférico/tendências , Estudos de Coortes , Procedimentos Endovasculares/efeitos adversos , Procedimentos Endovasculares/métodos , Feminino , Artéria Femoral/diagnóstico por imagem , Humanos , Aneurisma Intracraniano/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/diagnóstico por imagem , Complicações Pós-Operatórias/etiologia , Artéria Radial/diagnóstico por imagem , Sistema de Registros , Estudos Retrospectivos , Stents Metálicos Autoexpansíveis/efeitos adversos , Fatores de Tempo , Resultado do Tratamento
5.
World Neurosurg ; 147: 130-143, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33307257

RESUMO

The Society of Neurological Surgeons (SNS), founded in 1920, is one of the oldest neurosurgical society in the world. The founding members were prominent surgeons that met with the idea of furthering the field of neurosurgery. Initial meetings were forums to observe and discuss new surgeries. During the first 6 meetings of the SNS, surgical cases from the areas of cranial trauma, epilepsy, spinal cord tumors, brain tumors, pituitary tumor, trigeminal neuralgia, and cerebellar tumors were discussed. Publications from the members during that time included articles on the use of intracranial hypertonic saline, trigeminal neuralgia, brachial plexus injuries, management of head injury, spinal cord tumors, cervical spine trauma, and intracranial hemorrhage in the newborn. The members also invited lecturers from other specialties, such as neurology, ophthalmology, radiology, and pathology, typifying the interdisciplinary nature of neurosurgical practice. The meetings served as a forum to build consensus on neurosurgical treatment methods. Cases that ultimately changed the practice of neurosurgery at that time will be profiled. The SNS began as a traveling club of neurosurgical leaders who learned from each other's clinical experience to mold this burgeoning new field. However, the members made an impact on how neurosurgery was practiced nationally.


Assuntos
Neurocirurgia/história , Sociedades Médicas/história , Congressos como Assunto/história , História do Século XX , Humanos , Estados Unidos
6.
Neurol India ; 68(6): 1301-1306, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33342857

RESUMO

BACKGROUND: Aneurysms arising in relation to perforators of the basilar artery (basilar perforator aneurysms or BPA) are very rare. Prior literature indicates the need for typically more than one angiogram for diagnosis, and argues for the utility of delayed angiograms in cases of subarachnoid hemorrhage (SAH) with initial negative studies. Different treatment modalities for BPA including endovascular, microsurgical, and conservative management have been described. Contemporary management appears to favor endovascular therapy. We discuss the topic by presenting a case which represents the first instance of BPA diagnosis after a fourth angiogram and subsequent successful endovascular occlusion. A literature review is provided. OBJECTIVE: To discuss the unique presentation and management dilemmas in the rare entity of basilar artery perforator aneurysms by presentation of a case that was managed successfully by endovascular means. We also indirectly highlight the need for multiple follow-up angiograms in initial angiographically negative subarachnoid hemorrhage. METHODS AND MATERIALS: We describe a 62-year-old male presenting with good clinical grade SAH and three negative angiograms, whose hospital course was complicated by repeat intraventricular hemorrhage. A fourth angiogram revealed a BPA. Multiple overlapping stents placed in the basilar artery achieved successful aneurysm exclusion. A comprehensive review of the literature was performed on PubMed. RESULTS AND CONCLUSIONS: Only 57 cases of BPAs have been described in literature. Multiple angiograms may be necessary for diagnosis. These aneurysms present with SAH. Endovascular flow modification is the current treatment of choice by means of overlapping stents or flow diversion.


Assuntos
Aneurisma Roto , Embolização Terapêutica , Aneurisma Intracraniano , Hemorragia Subaracnóidea , Aneurisma Roto/terapia , Artéria Basilar/diagnóstico por imagem , Angiografia Cerebral , Humanos , Aneurisma Intracraniano/diagnóstico por imagem , Aneurisma Intracraniano/cirurgia , Masculino , Pessoa de Meia-Idade , Stents , Hemorragia Subaracnóidea/diagnóstico por imagem , Hemorragia Subaracnóidea/etiologia , Hemorragia Subaracnóidea/cirurgia , Resultado do Tratamento
7.
Spine (Phila Pa 1976) ; 45(9): 599-604, 2020 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-31770321

