Behavioral, familial and comorbid illness risk factors of colorectal cancer: a case control study

Introduction: Though colorectal cancer is a disease of public health importance, there is little evidence about risk factors of colorectal cancer in South Asians. Objectives: We aimed to determine the behavioral, familial and comorbid illness risk factors for colorectal cancer among Sri Lankan adults. Methods: We conducted this study among 325 participants (65 incident colorectal cancer cases, 130 hospital and 130 community controls) in five major health care institutions and communities in areas with high incidence in Sri Lanka. Behavioral, genetic and comorbid risk factors were assessed through an interviewer administered questionnaire. Risk factors were evaluated using bivariate and multivariate logistic regression. Results: Adjusted logistic regression showed that frequent consumption of red meat (OR 3.06, 95% CI 1.26-7.43) and deep fried food (OR 2.54, 95% CI 1.22-5.39), hypertension ≥ 10 years (OR 3.3, 95% CI 1.3-8.6), colorectal cancer (OR 4.91, 95% CI 1.70-14.18) and other cancers (OR 3.0, 95% CI 1.14-7.81) among first degree relatives and age >50 years (OR 2.6, 95% CI 1.1 to 5.9) were significant risk factors compared to hospital controls. Frequent consumption of deep fried food (OR 4.2, 95% CI 1.7-10.1), being an ever smoker (OR 3.2, 95% CI 1.1-9.3), a current or former drinker (OR 5.4, 95% CI 1.1-27.8) and hypertension ≥ 10 (OR 5.1, 95% CI 1.7-15.6) were risk factors compared to community controls. Conclusion: The behavioral, familial and comorbid illness risk factors identified should be considered in designing preventive strategies and identifying high-risk individuals for screening for colorectal cancer.

Beyond survival: 5-year neurodevelopmental follow-up of a cohort of preterm infants in Colombo, Sri Lanka.

BACKGROUND: There is a lack of information on long-term neurodevelopmental outcome in preterm neonates in low- and middle-income countries. OBJECTIVES: To describe the developmental attainments of preterm neonates followed up for 5 years and to identify the risk factors for impairment. METHOD: A prospective descriptive cohort study was undertaken in neonates of 34 weeks gestation born within a period of 12 months at a single tertiary maternity and neonatal unit in Colombo, Sri Lanka. Infants were assessed for neurodevelopment using the Bayley Infant and Toddler III® Assessments at 6, 12 and 24 months of corrected age and school readiness assessment at 5 years. RESULTS: Fifty-one infants were assessed at least once, 45 were assessed at 2 years and 39 had a final assessment at 5 years. Neurodevelopmental attainment deteriorated significantly in the cognitive and motor composite scores from 6 to 24 months (p < 0.05). By 5 years the number of children with delay in cognitive, language and motor domains had reduced significantly from 24 months (p < 0.05) but the cognitive skills remained most affected (10/39). At 5 years, 13 of 39 children had a confirmed diagnosis of a neurodevelopmental disorder: eight had attention deficit hyperactivity disorder, three autism spectrum disorder, one cerebral palsy and one visual impairment. Surfactant administration and retinopathy of prematurity were the most significant risks for delayed development at 5 years (p < 0.05). CONCLUSION: Deterioration of cognitive and motor composite scores over the first 24 months highlights the need for regular surveillance of premature infants. There was a discrepancy between the diagnosis of neurodevelopmental delay at 24 months and at 5 years. But the notable impact on school readiness skills requires public health initiatives to cater for the needs of these children.

Out-of-pocket expenditure in accessing healthcare services among Chronic Kidney Disease patients in Anuradhapura District

Introduction: Chronic Kidney Disease (CKD) has significant economic impact on both patients' households and the country. Objectives: To assess the out-of-pocket (OOP) expenditure of accessing health services among CKD patients in Anuradhapura District Methods: This community based cross-sectional study included a representative sample of 1174 registered CKD patients from all 19 Medical Officer of Health areas in the District of Anuradhapura. Trained para-medical staff visited the households and administered an interviewer administered questionnaire to gather information. Results: A total of 1118 CKD patients participated. Mean age was 58.3 (SD 10.8) years. Fifty nine (5.3%) patients had been hospitalized during the six months preceding data collection. The total OOP for a hospital admission for one patient was Rs. 3625 (IQR 1650-8760). Thirty eight (3.4%) patients were on dialysis. The median direct cost per patient for an episode of dialysis was Rs.595 (IQR 415-995) while the median direct cost for a dialysis patient per month was Rs.5490 (IQR 3950-10934). In the study population a total of 1095 (98.0%) had attended clinic at least once during the six months preceding the study. The OOP expenditure for a single clinic visit for one patient was Rs.434 (IQR 200- 860). Conclusions: CKD patients living in the Anuradhapura District spent significant amounts on accessing health care which can worsen their economic hardships. Planned interventions are warranted in order to improve their quality of life and financial situation.

Knowledge, attitudes and practices regarding handling mercury containing medical devices among nurses in a tertiary care paediatric hospital in Sri Lanka.

BACKGROUND: Mercury is a highly toxic heavy metal used in many medical devices in the healthcare sector, making nurses one of the vulnerable occupational groups. OBJECTIVE: To assess knowledge, attitudes and practices regarding handling mercury containing devices and factors associated with knowledge among nurses in a paediatric hospital in Sri Lanka. METHODS: A descriptive cross-sectional study was conducted among nurses (n = 538) working in Lady Ridgeway Hospital, Sri Lanka. Information on the use of mercury containing medical devices, accidental exposure, management of spillage and disposal was gathered using a self-administered questionnaire. RESULTS: A total of 472 nurses responded with a response rate of 87.7%. Of the 347 mercury thermometer users, 67.1% had experienced breakages while among 405 mercury sphygmomanometer users, 20.0% had experienced mercury spillages, during a three months period prior to the study. A majority (56.8%) had 'good' overall knowledge regarding mercury and its adverse effects while 94.1% had favorable attitudes towards protecting themselves/others from mercury. Practices related to managing a mercury spill were poor. Work experience >10 years (p = 0.032) and favorable attitude (p = 0.007) were associated with good knowledge while having a training on managing a mercury spillage was not (p = 0.850). CONCLUSIONS: Gaps in practices on managing a mercury spillage were evident. Current training programmes were not found to be effective.