Constructing Asymmetric Polyion Complex Vesicles via Template Assembling Strategy: Formulation Control and Tunable Permeability.

A strategy for constructing polyion complex vesicles (PICsomes) with asymmetric structure is described. Poly(methylacrylic acid)-block-poly(N-isopropylacrylamide) modified gold nanoparticles (PMAA-b-PNIPAm-@-Au NPs) were prepared and then assembled with poly(ethylene glycol)-block-poly[1-methyl-3-(2-methacryloyloxy propylimidazolium bromine)] (PEG-b-PMMPImB) via polyion complex of PMMA and PMMPImB. After removing the Au NPs template, asymmetric PICsomes composed of a PNIPAm inner-shell, PIC wall, and PEG outer-corona were obtained. These PICsomes have low protein absorption and thermally tunable permeability, provided by the PEG outer-corona and the PNIPAm inner-shell, respectively. Moreover, PICsome size can be tailored by using templates of predetermined sizes. This novel strategy for constructing asymmetric PICsomes with well-defined properties and controllable size is valuable for applications such as drug delivery, catalysis and monitoring of chemical reactions, and biomimetics.

(E)-N'-(4-Meth-oxy-benzyl-idene)-3-nitro-benzohydrazide.

In the title compound, C(15)H(13)N(3)O(4), the two substituted benzene rings form a dihedral angle of 5.0 (3)°. In the crystal, inter-molecular N-H⋯O hydrogen bonds link mol-ecules into chains along the b axis.

(E)-N'-(2-Meth-oxy-benzyl-idene)-3-nitro-benzohydrazide.

In the title compound, C(15)H(13)N(3)O(4), the two substituted benzene rings form a dihedral angle of 10.9 (3)°. In the crystal, inter-molecular C-H⋯O and N-H⋯O hydrogen bonds link mol-ecules into chains running parallel to [101].