RESUMO

MINI: This retrospective case series investigated paraspinous flaps for coverage of complex spinal wounds. 6.90% of patients developed postoperative wound infections and 0.00% of patients required instrumentation removal for infection. This suggests that these flaps may offer a long-term solution in wound management for patients with repeated spinal operations. STUDY DESIGN: Retrospective case series. OBJECTIVE: To investigate the efficacy and complication profile of the use of paraspinous muscle flaps for closure of complex spinal wounds. SUMMARY OF BACKGROUND DATA: Paraspinous muscle flap closure offers an innovative option in difficult-to-manage post-spinal surgery wounds. Current literature reports are mixed in terms of success and complication rates of these flap procedures, with most sources citing a wound complication rate of 20%. METHODS: This case series investigated the hospital course of 58 patients undergoing paraspinous flap closure after spinal surgery between the years 2014 and 2018. Information gathered includes: demographics, surgery indication, location, and length of incision on the spine, nutrition labs, previous spinal surgeries, preoperative wound class, operative times, length of hospital stay, and complication rates including reoperation, wound infection, and other postoperative complications. RESULTS: Of the 58 patients undergoing spinal muscle flap closure, 51 (87.93%) had undergone previous spinal surgery with an average of 2.12 previous surgeries in these patients. Mean albumin and prealbumin were 2.62 and 13.75, respectively. 4/58 (6.90%) developed a wound infection or experienced a continuation of their chronic osteomyelitis. Of the 57 patients that had spinal instrumentation, three (5.26%) had spinal implants removed at the time of surgery and two (3.51%) had it removed or replaced later for mechanical complications. No patients had instrumentation removed for chronic infections. One (1.72%) experienced reoperation for wound-related complications. These rates are lower than most complication rates in the current literature. CONCLUSION: The plastic and reconstructive paraspinous muscle flap has promising results as a closure option for complex spinal wounds following neurosurgical cases. Further investigation is called for to determine the applicability of these results to the general population. LEVEL OF EVIDENCE: 4.


Retrospective case series. To investigate the efficacy and complication profile of the use of paraspinous muscle flaps for closure of complex spinal wounds. Paraspinous muscle flap closure offers an innovative option in difficult-to-manage post-spinal surgery wounds. Current literature reports are mixed in terms of success and complication rates of these flap procedures, with most sources citing a wound complication rate of 20%. This case series investigated the hospital course of 58 patients undergoing paraspinous flap closure after spinal surgery between the years 2014 and 2018. Information gathered includes: demographics, surgery indication, location, and length of incision on the spine, nutrition labs, previous spinal surgeries, preoperative wound class, operative times, length of hospital stay, and complication rates including reoperation, wound infection, and other postoperative complications. Of the 58 patients undergoing spinal muscle flap closure, 51 (87.93%) had undergone previous spinal surgery with an average of 2.12 previous surgeries in these patients. Mean albumin and prealbumin were 2.62 and 13.75, respectively. 4/58 (6.90%) developed a wound infection or experienced a continuation of their chronic osteomyelitis. Of the 57 patients that had spinal instrumentation, three (5.26%) had spinal implants removed at the time of surgery and two (3.51%) had it removed or replaced later for mechanical complications. No patients had instrumentation removed for chronic infections. One (1.72%) experienced reoperation for wound-related complications. These rates are lower than most complication rates in the current literature. The plastic and reconstructive paraspinous muscle flap has promising results as a closure option for complex spinal wounds following neurosurgical cases. Further investigation is called for to determine the applicability of these results to the general population. Level of Evidence: 4.


Assuntos
Músculos Paraespinais/transplante , Procedimentos de Cirurgia Plástica/métodos , Doenças da Coluna Vertebral/cirurgia , Retalhos Cirúrgicos/transplante , Ferida Cirúrgica/cirurgia , Adulto , Idoso , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos/efeitos adversos , Reoperação/efeitos adversos , Estudos Retrospectivos , Doenças da Coluna Vertebral/diagnóstico , Doenças da Coluna Vertebral/etiologia , Ferida Cirúrgica/diagnóstico , Ferida Cirúrgica/etiologia , Infecção da Ferida Cirúrgica/diagnóstico , Infecção da Ferida Cirúrgica/etiologia , Infecção da Ferida Cirúrgica/cirurgia , Resultado do Tratamento
8.
Surg Neurol Int ; 10: 12, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30783543

