RESUMO
Prostate cancer (PCa) is the most commonly diagnosed cancer in males worldwide. MicroRNAs (miRNAs/miRs) are small noncoding RNAs that participate in the regulation of various biological processes by regulating posttranscriptional gene expression. However, whether dysregulation of miRNA expression may be associated with the carcinogenesis of PCa remains to be elucidated. The present study identified differentially expressed miRNAs in PCa by analyzing two publicly available gene expression datasets, GSE14857 and GSE21036. The results demonstrated that miR5123p was significantly upregulated in PCa. Furthermore, the present study explored the molecular functions of miR5123p in PCa, and demonstrated that overexpression of miR5123p promoted PCa cell proliferation and reduced G1 phase cell cycle arrest in PCa. These results indicated that miR5123p may act as an oncogene in PCa. To the best of our knowledge, this is the first study revealed the molecular functions of miR5123p in PCa. To obtain valuable insights into the potential mechanisms of miR5123p, bioinformatics analyses were performed to identify the targets of miR5123p. Kyoto Encyclopedia of Genes and Genomes pathway and Gene Ontology category analyses revealed that miR5123p may be associated with the mitogenactivated protein kinase signaling pathway and numerous biological processes, including cell adhesion, cell proliferation, cell cycle and apoptosis. These results suggested that miR5123p may be considered a potential diagnostic and therapeutic target of PCa.
Assuntos
Ciclo Celular/genética , MicroRNAs/genética , Neoplasias da Próstata/genética , Interferência de RNA , Linhagem Celular Tumoral , Proliferação de Células , Biologia Computacional/métodos , Pontos de Checagem da Fase G1 do Ciclo Celular/genética , Expressão Gênica , Perfilação da Expressão Gênica , Regulação Neoplásica da Expressão Gênica , Ontologia Genética , Humanos , Masculino , Neoplasias da Próstata/metabolismo , Transdução de SinaisRESUMO
Bronchogenic cyst is a relatively rare abnormality that develop from the accessory lung buds of the foregut. The cyst is regarded as a congenital developmental abnormality. Occurence in the retroperitoneal presentation is rare. Here, we present two patients who had an incidentally discovered retroperitoneal mass which were revealed to be bronchogenic cysts after surgical extirpation.
