[The use of flavonoid antioxidants in the complex treatment of patients with peripheral vitreo-chorioretinal dystrophies and dystrophic retinal detachment]. / Primenenie flavonoidnykh antioksidantov v kompleksnom lechenii bol'nykh s perifericheskimi vitreokhorioretinal'nymi distrofiiami i distroficheskoi otsloikoi setchatki.

Parameters of lipid peroxidation (LP) and antioxidant activity (AOA) of tear and blood plasma were examined in 22 healthy subjects (44 eyes) as well as in 33 patients with peripheral vitreochoreoretinal dystrophies (PVCRD--60 eyes), in 32 patients with non-operated dystrophic retinal detachment (DRD--34 eyes) and in 135 patients with operated retinal detachment, stable visual functions and with the postoperative period ranging from 4 months to 10 years (137 eyes). The results denoted a lower tear AOA (on the average by 35%) in patients with DRD and PVCRD, whereas, the blood plasma AOA or LP products' content remained unchanged. It is indicative of a local nature of metabolic impairments, specifically, of impairments in the system of antioxidant protection of the eye. Flavonoid antioxidants (dikvertin and ginkgo biloba) reduced the content of LP products, and induced the AOA in tear and blood plasma in patients with PVCRD and retinal detachment; they also improved the visual functions in patients with operated retinal detachment. Therefore, the flavonoid antioxidants can be recommended for adding to the complex treatment of PVCRD and DRD for the purpose of improving and stabilizing the visual functions and for neuroprotection.

[Peripheral vitreochorioretinal dystrophies in myopia patients]. / Perifericheskie vitreokhorioretinal'nye distrofii u bol'nykh s miopiei.

The problem of retinal detachment prevention is closely connected with a competent diagnosis of peripheral vitreochorioretinal dystrophies (PVCRD). The present research was aimed at analysis of PVCRD incidence in myopia of various degree and of the incidence of pathologic shifts requiring prophylactic laser coagulation or cryopexy. A total of 1022 patients (2044 eyes) with myopia of various degrees aged 5 to 58 were examined. Sclerocompression method was used in ophthalmoscopy in all the cases. PVCRD were diagnosed in 73.2% of patients. The detection rate of this condition was directly proportional to myopia degree; 52.6% in weak myopia, 70.7% in medium-grave myopia, 86.4% in high myopia. The detected patients with PVCRD were in need of preventive treatment whatever myopia degree: 38.7% of those with weak myopia, 46.9% of those with medium-grave myopia, and 46.5% of those with high myopia, 42.4% of patients with myopia on an average. Detachment of the retina was diagnosed in 4% of patients with myopia, in 0.5% surgical treatment of this condition was needed, and in 3.5% it was subclinical, this permitting a prophylactic laser coagulation.