RESUMO

BACKGROUND: Neurofibromatosis is an autosomal dominant disorder of the nerves, resulting in café-au-lait spots, axillary freckling, macules, and neurofibromas throughout the nervous system. Diagnosis of this condition has in the past been mainly clinical, but the usage of magnetic resonance imaging neurography (MRN) is a new diagnostic modality. Here, we report on a case of neurofibromatosis type I (NF-1) that was diagnosed using MRN after a protracted clinical course. CASE DESCRIPTION: A 23-year-old female presented with several months of worsening right upper and lower quadrant abdominal pain. The patient underwent computed tomography (CT) of the abdomen and pelvis demonstrating multiple neurofibromas involving the psoas muscle and mesentery of the lower abdomen. Subsequent total neuronal axis magnetic resonance imaging (MRI) using the neurography protocol (MRN) showed multiple neurofibromas in both the right brachial plexus and lumbar plexus. CONCLUSION: We present a case of NF-1 that was diagnosed using MRN following a protracted clinical course. MRN is a diagnostic modality for NF-1 and other peripheral nerve disorders.

9.
World Neurosurg ; 122: 331-341, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30415042

RESUMO

INTRODUCTION: Magnetic resonance neurography (MRN) is a newer imaging technique that is increasingly used for detailed visualization of peripheral nerves not reliably achieved with conventional imaging modalities. Although MRN has been previously characterized in the literature, few studies have assessed its utility to neurosurgery, where there is potentially substantial impact particularly with preoperative assessment. In this article, we performed a retrospective review of cases in which MRN was used for clinical evaluation and surgical decision making. METHODS: MRN, clinical assessment, and operative decision making were retrospectively assessed in 206 consecutive patients at our institution between 2015 and 2018. RESULTS: MRN was determined to lead to a change in diagnosis or surgical decision making in 44 patients (21.4%: 27 female, 17 male). These were classified into 6 major diagnostic categories: trauma, postsurgical evaluation, compressive/degenerative conditions, tumors, neuritis/inflammation, and other neurogenic lesions. Nine representative cases were selected from these categories to highlight the range of neurosurgical pathologies in which MRN was useful in diagnostic assessment and surgical decision making. CONCLUSIONS: MRN is an underused resource with great potential value in the diagnoses, surgical planning, and postoperative assessment of various neurosurgical conditions. These present incremental utility to the neurosurgeon as well as socioeconomic benefit in the detection of potentially surgically treatable lesions.


Assuntos
Imageamento por Ressonância Magnética/métodos , Doenças do Sistema Nervoso Periférico/diagnóstico , Neuropatias do Plexo Braquial/diagnóstico , Neuropatias do Plexo Braquial/cirurgia , Tomada de Decisão Clínica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias de Bainha Neural/diagnóstico , Neoplasias de Bainha Neural/cirurgia , Procedimentos Neurocirúrgicos/métodos , Planejamento de Assistência ao Paciente , Doenças do Sistema Nervoso Periférico/cirurgia , Estudos Retrospectivos , Neoplasias da Medula Espinal/diagnóstico , Neoplasias da Medula Espinal/cirurgia
10.
World Neurosurg ; 116: 362-369, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29883815

RESUMO

BACKGROUND: Sacral tumors present a significant challenge to the spine surgeon. As new techniques have evolved in recent years, these lesions have become more amenable to aggressive surgical treatment. Although sacral tumors make up only a small minority of spinal tumors, their surgical management warrants special consideration. METHODS: Based on our experience, we highlight 3 important surgical nuances specifically for the treatment of sacral tumors: preservation and maximization of neurologic function, protection of ventral abdominal and pelvic structures, and lumbopelvic fixation. RESULTS: Two cases of patients with sacral tumors treated at our institution are presented to illustrate these points. Both patients had successful postoperative courses, and remained pain free, well-fixated, and neurologically intact at 3-4 month follow-up. They had no evidence of biomechanical instability. CONCLUSIONS: To ensure a successful outcome, a goal-directed, methodical approach is required.


