RESUMO
Background: Cancers arising in the oral cavity are more commonly of squamous cell carcinomas. E-cadherin is a calcium-dependant transmembrane glycoprotein of the type-1 cadherin superfamily is an invasion/tumor suppressor gene, which plays a vital role in epithelial cell-cell adhesion. Epithelial E-cadherin expression loss increases tumor invasiveness and metastasis. Aim: To determine the expression of E-cadherin in oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). Materials and Methods: Analysis of E-cadherin expression in 10 cases of normal mucosa, 15 cases of various grades of OED, 15 cases of OSCC. Statistical Analysis: The data were calculated using Chi-square test and analysis of variance test (ANOVA). Results: An intragroup comparison of staining intensity and staining location for OED showed a highly significant difference between mild and moderate grade (P < 0.001). A significant difference of staining intensity was noted among well and moderately differentiated grades, and well and poorly differentiated grades of OSCC. A comparison of staining location among well and poorly differentiated grades of OSCC was found to be significant. Conclusion: Expression loss is observed as the severity of the lesion progresses in both OSCC and OED. The increased loss of expression in oral squamous cell carcinoma poorer the prognosis.
RESUMO
Objectives: This study examined the effects of stress distribution at three abutment-implant interfaces on various implant systems. Materials and Methods: Group I: tri-channel internal connection (Nobel Biocare), Group II: 1.5-mm deep internal hex (BioHorizons Co. Birmingham, USA), and Group III: ADIN Touareg, to create computerized models of implants and mandibular modeling software, close fit WP, ANSYS Version 14.0 for finite element analysis (FEA), Hypermesh 12 for meshing and CATIA were used. A top-notch scanner was used to scan the implant. CATIA software created computerized models using all the aforementioned data. By applying bonded state on the abutment-implant borders and four various load conditions within the implant system, finite element method modeling was carried out. The computerized model was imported into the ANSYS program. To compare the groups, a statistical analysis was conducted. Result: Through the use of three-dimensional FEA, the samples were assessed. Stress was found to be utmost in Group I, followed by Group III and Group II, at 80 N, 80 N with a 15° tilt, 250 N, and 250 N with a 15° tilt, and the divergence was statistically inconsequential. Conclusion: The tri-channel internal connection displayed the highest stresses compared to the internal hex within the constraints of the current study.
RESUMO
The present study examines covariates of food security and the impact of Covid-19 induced shocks, among households in India using a nationally representative survey. Using a 2SLS panel regression model, we find an important role of incomes, relative food prices, household characteristics, as well as mobility restrictions in response to the rising number of infections in a given region in explaining varying food expenditure shares prior to and during the Covid-19 pandemic. The disproportionate burden of the pandemic induced lockdowns on the disadvantaged and minorities calls for effective action on the part of policymakers to boost aggregate demand, fix supply chains and reduce food price volatility.