Assuntos
Vértebras Lombares/cirurgia , Procedimentos Ortopédicos , Sacro/cirurgia , Neoplasias da Coluna Vertebral/cirurgia , Idoso , Biópsia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Ortopédicos/métodos , Sacro/diagnóstico por imagem , Sacro/patologia , Neoplasias da Coluna Vertebral/diagnóstico , Resultado do Tratamento
11.
Neurosurg Focus ; 44(VideoSuppl1): V5, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29291290

RESUMO

In this video, the authors demonstrate a minimally invasive approach and resection of a paraspinal schwannoma. Using an expandable retractor, the authors were able to identify important adjacent bony landmarks and hence visualize and remove this peripheral nerve sheath tumor. While a tubular retractor is commonly used for interbody fusion procedures, the location of the tumor allowed this minimally invasive approach resulting in excellent access, minimal soft-tissue injury, and a short hospital stay. The authors present this approach as a less invasive and yet effective technique for resection of otherwise difficult-to-access nerve lesions. The video can be found here: https://youtu.be/89OY5wdMB_k .


Assuntos
Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Neurilemoma/diagnóstico por imagem , Neurilemoma/cirurgia , Músculos Paraespinais/diagnóstico por imagem , Músculos Paraespinais/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Vértebras Torácicas/diagnóstico por imagem , Vértebras Torácicas/cirurgia
12.
World Neurosurg ; 109: 275-284, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29017982

RESUMO

OBJECTIVE: Spontaneous cervical intradural disc herniation (IDH) is a rare occurrence with limited and disparate information available regarding its presentation, diagnosis, and treatment. However, its accurate detection is vital for planning surgical treatment. In this review of the literature, we collected data from all cervical IDHs described to date. Particular attention was paid to diagnostic findings, surgical approach, and causation for cervical IDH, especially at the cervicothoracic junction. METHODS: A review for cases of cervical IDH was performed via the following search criteria: ("neck"[MeSH Terms] OR "neck"[All Fields] OR "cervical"[All Fields]) AND intradural[All Fields] AND disc[All Fields]. Thirty-seven cases of cervical disc herniation were identified. Demographic variables identified included age, sex, cervical level of herniation, history of associated cervical trauma, presence of Brown-Séquard syndrome, Horner syndrome, and other neurologic findings, radiographic findings, direction of surgical approach, and postoperative outcomes. RESULTS: A total of 37 cases of cervical IDH were identified. Most of the cases occurred at the lower levels of the cervical spine, with 35.1% at the C5-C6 level, followed by 24.3% at C6-C7, and lower still at other levels. Of the patients reviewed, 44.4% had a previous history of trauma before manifestation of symptom, with the majority being spontaneous IDH with no previous history of trauma or spine surgery. Brown-Séquard syndrome was present in 43.2% of the patients, whereas 10.8% of patients experienced Horner syndrome. The most common presentations of IDH included quadriplegia, finger/gait ataxia, radiculopathy, and nuchal pain. The degree of neurologic recovery was not associated with patient age. Most of the cervical IDHs in the literature were treated surgically via an anterior approach, but a larger portion of patients who underwent a posterior approach had improved recovery. CONCLUSIONS: Cervical IDH is a rare event, with this review of the literature outlining the clinical and radiographic parameters of its presentation as well as comparing common surgical strategies for treatment. We outline theories underlying the development of cervical IDH and argue for a posterior surgical approach in which the disc herniation is sequestrated with migration.


Assuntos
Vértebras Cervicais/diagnóstico por imagem , Vértebras Cervicais/cirurgia , Deslocamento do Disco Intervertebral/diagnóstico , Deslocamento do Disco Intervertebral/cirurgia , Humanos , Deslocamento do Disco Intervertebral/diagnóstico por imagem , Fusão Vertebral , Tomografia Computadorizada por Raios X
13.
Surg Neurol Int ; 8: 77, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28584680

RESUMO

BACKGROUND: Currarino syndrome (CS) is a rare genetic condition that presents with the defining triad of anorectal malformations, sacral bone deformations, and presacral masses, which may include teratoma. Neurosurgeons are involved in the surgical treatment of anterior meningoceles, which are often associated with this condition. The accepted surgical treatment is a staged anterior-posterior resection of the presacral mass and obliteration of the anterior meningocele. CASE DESCRIPTION: This case involved a 36-year-old female who presented with late onset of symptoms attributed to CS (e.g., presacral mass, anterior sacral meningocele, and sacral agenesis). She successfully underwent multidisciplinary single-stage approach for treatment of the anterior sacral meningocele and resection of the presacral mass. This required obliteration of the meningocele and closure of the dural defect. One year later, her meningocele had fully resolved. CONCLUSION: While late presentations with CS are rare, early detection and multidisciplinary treatment including single-state anterior may be successful for managing these patients.

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